Effect of hydroalcoholic extracts of flower and fruit peel of Punica granatum on Leishmania major promastigotes in vitro

Background and aims: Cutaneous leishmaniasis is one of the endemic parasitic diseases in many regions of Iran for which there is currently no complete vaccine and effective drugs without drug resistance to prevent and treat it. Given the need to develop new drugs for the treatment of various disease...

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Autores principales:	Hamidreza Mardani, Bahman Khalili, Sedigheh Saberi, Zahra Lorigooini, Milad Ghaderi, Rahman Abdizadeh
Formato:	article
Lenguaje:	EN
Publicado:	Shahrekord University of Medical Sciences 2020
Materias:	punica granatum fruit peel punica granatum flower leishmania major antiparasitic activity in vitro techniques Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3b717fb9158f4562a9ea1c35424bed07
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spelling	oai:doaj.org-article:3b717fb9158f4562a9ea1c35424bed072021-11-13T05:12:32ZEffect of hydroalcoholic extracts of flower and fruit peel of Punica granatum on Leishmania major promastigotes in vitro2423-3579https://doaj.org/article/3b717fb9158f4562a9ea1c35424bed072020-07-01T00:00:00Zhttp://herbmed.skums.ac.ir/article_246252_1d475815bf90364e7ee17d306986b89e.pdfhttps://doaj.org/toc/2423-3579Background and aims: Cutaneous leishmaniasis is one of the endemic parasitic diseases in many regions of Iran for which there is currently no complete vaccine and effective drugs without drug resistance to prevent and treat it. Given the need to develop new drugs for the treatment of various diseases with fewer side effects, greater effects with shorter treatment periods, especially in anti-leishmaniasis drug compounds for drug-resistant types of the disease, it is essential to do research on plant compounds containing medicinal compounds to promote the treatment of this infection. The present study was performed to compare the in vitro effects of hydroalcoholic extracts of flower and fruit peel of Punica granatum on Leishmania major promastigotes.Methods: Different dilutions of hydroalcoholic extracts of flower and fruit peel of P. granatum were prepared by the maceration method and their in vitro effects on L. major promastigote were investigated using MTT assay. Data were analyzed using SPSS software version 22.Results: The results showed that both hydroalcoholic extracts of flower and fruit peel of P. granatum could inhibit the parasite, but the extract fruit peel of P. granatum showed anti-leishmaniasis activity at lower concentrations compared to extract flower of P. granatum.Conclusion: The hydroalcoholic extracts of flower and fruit peel of P. granatum could inhibit the parasite, that probably due to the presence of some compounds such as ellagic acid with antioxidant properties and punicalagin with antimicrobial properties especially in fruit peel extract of P. granatum.Hamidreza MardaniBahman KhaliliSedigheh SaberiZahra LorigooiniMilad GhaderiRahman AbdizadehShahrekord University of Medical Sciencesarticlepunica granatum fruit peelpunica granatum flowerleishmania majorantiparasitic activityin vitro techniquesMedicineRScienceQENAdvanced Herbal Medicine , Vol 6, Iss 2, Pp 32-48 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	punica granatum fruit peel punica granatum flower leishmania major antiparasitic activity in vitro techniques Medicine R Science Q
spellingShingle	punica granatum fruit peel punica granatum flower leishmania major antiparasitic activity in vitro techniques Medicine R Science Q Hamidreza Mardani Bahman Khalili Sedigheh Saberi Zahra Lorigooini Milad Ghaderi Rahman Abdizadeh Effect of hydroalcoholic extracts of flower and fruit peel of Punica granatum on Leishmania major promastigotes in vitro
description	Background and aims: Cutaneous leishmaniasis is one of the endemic parasitic diseases in many regions of Iran for which there is currently no complete vaccine and effective drugs without drug resistance to prevent and treat it. Given the need to develop new drugs for the treatment of various diseases with fewer side effects, greater effects with shorter treatment periods, especially in anti-leishmaniasis drug compounds for drug-resistant types of the disease, it is essential to do research on plant compounds containing medicinal compounds to promote the treatment of this infection. The present study was performed to compare the in vitro effects of hydroalcoholic extracts of flower and fruit peel of Punica granatum on Leishmania major promastigotes.Methods: Different dilutions of hydroalcoholic extracts of flower and fruit peel of P. granatum were prepared by the maceration method and their in vitro effects on L. major promastigote were investigated using MTT assay. Data were analyzed using SPSS software version 22.Results: The results showed that both hydroalcoholic extracts of flower and fruit peel of P. granatum could inhibit the parasite, but the extract fruit peel of P. granatum showed anti-leishmaniasis activity at lower concentrations compared to extract flower of P. granatum.Conclusion: The hydroalcoholic extracts of flower and fruit peel of P. granatum could inhibit the parasite, that probably due to the presence of some compounds such as ellagic acid with antioxidant properties and punicalagin with antimicrobial properties especially in fruit peel extract of P. granatum.
format	article
author	Hamidreza Mardani Bahman Khalili Sedigheh Saberi Zahra Lorigooini Milad Ghaderi Rahman Abdizadeh
author_facet	Hamidreza Mardani Bahman Khalili Sedigheh Saberi Zahra Lorigooini Milad Ghaderi Rahman Abdizadeh
author_sort	Hamidreza Mardani
title	Effect of hydroalcoholic extracts of flower and fruit peel of Punica granatum on Leishmania major promastigotes in vitro
title_short	Effect of hydroalcoholic extracts of flower and fruit peel of Punica granatum on Leishmania major promastigotes in vitro
title_full	Effect of hydroalcoholic extracts of flower and fruit peel of Punica granatum on Leishmania major promastigotes in vitro
title_fullStr	Effect of hydroalcoholic extracts of flower and fruit peel of Punica granatum on Leishmania major promastigotes in vitro
title_full_unstemmed	Effect of hydroalcoholic extracts of flower and fruit peel of Punica granatum on Leishmania major promastigotes in vitro
title_sort	effect of hydroalcoholic extracts of flower and fruit peel of punica granatum on leishmania major promastigotes in vitro
publisher	Shahrekord University of Medical Sciences
publishDate	2020
url	https://doaj.org/article/3b717fb9158f4562a9ea1c35424bed07
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Effect of hydroalcoholic extracts of flower and fruit peel of Punica granatum on Leishmania major promastigotes in vitro

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