BONE MARROW INVASION BY ASPERGILLUS SPECIE IN A SICKLE CELL TRAIT PATIENT WITH INVASIVE ASPERGILLOSIS: A FATAL CASE IN ASSOCIATION WITH DISSEMINATED INTRAVASCULAR COAGULATION

Background: Invasive aspergillosis has been predominantly associated with pulmonary infection, particularly amongst immunocompromised individuals. Extrapulmonary infections with Aspergillus specie have been reported rarely irrespective of immune status. Risk factors for invasive aspergillosis includ...

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Autores principales:	Farouk AG, Ibrahim BA, Umar UH, Bukar AA, Ambe JP
Formato:	article
Lenguaje:	EN
Publicado:	Ntec Specialist 2020
Materias:	bone marrow chronic invasive aspergillosis sickle cell trait Medicine (General) R5-920 Dentistry RK1-715
Acceso en línea:	https://doaj.org/article/3b658f5a85634678978213cb51daa7e7
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spelling	oai:doaj.org-article:3b658f5a85634678978213cb51daa7e72021-11-12T14:11:22ZBONE MARROW INVASION BY ASPERGILLUS SPECIE IN A SICKLE CELL TRAIT PATIENT WITH INVASIVE ASPERGILLOSIS: A FATAL CASE IN ASSOCIATION WITH DISSEMINATED INTRAVASCULAR COAGULATION2006-47722714-242610.36020/kjms.2020.1401.010https://doaj.org/article/3b658f5a85634678978213cb51daa7e72020-01-01T00:00:00Zhttps://kjmsmedicaljournal.com/wp-content/uploads/2020/07/10.-Farouk-AG-et-al-vol14no1.pdfhttps://doaj.org/toc/2006-4772https://doaj.org/toc/2714-2426Background: Invasive aspergillosis has been predominantly associated with pulmonary infection, particularly amongst immunocompromised individuals. Extrapulmonary infections with Aspergillus specie have been reported rarely irrespective of immune status. Risk factors for invasive aspergillosis include prolonged and severe neutropenia, haematopoietic stem cell and solid organ transplantation, advanced AIDS, and chronic granulomatous disease. The most frequently involved specie is Aspergillus fumigatus that constitutes over 90% of cases, followed by Aspergillus flavus, usually associated with a primary skin infection. Haematogenous spread to the bone causing osteomyelitis is the commonest form of disseminated aspergillosis and a surprisingly high proportion of these patients have no immunosuppression. We present a rare case of bone marrow invasion by Aspergillusspp. in a 3-year-old patient with sickle cell trait and chronic Aspergillosis. Case report: A 3-year-old patient with sickle cell trait was brought to the paediatric unit with recurrent diarrhoea, abdominal distention, weight loss and persistent cough. The child was severely wasted with generalised peripheral lymphadenopathy. She had marked respiratory distress and hepatosplenomegaly but no demonstrable ascites. Haematologic examination revealed leukaemoid reaction (leukocyte count of 44.0 x 109/L) with monocytosis (10%) and thrombocytopenia (platelet count of 97,000/mm3); no blast cells were seen on blood film. The bone marrow was hypercellular with a myeloid/erythroid ratio of 20:1, consistent with infection. Bone Marrow culture yielded Aspergillus spp. and other results of sepsis work up were negative. Conclusion: Cases of extrapulmonary invasive aspergillosis have been reported rarely in both immunocompetent and immunocompromised patients. Haematogenous spread to the bone is the commonest form of disseminated diseaseFarouk AGIbrahim BAUmar UHBukar AAAmbe JPNtec Specialistarticlebone marrowchronicinvasive aspergillosissickle cell traitMedicine (General)R5-920DentistryRK1-715ENKanem Journal of Medical Sciences, Vol 14, Iss 1, Pp 72-77 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	bone marrow chronic invasive aspergillosis sickle cell trait Medicine (General) R5-920 Dentistry RK1-715
spellingShingle	bone marrow chronic invasive aspergillosis sickle cell trait Medicine (General) R5-920 Dentistry RK1-715 Farouk AG Ibrahim BA Umar UH Bukar AA Ambe JP BONE MARROW INVASION BY ASPERGILLUS SPECIE IN A SICKLE CELL TRAIT PATIENT WITH INVASIVE ASPERGILLOSIS: A FATAL CASE IN ASSOCIATION WITH DISSEMINATED INTRAVASCULAR COAGULATION
description	Background: Invasive aspergillosis has been predominantly associated with pulmonary infection, particularly amongst immunocompromised individuals. Extrapulmonary infections with Aspergillus specie have been reported rarely irrespective of immune status. Risk factors for invasive aspergillosis include prolonged and severe neutropenia, haematopoietic stem cell and solid organ transplantation, advanced AIDS, and chronic granulomatous disease. The most frequently involved specie is Aspergillus fumigatus that constitutes over 90% of cases, followed by Aspergillus flavus, usually associated with a primary skin infection. Haematogenous spread to the bone causing osteomyelitis is the commonest form of disseminated aspergillosis and a surprisingly high proportion of these patients have no immunosuppression. We present a rare case of bone marrow invasion by Aspergillusspp. in a 3-year-old patient with sickle cell trait and chronic Aspergillosis. Case report: A 3-year-old patient with sickle cell trait was brought to the paediatric unit with recurrent diarrhoea, abdominal distention, weight loss and persistent cough. The child was severely wasted with generalised peripheral lymphadenopathy. She had marked respiratory distress and hepatosplenomegaly but no demonstrable ascites. Haematologic examination revealed leukaemoid reaction (leukocyte count of 44.0 x 109/L) with monocytosis (10%) and thrombocytopenia (platelet count of 97,000/mm3); no blast cells were seen on blood film. The bone marrow was hypercellular with a myeloid/erythroid ratio of 20:1, consistent with infection. Bone Marrow culture yielded Aspergillus spp. and other results of sepsis work up were negative. Conclusion: Cases of extrapulmonary invasive aspergillosis have been reported rarely in both immunocompetent and immunocompromised patients. Haematogenous spread to the bone is the commonest form of disseminated disease
format	article
author	Farouk AG Ibrahim BA Umar UH Bukar AA Ambe JP
author_facet	Farouk AG Ibrahim BA Umar UH Bukar AA Ambe JP
author_sort	Farouk AG
title	BONE MARROW INVASION BY ASPERGILLUS SPECIE IN A SICKLE CELL TRAIT PATIENT WITH INVASIVE ASPERGILLOSIS: A FATAL CASE IN ASSOCIATION WITH DISSEMINATED INTRAVASCULAR COAGULATION
title_short	BONE MARROW INVASION BY ASPERGILLUS SPECIE IN A SICKLE CELL TRAIT PATIENT WITH INVASIVE ASPERGILLOSIS: A FATAL CASE IN ASSOCIATION WITH DISSEMINATED INTRAVASCULAR COAGULATION
title_full	BONE MARROW INVASION BY ASPERGILLUS SPECIE IN A SICKLE CELL TRAIT PATIENT WITH INVASIVE ASPERGILLOSIS: A FATAL CASE IN ASSOCIATION WITH DISSEMINATED INTRAVASCULAR COAGULATION
title_fullStr	BONE MARROW INVASION BY ASPERGILLUS SPECIE IN A SICKLE CELL TRAIT PATIENT WITH INVASIVE ASPERGILLOSIS: A FATAL CASE IN ASSOCIATION WITH DISSEMINATED INTRAVASCULAR COAGULATION
title_full_unstemmed	BONE MARROW INVASION BY ASPERGILLUS SPECIE IN A SICKLE CELL TRAIT PATIENT WITH INVASIVE ASPERGILLOSIS: A FATAL CASE IN ASSOCIATION WITH DISSEMINATED INTRAVASCULAR COAGULATION
title_sort	bone marrow invasion by aspergillus specie in a sickle cell trait patient with invasive aspergillosis: a fatal case in association with disseminated intravascular coagulation
publisher	Ntec Specialist
publishDate	2020
url	https://doaj.org/article/3b658f5a85634678978213cb51daa7e7
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BONE MARROW INVASION BY ASPERGILLUS SPECIE IN A SICKLE CELL TRAIT PATIENT WITH INVASIVE ASPERGILLOSIS: A FATAL CASE IN ASSOCIATION WITH DISSEMINATED INTRAVASCULAR COAGULATION

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