Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data

Estimating direct and indirect effects of genotypes on phenotypes is important for genetic analyses such as Mendelian randomization. Here the authors compare five different methods to estimate direct and indirect genetic effects using summary results statistics that account for sample overlap.

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Autores principales:	Nicole M. Warrington, Liang-Dar Hwang, Michel G. Nivard, David M. Evans
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3b86a242695944458fd715e56be7d963
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spelling	oai:doaj.org-article:3b86a242695944458fd715e56be7d9632021-12-02T15:15:45ZEstimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data10.1038/s41467-021-25723-z2041-1723https://doaj.org/article/3b86a242695944458fd715e56be7d9632021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25723-zhttps://doaj.org/toc/2041-1723Estimating direct and indirect effects of genotypes on phenotypes is important for genetic analyses such as Mendelian randomization. Here the authors compare five different methods to estimate direct and indirect genetic effects using summary results statistics that account for sample overlap.Nicole M. WarringtonLiang-Dar HwangMichel G. NivardDavid M. EvansNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicole M. Warrington Liang-Dar Hwang Michel G. Nivard David M. Evans Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data
description	Estimating direct and indirect effects of genotypes on phenotypes is important for genetic analyses such as Mendelian randomization. Here the authors compare five different methods to estimate direct and indirect genetic effects using summary results statistics that account for sample overlap.
format	article
author	Nicole M. Warrington Liang-Dar Hwang Michel G. Nivard David M. Evans
author_facet	Nicole M. Warrington Liang-Dar Hwang Michel G. Nivard David M. Evans
author_sort	Nicole M. Warrington
title	Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data
title_short	Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data
title_full	Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data
title_fullStr	Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data
title_full_unstemmed	Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data
title_sort	estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3b86a242695944458fd715e56be7d963
work_keys_str_mv	AT nicolemwarrington estimatingdirectandindirectgeneticeffectsonoffspringphenotypesusinggenomewidesummaryresultsdata AT liangdarhwang estimatingdirectandindirectgeneticeffectsonoffspringphenotypesusinggenomewidesummaryresultsdata AT michelgnivard estimatingdirectandindirectgeneticeffectsonoffspringphenotypesusinggenomewidesummaryresultsdata AT davidmevans estimatingdirectandindirectgeneticeffectsonoffspringphenotypesusinggenomewidesummaryresultsdata
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Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data

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