NFATc1 controls the cytotoxicity of CD8+ T cells

NFAT nuclear translocation has been shown to be required for CD8+ T cell cytokine production in response to viral infection. Here the authors show NFATc1 controls the cytotoxicity and metabolic switching of activated CD8+ T cells required for optimal response to bacteria and tumor cells.

Guardado en:

Detalles Bibliográficos
Autores principales:	Stefan Klein-Hessling, Khalid Muhammad, Matthias Klein, Tobias Pusch, Ronald Rudolf, Jessica Flöter, Musga Qureischi, Andreas Beilhack, Martin Vaeth, Carsten Kummerow, Christian Backes, Rouven Schoppmeyer, Ulrike Hahn, Markus Hoth, Tobias Bopp, Friederike Berberich-Siebelt, Amiya Patra, Andris Avots, Nora Müller, Almut Schulze, Edgar Serfling
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3b7e704afb8e41c391e25990abf690c1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3b7e704afb8e41c391e25990abf690c1
record_format	dspace
spelling	oai:doaj.org-article:3b7e704afb8e41c391e25990abf690c12021-12-02T14:40:58ZNFATc1 controls the cytotoxicity of CD8+ T cells10.1038/s41467-017-00612-62041-1723https://doaj.org/article/3b7e704afb8e41c391e25990abf690c12017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00612-6https://doaj.org/toc/2041-1723NFAT nuclear translocation has been shown to be required for CD8+ T cell cytokine production in response to viral infection. Here the authors show NFATc1 controls the cytotoxicity and metabolic switching of activated CD8+ T cells required for optimal response to bacteria and tumor cells.Stefan Klein-HesslingKhalid MuhammadMatthias KleinTobias PuschRonald RudolfJessica FlöterMusga QureischiAndreas BeilhackMartin VaethCarsten KummerowChristian BackesRouven SchoppmeyerUlrike HahnMarkus HothTobias BoppFriederike Berberich-SiebeltAmiya PatraAndris AvotsNora MüllerAlmut SchulzeEdgar SerflingNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stefan Klein-Hessling Khalid Muhammad Matthias Klein Tobias Pusch Ronald Rudolf Jessica Flöter Musga Qureischi Andreas Beilhack Martin Vaeth Carsten Kummerow Christian Backes Rouven Schoppmeyer Ulrike Hahn Markus Hoth Tobias Bopp Friederike Berberich-Siebelt Amiya Patra Andris Avots Nora Müller Almut Schulze Edgar Serfling NFATc1 controls the cytotoxicity of CD8+ T cells
description	NFAT nuclear translocation has been shown to be required for CD8+ T cell cytokine production in response to viral infection. Here the authors show NFATc1 controls the cytotoxicity and metabolic switching of activated CD8+ T cells required for optimal response to bacteria and tumor cells.
format	article
author	Stefan Klein-Hessling Khalid Muhammad Matthias Klein Tobias Pusch Ronald Rudolf Jessica Flöter Musga Qureischi Andreas Beilhack Martin Vaeth Carsten Kummerow Christian Backes Rouven Schoppmeyer Ulrike Hahn Markus Hoth Tobias Bopp Friederike Berberich-Siebelt Amiya Patra Andris Avots Nora Müller Almut Schulze Edgar Serfling
author_facet	Stefan Klein-Hessling Khalid Muhammad Matthias Klein Tobias Pusch Ronald Rudolf Jessica Flöter Musga Qureischi Andreas Beilhack Martin Vaeth Carsten Kummerow Christian Backes Rouven Schoppmeyer Ulrike Hahn Markus Hoth Tobias Bopp Friederike Berberich-Siebelt Amiya Patra Andris Avots Nora Müller Almut Schulze Edgar Serfling
author_sort	Stefan Klein-Hessling
title	NFATc1 controls the cytotoxicity of CD8+ T cells
title_short	NFATc1 controls the cytotoxicity of CD8+ T cells
title_full	NFATc1 controls the cytotoxicity of CD8+ T cells
title_fullStr	NFATc1 controls the cytotoxicity of CD8+ T cells
title_full_unstemmed	NFATc1 controls the cytotoxicity of CD8+ T cells
title_sort	nfatc1 controls the cytotoxicity of cd8+ t cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3b7e704afb8e41c391e25990abf690c1
work_keys_str_mv	AT stefankleinhessling nfatc1controlsthecytotoxicityofcd8tcells AT khalidmuhammad nfatc1controlsthecytotoxicityofcd8tcells AT matthiasklein nfatc1controlsthecytotoxicityofcd8tcells AT tobiaspusch nfatc1controlsthecytotoxicityofcd8tcells AT ronaldrudolf nfatc1controlsthecytotoxicityofcd8tcells AT jessicafloter nfatc1controlsthecytotoxicityofcd8tcells AT musgaqureischi nfatc1controlsthecytotoxicityofcd8tcells AT andreasbeilhack nfatc1controlsthecytotoxicityofcd8tcells AT martinvaeth nfatc1controlsthecytotoxicityofcd8tcells AT carstenkummerow nfatc1controlsthecytotoxicityofcd8tcells AT christianbackes nfatc1controlsthecytotoxicityofcd8tcells AT rouvenschoppmeyer nfatc1controlsthecytotoxicityofcd8tcells AT ulrikehahn nfatc1controlsthecytotoxicityofcd8tcells AT markushoth nfatc1controlsthecytotoxicityofcd8tcells AT tobiasbopp nfatc1controlsthecytotoxicityofcd8tcells AT friederikeberberichsiebelt nfatc1controlsthecytotoxicityofcd8tcells AT amiyapatra nfatc1controlsthecytotoxicityofcd8tcells AT andrisavots nfatc1controlsthecytotoxicityofcd8tcells AT noramuller nfatc1controlsthecytotoxicityofcd8tcells AT almutschulze nfatc1controlsthecytotoxicityofcd8tcells AT edgarserfling nfatc1controlsthecytotoxicityofcd8tcells
_version_	1718390046336221184

NFATc1 controls the cytotoxicity of CD8+ T cells

Ejemplares similares