Pseudoknot length modulates the folding, conformational dynamics, and robustness of Xrn1 resistance of flaviviral xrRNAs

Exoribonuclease-resistant RNAs (xrRNAs) are RNA elements that block the exoribonucleolytic degradation of RNA. Here the authors show how a long-range pseudoknot length modulates the Mg2+-dependence of flaviviral xrRNA’s folding, conformational dynamics and Xrn1 resistance.

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Autores principales:	Xiaolin Niu, Ruirui Sun, Zhifeng Chen, Yirong Yao, Xiaobing Zuo, Chunlai Chen, Xianyang Fang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3b81654980444e4c84dfee67e84640e0
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spelling	oai:doaj.org-article:3b81654980444e4c84dfee67e84640e02021-11-08T11:12:37ZPseudoknot length modulates the folding, conformational dynamics, and robustness of Xrn1 resistance of flaviviral xrRNAs10.1038/s41467-021-26616-x2041-1723https://doaj.org/article/3b81654980444e4c84dfee67e84640e02021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26616-xhttps://doaj.org/toc/2041-1723Exoribonuclease-resistant RNAs (xrRNAs) are RNA elements that block the exoribonucleolytic degradation of RNA. Here the authors show how a long-range pseudoknot length modulates the Mg2+-dependence of flaviviral xrRNA’s folding, conformational dynamics and Xrn1 resistance.Xiaolin NiuRuirui SunZhifeng ChenYirong YaoXiaobing ZuoChunlai ChenXianyang FangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaolin Niu Ruirui Sun Zhifeng Chen Yirong Yao Xiaobing Zuo Chunlai Chen Xianyang Fang Pseudoknot length modulates the folding, conformational dynamics, and robustness of Xrn1 resistance of flaviviral xrRNAs
description	Exoribonuclease-resistant RNAs (xrRNAs) are RNA elements that block the exoribonucleolytic degradation of RNA. Here the authors show how a long-range pseudoknot length modulates the Mg2+-dependence of flaviviral xrRNA’s folding, conformational dynamics and Xrn1 resistance.
format	article
author	Xiaolin Niu Ruirui Sun Zhifeng Chen Yirong Yao Xiaobing Zuo Chunlai Chen Xianyang Fang
author_facet	Xiaolin Niu Ruirui Sun Zhifeng Chen Yirong Yao Xiaobing Zuo Chunlai Chen Xianyang Fang
author_sort	Xiaolin Niu
title	Pseudoknot length modulates the folding, conformational dynamics, and robustness of Xrn1 resistance of flaviviral xrRNAs
title_short	Pseudoknot length modulates the folding, conformational dynamics, and robustness of Xrn1 resistance of flaviviral xrRNAs
title_full	Pseudoknot length modulates the folding, conformational dynamics, and robustness of Xrn1 resistance of flaviviral xrRNAs
title_fullStr	Pseudoknot length modulates the folding, conformational dynamics, and robustness of Xrn1 resistance of flaviviral xrRNAs
title_full_unstemmed	Pseudoknot length modulates the folding, conformational dynamics, and robustness of Xrn1 resistance of flaviviral xrRNAs
title_sort	pseudoknot length modulates the folding, conformational dynamics, and robustness of xrn1 resistance of flaviviral xrrnas
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3b81654980444e4c84dfee67e84640e0
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Pseudoknot length modulates the folding, conformational dynamics, and robustness of Xrn1 resistance of flaviviral xrRNAs

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