Comparison of graphical optimization or IPSA for improving brachytheraphy plans associated with inadequate target coverage for cervical cancer

Abstract Many studies have reported that inverse planning by simulated annealing (IPSA) can improve the quality of brachytherapy plans, and we wanted to examine whether IPSA could improve cervical cancer brachytherapy plans giving D90 < 6 Gy (with 7 Gy per fraction) at our institution. Various IP...

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Autores principales:	ZhiJie Liu, HuanQing Liang, Xiao Wang, HaiMing Yang, Ye Deng, TingJun Luo, ChaoFeng Yang, Min Lu, QingGuo Fu, XiaoDong Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3b6f01bd354142b9ab911345d16b0446
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spelling	oai:doaj.org-article:3b6f01bd354142b9ab911345d16b04462021-12-02T15:05:39ZComparison of graphical optimization or IPSA for improving brachytheraphy plans associated with inadequate target coverage for cervical cancer10.1038/s41598-017-16756-w2045-2322https://doaj.org/article/3b6f01bd354142b9ab911345d16b04462017-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-16756-whttps://doaj.org/toc/2045-2322Abstract Many studies have reported that inverse planning by simulated annealing (IPSA) can improve the quality of brachytherapy plans, and we wanted to examine whether IPSA could improve cervical cancer brachytherapy plans giving D90 < 6 Gy (with 7 Gy per fraction) at our institution. Various IPSA plans involving the tandem and ovoid applicators were developed for 30 consecutive cervical cancer patients on the basis of computed tomography: IPSA1, with a constraint on the maximum dose in the target volume; IPSA1-0, identical to IPSA1 but without a dwell-time deviation constraint; IPSA2, without a constraint on the maximum dose; and IPSA2-0, identical to IPSA2 but without a dwell-time deviation constraint. IPSA2 achieved similar results as graphical optimization, and none of the other IPSA plans was significantly better than graphical optimization. Therefore, other approaches, such as combining interstitial and intracavitary brachytherapy, may be more appropriate for improving the quality of brachytherapy plans associated with inadequate target coverage.ZhiJie LiuHuanQing LiangXiao WangHaiMing YangYe DengTingJun LuoChaoFeng YangMin LuQingGuo FuXiaoDong ZhuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q ZhiJie Liu HuanQing Liang Xiao Wang HaiMing Yang Ye Deng TingJun Luo ChaoFeng Yang Min Lu QingGuo Fu XiaoDong Zhu Comparison of graphical optimization or IPSA for improving brachytheraphy plans associated with inadequate target coverage for cervical cancer
description	Abstract Many studies have reported that inverse planning by simulated annealing (IPSA) can improve the quality of brachytherapy plans, and we wanted to examine whether IPSA could improve cervical cancer brachytherapy plans giving D90 < 6 Gy (with 7 Gy per fraction) at our institution. Various IPSA plans involving the tandem and ovoid applicators were developed for 30 consecutive cervical cancer patients on the basis of computed tomography: IPSA1, with a constraint on the maximum dose in the target volume; IPSA1-0, identical to IPSA1 but without a dwell-time deviation constraint; IPSA2, without a constraint on the maximum dose; and IPSA2-0, identical to IPSA2 but without a dwell-time deviation constraint. IPSA2 achieved similar results as graphical optimization, and none of the other IPSA plans was significantly better than graphical optimization. Therefore, other approaches, such as combining interstitial and intracavitary brachytherapy, may be more appropriate for improving the quality of brachytherapy plans associated with inadequate target coverage.
format	article
author	ZhiJie Liu HuanQing Liang Xiao Wang HaiMing Yang Ye Deng TingJun Luo ChaoFeng Yang Min Lu QingGuo Fu XiaoDong Zhu
author_facet	ZhiJie Liu HuanQing Liang Xiao Wang HaiMing Yang Ye Deng TingJun Luo ChaoFeng Yang Min Lu QingGuo Fu XiaoDong Zhu
author_sort	ZhiJie Liu
title	Comparison of graphical optimization or IPSA for improving brachytheraphy plans associated with inadequate target coverage for cervical cancer
title_short	Comparison of graphical optimization or IPSA for improving brachytheraphy plans associated with inadequate target coverage for cervical cancer
title_full	Comparison of graphical optimization or IPSA for improving brachytheraphy plans associated with inadequate target coverage for cervical cancer
title_fullStr	Comparison of graphical optimization or IPSA for improving brachytheraphy plans associated with inadequate target coverage for cervical cancer
title_full_unstemmed	Comparison of graphical optimization or IPSA for improving brachytheraphy plans associated with inadequate target coverage for cervical cancer
title_sort	comparison of graphical optimization or ipsa for improving brachytheraphy plans associated with inadequate target coverage for cervical cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3b6f01bd354142b9ab911345d16b0446
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Comparison of graphical optimization or IPSA for improving brachytheraphy plans associated with inadequate target coverage for cervical cancer

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