Gene regulation contributes to explain the impact of early life socioeconomic disadvantage on adult inflammatory levels in two cohort studies

Abstract Individuals experiencing socioeconomic disadvantage in childhood have a higher rate of inflammation-related diseases decades later. Little is known about the mechanisms linking early life experiences to the functioning of the immune system in adulthood. To address this, we explore the relat...

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Autores principales:	Cristian Carmeli, Zoltán Kutalik, Pashupati P. Mishra, Eleonora Porcu, Cyrille Delpierre, Olivier Delaneau, Michelle Kelly-Irving, Murielle Bochud, Nasser A. Dhayat, Belen Ponte, Menno Pruijm, Georg Ehret, Mika Kähönen, Terho Lehtimäki, Olli T. Raitakari, Paolo Vineis, Mika Kivimäki, Marc Chadeau-Hyam, Emmanouil Dermitzakis, Nicolas Vuilleumier, Silvia Stringhini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3b7d5e43ca5647d5bb4f761bb458c0cd
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spelling	oai:doaj.org-article:3b7d5e43ca5647d5bb4f761bb458c0cd2021-12-02T14:06:18ZGene regulation contributes to explain the impact of early life socioeconomic disadvantage on adult inflammatory levels in two cohort studies10.1038/s41598-021-82714-22045-2322https://doaj.org/article/3b7d5e43ca5647d5bb4f761bb458c0cd2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82714-2https://doaj.org/toc/2045-2322Abstract Individuals experiencing socioeconomic disadvantage in childhood have a higher rate of inflammation-related diseases decades later. Little is known about the mechanisms linking early life experiences to the functioning of the immune system in adulthood. To address this, we explore the relationship across social-to-biological layers of early life social exposures on levels of adulthood inflammation and the mediating role of gene regulatory mechanisms, epigenetic and transcriptomic profiling from blood, in 2,329 individuals from two European cohort studies. Consistently across both studies, we find transcriptional activity explains a substantive proportion (78% and 26%) of the estimated effect of early life disadvantaged social exposures on levels of adulthood inflammation. Furthermore, we show that mechanisms other than cis DNA methylation may regulate those transcriptional fingerprints. These results further our understanding of social-to-biological transitions by pinpointing the role of gene regulation that cannot fully be explained by differential cis DNA methylation.Cristian CarmeliZoltán KutalikPashupati P. MishraEleonora PorcuCyrille DelpierreOlivier DelaneauMichelle Kelly-IrvingMurielle BochudNasser A. DhayatBelen PonteMenno PruijmGeorg EhretMika KähönenTerho LehtimäkiOlli T. RaitakariPaolo VineisMika KivimäkiMarc Chadeau-HyamEmmanouil DermitzakisNicolas VuilleumierSilvia StringhiniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cristian Carmeli Zoltán Kutalik Pashupati P. Mishra Eleonora Porcu Cyrille Delpierre Olivier Delaneau Michelle Kelly-Irving Murielle Bochud Nasser A. Dhayat Belen Ponte Menno Pruijm Georg Ehret Mika Kähönen Terho Lehtimäki Olli T. Raitakari Paolo Vineis Mika Kivimäki Marc Chadeau-Hyam Emmanouil Dermitzakis Nicolas Vuilleumier Silvia Stringhini Gene regulation contributes to explain the impact of early life socioeconomic disadvantage on adult inflammatory levels in two cohort studies
description	Abstract Individuals experiencing socioeconomic disadvantage in childhood have a higher rate of inflammation-related diseases decades later. Little is known about the mechanisms linking early life experiences to the functioning of the immune system in adulthood. To address this, we explore the relationship across social-to-biological layers of early life social exposures on levels of adulthood inflammation and the mediating role of gene regulatory mechanisms, epigenetic and transcriptomic profiling from blood, in 2,329 individuals from two European cohort studies. Consistently across both studies, we find transcriptional activity explains a substantive proportion (78% and 26%) of the estimated effect of early life disadvantaged social exposures on levels of adulthood inflammation. Furthermore, we show that mechanisms other than cis DNA methylation may regulate those transcriptional fingerprints. These results further our understanding of social-to-biological transitions by pinpointing the role of gene regulation that cannot fully be explained by differential cis DNA methylation.
format	article
author	Cristian Carmeli Zoltán Kutalik Pashupati P. Mishra Eleonora Porcu Cyrille Delpierre Olivier Delaneau Michelle Kelly-Irving Murielle Bochud Nasser A. Dhayat Belen Ponte Menno Pruijm Georg Ehret Mika Kähönen Terho Lehtimäki Olli T. Raitakari Paolo Vineis Mika Kivimäki Marc Chadeau-Hyam Emmanouil Dermitzakis Nicolas Vuilleumier Silvia Stringhini
author_facet	Cristian Carmeli Zoltán Kutalik Pashupati P. Mishra Eleonora Porcu Cyrille Delpierre Olivier Delaneau Michelle Kelly-Irving Murielle Bochud Nasser A. Dhayat Belen Ponte Menno Pruijm Georg Ehret Mika Kähönen Terho Lehtimäki Olli T. Raitakari Paolo Vineis Mika Kivimäki Marc Chadeau-Hyam Emmanouil Dermitzakis Nicolas Vuilleumier Silvia Stringhini
author_sort	Cristian Carmeli
title	Gene regulation contributes to explain the impact of early life socioeconomic disadvantage on adult inflammatory levels in two cohort studies
title_short	Gene regulation contributes to explain the impact of early life socioeconomic disadvantage on adult inflammatory levels in two cohort studies
title_full	Gene regulation contributes to explain the impact of early life socioeconomic disadvantage on adult inflammatory levels in two cohort studies
title_fullStr	Gene regulation contributes to explain the impact of early life socioeconomic disadvantage on adult inflammatory levels in two cohort studies
title_full_unstemmed	Gene regulation contributes to explain the impact of early life socioeconomic disadvantage on adult inflammatory levels in two cohort studies
title_sort	gene regulation contributes to explain the impact of early life socioeconomic disadvantage on adult inflammatory levels in two cohort studies
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3b7d5e43ca5647d5bb4f761bb458c0cd
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Gene regulation contributes to explain the impact of early life socioeconomic disadvantage on adult inflammatory levels in two cohort studies

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