EGFR-dependent TOR-independent endocycles support Drosophila gut epithelial regeneration

EGFR-dependent TOR-independent endocycles support Drosophila gut epithelial regeneration

In response to gut epithelial damage,Drosophilastem cells proliferate to produce large polyploid enterocytes (EC), which comprise the bulk of the epithelium. Here, the authors show that stress-dependent EGFR/MAP kinase signalling drives both endoreplication and cell growth in newborn ECs.

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Autores principales: Jinyi Xiang, Jennifer Bandura, Peng Zhang, Yinhua Jin, Hanna Reuter, Bruce A. Edgar
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/3b88d74b7466476f8a193deed5045a3e
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spelling oai:doaj.org-article:3b88d74b7466476f8a193deed5045a3e2021-12-02T14:42:36ZEGFR-dependent TOR-independent endocycles support Drosophila gut epithelial regeneration10.1038/ncomms151252041-1723https://doaj.org/article/3b88d74b7466476f8a193deed5045a3e2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15125https://doaj.org/toc/2041-1723In response to gut epithelial damage,Drosophilastem cells proliferate to produce large polyploid enterocytes (EC), which comprise the bulk of the epithelium. Here, the authors show that stress-dependent EGFR/MAP kinase signalling drives both endoreplication and cell growth in newborn ECs.Jinyi XiangJennifer BanduraPeng ZhangYinhua JinHanna ReuterBruce A. EdgarNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jinyi Xiang
Jennifer Bandura
Peng Zhang
Yinhua Jin
Hanna Reuter
Bruce A. Edgar
EGFR-dependent TOR-independent endocycles support Drosophila gut epithelial regeneration
description In response to gut epithelial damage,Drosophilastem cells proliferate to produce large polyploid enterocytes (EC), which comprise the bulk of the epithelium. Here, the authors show that stress-dependent EGFR/MAP kinase signalling drives both endoreplication and cell growth in newborn ECs.
format article
author Jinyi Xiang
Jennifer Bandura
Peng Zhang
Yinhua Jin
Hanna Reuter
Bruce A. Edgar
author_facet Jinyi Xiang
Jennifer Bandura
Peng Zhang
Yinhua Jin
Hanna Reuter
Bruce A. Edgar
author_sort Jinyi Xiang
title EGFR-dependent TOR-independent endocycles support Drosophila gut epithelial regeneration
title_short EGFR-dependent TOR-independent endocycles support Drosophila gut epithelial regeneration
title_full EGFR-dependent TOR-independent endocycles support Drosophila gut epithelial regeneration
title_fullStr EGFR-dependent TOR-independent endocycles support Drosophila gut epithelial regeneration
title_full_unstemmed EGFR-dependent TOR-independent endocycles support Drosophila gut epithelial regeneration
title_sort egfr-dependent tor-independent endocycles support drosophila gut epithelial regeneration
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/3b88d74b7466476f8a193deed5045a3e
work_keys_str_mv AT jinyixiang egfrdependenttorindependentendocyclessupportdrosophilagutepithelialregeneration
AT jenniferbandura egfrdependenttorindependentendocyclessupportdrosophilagutepithelialregeneration
AT pengzhang egfrdependenttorindependentendocyclessupportdrosophilagutepithelialregeneration
AT yinhuajin egfrdependenttorindependentendocyclessupportdrosophilagutepithelialregeneration
AT hannareuter egfrdependenttorindependentendocyclessupportdrosophilagutepithelialregeneration
AT bruceaedgar egfrdependenttorindependentendocyclessupportdrosophilagutepithelialregeneration
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