Retrospective serological study of Rickettsia spp. and Borrelia spp. antibodies in patients with peripheral facial nerve palsy

In a retrospective study, 36 patients with peripheral facial palsy were serologically evaluated for the presence of Rickettsia spp. and Borrelia spp. antibodies. All sera underwent immunofluorescence and Western blot analysis for IgG and IgM antibodies using Rickettsia helvetica and R. felis as anti...

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Autores principales:	Katarina Wallménius, Carl Påhlson, Kenneth Nilsson
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	spotted fever rickettsia facial palsy serology western blot Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/3b8f00253bcf4d3c8f287f73fa10624b
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spelling	oai:doaj.org-article:3b8f00253bcf4d3c8f287f73fa10624b2021-11-04T15:00:43ZRetrospective serological study of Rickettsia spp. and Borrelia spp. antibodies in patients with peripheral facial nerve palsy2000-868610.1080/20008686.2021.1987058https://doaj.org/article/3b8f00253bcf4d3c8f287f73fa10624b2021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/20008686.2021.1987058https://doaj.org/toc/2000-8686In a retrospective study, 36 patients with peripheral facial palsy were serologically evaluated for the presence of Rickettsia spp. and Borrelia spp. antibodies. All sera underwent immunofluorescence and Western blot analysis for IgG and IgM antibodies using Rickettsia helvetica and R. felis as antigens. Anti-Borrelia antibodies were detected using a commercial ELISA detecting Borrelia burgdorferi, B. afzelii and B. garinii. Three patients (8.3%) were seropositive for Rickettsia spp. with IgG titres equal to 1:128, and six patients (16.7%) had IgM titres equal to or above 1:128. All samples with IgG/IgM titres equal to or above 1:128 were confirmed by Western Blot. Four patients (11.1%) had IgG antibodies against Borrelia at a titre level normally judged to be indicative of current infection. Two of these patients had significant IgG or IgM titres for both Rickettsia spp. and Borrelia spp., indicating co-infection. In conclusion, the findings indicate current rickettsial infection or early response at about the same degree as for Lyme borreliosis in patients with facial palsy, but they need to be further examined with a larger number of patients and paired serum analyses.Katarina WallméniusCarl PåhlsonKenneth NilssonTaylor & Francis Grouparticlespotted fever rickettsiafacial palsyserologywestern blotInfectious and parasitic diseasesRC109-216ENInfection Ecology & Epidemiology, Vol 11, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	spotted fever rickettsia facial palsy serology western blot Infectious and parasitic diseases RC109-216
spellingShingle	spotted fever rickettsia facial palsy serology western blot Infectious and parasitic diseases RC109-216 Katarina Wallménius Carl Påhlson Kenneth Nilsson Retrospective serological study of Rickettsia spp. and Borrelia spp. antibodies in patients with peripheral facial nerve palsy
description	In a retrospective study, 36 patients with peripheral facial palsy were serologically evaluated for the presence of Rickettsia spp. and Borrelia spp. antibodies. All sera underwent immunofluorescence and Western blot analysis for IgG and IgM antibodies using Rickettsia helvetica and R. felis as antigens. Anti-Borrelia antibodies were detected using a commercial ELISA detecting Borrelia burgdorferi, B. afzelii and B. garinii. Three patients (8.3%) were seropositive for Rickettsia spp. with IgG titres equal to 1:128, and six patients (16.7%) had IgM titres equal to or above 1:128. All samples with IgG/IgM titres equal to or above 1:128 were confirmed by Western Blot. Four patients (11.1%) had IgG antibodies against Borrelia at a titre level normally judged to be indicative of current infection. Two of these patients had significant IgG or IgM titres for both Rickettsia spp. and Borrelia spp., indicating co-infection. In conclusion, the findings indicate current rickettsial infection or early response at about the same degree as for Lyme borreliosis in patients with facial palsy, but they need to be further examined with a larger number of patients and paired serum analyses.
format	article
author	Katarina Wallménius Carl Påhlson Kenneth Nilsson
author_facet	Katarina Wallménius Carl Påhlson Kenneth Nilsson
author_sort	Katarina Wallménius
title	Retrospective serological study of Rickettsia spp. and Borrelia spp. antibodies in patients with peripheral facial nerve palsy
title_short	Retrospective serological study of Rickettsia spp. and Borrelia spp. antibodies in patients with peripheral facial nerve palsy
title_full	Retrospective serological study of Rickettsia spp. and Borrelia spp. antibodies in patients with peripheral facial nerve palsy
title_fullStr	Retrospective serological study of Rickettsia spp. and Borrelia spp. antibodies in patients with peripheral facial nerve palsy
title_full_unstemmed	Retrospective serological study of Rickettsia spp. and Borrelia spp. antibodies in patients with peripheral facial nerve palsy
title_sort	retrospective serological study of rickettsia spp. and borrelia spp. antibodies in patients with peripheral facial nerve palsy
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/3b8f00253bcf4d3c8f287f73fa10624b
work_keys_str_mv	AT katarinawallmenius retrospectiveserologicalstudyofrickettsiasppandborreliasppantibodiesinpatientswithperipheralfacialnervepalsy AT carlpahlson retrospectiveserologicalstudyofrickettsiasppandborreliasppantibodiesinpatientswithperipheralfacialnervepalsy AT kennethnilsson retrospectiveserologicalstudyofrickettsiasppandborreliasppantibodiesinpatientswithperipheralfacialnervepalsy
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Retrospective serological study of Rickettsia spp. and Borrelia spp. antibodies in patients with peripheral facial nerve palsy

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