Reprogramming of microRNA expression via E2F1 downregulation promotes Salmonella infection both in infected and bystander cells

Cells infected with pathogens can release signals that instruct neighbouring cells to mount an immune response or that reduce these cells’ susceptibility to infection. Here, Aguilar et al. show the opposite effect: cells infected with Salmonella Typhimurium secrete host factors that facilitate the i...

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Autores principales:	Carmen Aguilar, Susana Costa, Claire Maudet, R. P. Vivek-Ananth, Sara Zaldívar-López, Juan J. Garrido, Areejit Samal, Miguel Mano, Ana Eulalio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3b6c5dc6f71647b7a9b6dbcf1c2b558f
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spelling	oai:doaj.org-article:3b6c5dc6f71647b7a9b6dbcf1c2b558f2021-12-02T17:47:02ZReprogramming of microRNA expression via E2F1 downregulation promotes Salmonella infection both in infected and bystander cells10.1038/s41467-021-23593-z2041-1723https://doaj.org/article/3b6c5dc6f71647b7a9b6dbcf1c2b558f2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23593-zhttps://doaj.org/toc/2041-1723Cells infected with pathogens can release signals that instruct neighbouring cells to mount an immune response or that reduce these cells’ susceptibility to infection. Here, Aguilar et al. show the opposite effect: cells infected with Salmonella Typhimurium secrete host factors that facilitate the infection of bystander cells by activating their ER-stress response.Carmen AguilarSusana CostaClaire MaudetR. P. Vivek-AnanthSara Zaldívar-LópezJuan J. GarridoAreejit SamalMiguel ManoAna EulalioNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Carmen Aguilar Susana Costa Claire Maudet R. P. Vivek-Ananth Sara Zaldívar-López Juan J. Garrido Areejit Samal Miguel Mano Ana Eulalio Reprogramming of microRNA expression via E2F1 downregulation promotes Salmonella infection both in infected and bystander cells
description	Cells infected with pathogens can release signals that instruct neighbouring cells to mount an immune response or that reduce these cells’ susceptibility to infection. Here, Aguilar et al. show the opposite effect: cells infected with Salmonella Typhimurium secrete host factors that facilitate the infection of bystander cells by activating their ER-stress response.
format	article
author	Carmen Aguilar Susana Costa Claire Maudet R. P. Vivek-Ananth Sara Zaldívar-López Juan J. Garrido Areejit Samal Miguel Mano Ana Eulalio
author_facet	Carmen Aguilar Susana Costa Claire Maudet R. P. Vivek-Ananth Sara Zaldívar-López Juan J. Garrido Areejit Samal Miguel Mano Ana Eulalio
author_sort	Carmen Aguilar
title	Reprogramming of microRNA expression via E2F1 downregulation promotes Salmonella infection both in infected and bystander cells
title_short	Reprogramming of microRNA expression via E2F1 downregulation promotes Salmonella infection both in infected and bystander cells
title_full	Reprogramming of microRNA expression via E2F1 downregulation promotes Salmonella infection both in infected and bystander cells
title_fullStr	Reprogramming of microRNA expression via E2F1 downregulation promotes Salmonella infection both in infected and bystander cells
title_full_unstemmed	Reprogramming of microRNA expression via E2F1 downregulation promotes Salmonella infection both in infected and bystander cells
title_sort	reprogramming of microrna expression via e2f1 downregulation promotes salmonella infection both in infected and bystander cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3b6c5dc6f71647b7a9b6dbcf1c2b558f
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Reprogramming of microRNA expression via E2F1 downregulation promotes Salmonella infection both in infected and bystander cells

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