Pseudomonas aeruginosa PcrV Enhances the Nitric Oxide-Mediated Tumoricidal Activity of Tumor-Associated Macrophages via a TLR4/PI3K/AKT/mTOR-Glycolysis-Nitric Oxide Circuit
Tumor-associated macrophages (TAMs), which display a tumor-supportive M2 phenotype, are closely related to tumor growth and metastasis. The reprogramming of TAMs toward a tumoricidal M1 profile has emerged as an attractive strategy for cancer immunotherapy. In this study, we found that the intratumo...
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Autores principales: | Hua Yu, Ying Bai, Jing Qiu, Xiaomei He, Junzhi Xiong, Qian Dai, Xingmin Wang, Yuanyuan Li, Halei Sheng, Rong Xin, Lu Jiang, Qiaoqiao Li, Defeng Li, Hong Zhang, Le Zhang, Qian Chen, Jin Peng, Xiaomei Hu, Kebin Zhang |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/3b6f24f61d9f48d5acc98567f852e72c |
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