Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain
Amphetamines are known to enhance extracellular dopamine levels, but the underlying mechanisms are unclear. Utilising a new pH biosensor for synaptic vesicles, the authors show that amphetamines diminish vesicle pH gradients, disrupting dopamine packaging and leading to increased neurotransmitter re...
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Nature Portfolio
2016
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oai:doaj.org-article:3b8bfbbdbb454af19a8c38df694cd7dd2021-12-02T14:39:48ZMechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain10.1038/ncomms106522041-1723https://doaj.org/article/3b8bfbbdbb454af19a8c38df694cd7dd2016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10652https://doaj.org/toc/2041-1723Amphetamines are known to enhance extracellular dopamine levels, but the underlying mechanisms are unclear. Utilising a new pH biosensor for synaptic vesicles, the authors show that amphetamines diminish vesicle pH gradients, disrupting dopamine packaging and leading to increased neurotransmitter release.Zachary FreybergMark S. SondersJenny I. AguilarTakato HiranitaCaline S. KaramJorge FloresAndrea B. PizzoYuchao ZhangZachary J. FarinoAudrey ChenCiara A. MartinTheresa A. KopajticHao FeiGang HuYi-Ying LinEugene V. MosharovBrian D. McCabeRobin FreybergKandatege WimalasenaLing-Wei HsinDalibor SamesDavid E. KrantzJonathan L. KatzDavid SulzerJonathan A. JavitchNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016) |
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DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Zachary Freyberg Mark S. Sonders Jenny I. Aguilar Takato Hiranita Caline S. Karam Jorge Flores Andrea B. Pizzo Yuchao Zhang Zachary J. Farino Audrey Chen Ciara A. Martin Theresa A. Kopajtic Hao Fei Gang Hu Yi-Ying Lin Eugene V. Mosharov Brian D. McCabe Robin Freyberg Kandatege Wimalasena Ling-Wei Hsin Dalibor Sames David E. Krantz Jonathan L. Katz David Sulzer Jonathan A. Javitch Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain |
| description |
Amphetamines are known to enhance extracellular dopamine levels, but the underlying mechanisms are unclear. Utilising a new pH biosensor for synaptic vesicles, the authors show that amphetamines diminish vesicle pH gradients, disrupting dopamine packaging and leading to increased neurotransmitter release. |
| format |
article |
| author |
Zachary Freyberg Mark S. Sonders Jenny I. Aguilar Takato Hiranita Caline S. Karam Jorge Flores Andrea B. Pizzo Yuchao Zhang Zachary J. Farino Audrey Chen Ciara A. Martin Theresa A. Kopajtic Hao Fei Gang Hu Yi-Ying Lin Eugene V. Mosharov Brian D. McCabe Robin Freyberg Kandatege Wimalasena Ling-Wei Hsin Dalibor Sames David E. Krantz Jonathan L. Katz David Sulzer Jonathan A. Javitch |
| author_facet |
Zachary Freyberg Mark S. Sonders Jenny I. Aguilar Takato Hiranita Caline S. Karam Jorge Flores Andrea B. Pizzo Yuchao Zhang Zachary J. Farino Audrey Chen Ciara A. Martin Theresa A. Kopajtic Hao Fei Gang Hu Yi-Ying Lin Eugene V. Mosharov Brian D. McCabe Robin Freyberg Kandatege Wimalasena Ling-Wei Hsin Dalibor Sames David E. Krantz Jonathan L. Katz David Sulzer Jonathan A. Javitch |
| author_sort |
Zachary Freyberg |
| title |
Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain |
| title_short |
Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain |
| title_full |
Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain |
| title_fullStr |
Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain |
| title_full_unstemmed |
Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain |
| title_sort |
mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in drosophila brain |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/3b8bfbbdbb454af19a8c38df694cd7dd |
| work_keys_str_mv |
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