Serotonin signaling modulates aging-associated metabolic network integrity in response to nutrient choice in Drosophila melanogaster
Lyu et al analysed metabolic network integrity in Drosophila melanogaster to assess the systemic effects of nutrient choice. By knocking out the serotonin receptor, 5-HT2A, they demonstrated that the effects of different macronutrients on the stability of metabolic networks is mediated through serot...
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Nature Portfolio
2021
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oai:doaj.org-article:3b8e0c67b3c546be951870d33a33d1f72021-12-02T17:40:01ZSerotonin signaling modulates aging-associated metabolic network integrity in response to nutrient choice in Drosophila melanogaster10.1038/s42003-021-02260-52399-3642https://doaj.org/article/3b8e0c67b3c546be951870d33a33d1f72021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02260-5https://doaj.org/toc/2399-3642Lyu et al analysed metabolic network integrity in Drosophila melanogaster to assess the systemic effects of nutrient choice. By knocking out the serotonin receptor, 5-HT2A, they demonstrated that the effects of different macronutrients on the stability of metabolic networks is mediated through serotonin signalling.Yang LyuDaniel E. L. PromislowScott D. PletcherNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Biology (General) QH301-705.5 |
| spellingShingle |
Biology (General) QH301-705.5 Yang Lyu Daniel E. L. Promislow Scott D. Pletcher Serotonin signaling modulates aging-associated metabolic network integrity in response to nutrient choice in Drosophila melanogaster |
| description |
Lyu et al analysed metabolic network integrity in Drosophila melanogaster to assess the systemic effects of nutrient choice. By knocking out the serotonin receptor, 5-HT2A, they demonstrated that the effects of different macronutrients on the stability of metabolic networks is mediated through serotonin signalling. |
| format |
article |
| author |
Yang Lyu Daniel E. L. Promislow Scott D. Pletcher |
| author_facet |
Yang Lyu Daniel E. L. Promislow Scott D. Pletcher |
| author_sort |
Yang Lyu |
| title |
Serotonin signaling modulates aging-associated metabolic network integrity in response to nutrient choice in Drosophila melanogaster |
| title_short |
Serotonin signaling modulates aging-associated metabolic network integrity in response to nutrient choice in Drosophila melanogaster |
| title_full |
Serotonin signaling modulates aging-associated metabolic network integrity in response to nutrient choice in Drosophila melanogaster |
| title_fullStr |
Serotonin signaling modulates aging-associated metabolic network integrity in response to nutrient choice in Drosophila melanogaster |
| title_full_unstemmed |
Serotonin signaling modulates aging-associated metabolic network integrity in response to nutrient choice in Drosophila melanogaster |
| title_sort |
serotonin signaling modulates aging-associated metabolic network integrity in response to nutrient choice in drosophila melanogaster |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/3b8e0c67b3c546be951870d33a33d1f7 |
| work_keys_str_mv |
AT yanglyu serotoninsignalingmodulatesagingassociatedmetabolicnetworkintegrityinresponsetonutrientchoiceindrosophilamelanogaster AT danielelpromislow serotoninsignalingmodulatesagingassociatedmetabolicnetworkintegrityinresponsetonutrientchoiceindrosophilamelanogaster AT scottdpletcher serotoninsignalingmodulatesagingassociatedmetabolicnetworkintegrityinresponsetonutrientchoiceindrosophilamelanogaster |
| _version_ |
1718379755831558144 |