APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism

APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism

Oral squamous cell carcinoma is a prevalent malignancy in Taiwan. Here, the authors show that OSCC in Taiwanese show a frequent deletion polymorphism in the cytidine deaminases gene cluster APOBEC3 resulting in increased expression of A3A, which is shown to be of clinical prognostic relevance.

Guardado en:
Detalles Bibliográficos
Autores principales: Ting-Wen Chen, Chi-Ching Lee, Hsuan Liu, Chi-Sheng Wu, Curtis R. Pickering, Po-Jung Huang, Jing Wang, Ian Yi-Feng Chang, Yuan-Ming Yeh, Chih-De Chen, Hsin-Pai Li, Ji-Dung Luo, Bertrand Chin-Ming Tan, Timothy En Haw Chan, Chuen Hsueh, Lichieh Julie Chu, Yi-Ting Chen, Bing Zhang, Chia-Yu Yang, Chih-Ching Wu, Chia-Wei Hsu, Lai-Chu See, Petrus Tang, Jau-Song Yu, Wei-Chao Liao, Wei-Fan Chiang, Henry Rodriguez, Jeffrey N. Myers, Kai-Ping Chang, Yu-Sun Chang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/3b8f11eb8dfc4c03be267e249342f6d9
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:3b8f11eb8dfc4c03be267e249342f6d9
record_format dspace
spelling oai:doaj.org-article:3b8f11eb8dfc4c03be267e249342f6d92021-12-02T14:42:43ZAPOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism10.1038/s41467-017-00493-92041-1723https://doaj.org/article/3b8f11eb8dfc4c03be267e249342f6d92017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00493-9https://doaj.org/toc/2041-1723Oral squamous cell carcinoma is a prevalent malignancy in Taiwan. Here, the authors show that OSCC in Taiwanese show a frequent deletion polymorphism in the cytidine deaminases gene cluster APOBEC3 resulting in increased expression of A3A, which is shown to be of clinical prognostic relevance.Ting-Wen ChenChi-Ching LeeHsuan LiuChi-Sheng WuCurtis R. PickeringPo-Jung HuangJing WangIan Yi-Feng ChangYuan-Ming YehChih-De ChenHsin-Pai LiJi-Dung LuoBertrand Chin-Ming TanTimothy En Haw ChanChuen HsuehLichieh Julie ChuYi-Ting ChenBing ZhangChia-Yu YangChih-Ching WuChia-Wei HsuLai-Chu SeePetrus TangJau-Song YuWei-Chao LiaoWei-Fan ChiangHenry RodriguezJeffrey N. MyersKai-Ping ChangYu-Sun ChangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ting-Wen Chen
Chi-Ching Lee
Hsuan Liu
Chi-Sheng Wu
Curtis R. Pickering
Po-Jung Huang
Jing Wang
Ian Yi-Feng Chang
Yuan-Ming Yeh
Chih-De Chen
Hsin-Pai Li
Ji-Dung Luo
Bertrand Chin-Ming Tan
Timothy En Haw Chan
Chuen Hsueh
Lichieh Julie Chu
Yi-Ting Chen
Bing Zhang
Chia-Yu Yang
Chih-Ching Wu
Chia-Wei Hsu
Lai-Chu See
Petrus Tang
Jau-Song Yu
Wei-Chao Liao
Wei-Fan Chiang
Henry Rodriguez
Jeffrey N. Myers
Kai-Ping Chang
Yu-Sun Chang
APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism
description Oral squamous cell carcinoma is a prevalent malignancy in Taiwan. Here, the authors show that OSCC in Taiwanese show a frequent deletion polymorphism in the cytidine deaminases gene cluster APOBEC3 resulting in increased expression of A3A, which is shown to be of clinical prognostic relevance.
format article
author Ting-Wen Chen
Chi-Ching Lee
Hsuan Liu
Chi-Sheng Wu
Curtis R. Pickering
Po-Jung Huang
Jing Wang
Ian Yi-Feng Chang
Yuan-Ming Yeh
Chih-De Chen
Hsin-Pai Li
Ji-Dung Luo
Bertrand Chin-Ming Tan
Timothy En Haw Chan
Chuen Hsueh
Lichieh Julie Chu
Yi-Ting Chen
Bing Zhang
Chia-Yu Yang
Chih-Ching Wu
Chia-Wei Hsu
Lai-Chu See
Petrus Tang
Jau-Song Yu
Wei-Chao Liao
Wei-Fan Chiang
Henry Rodriguez
Jeffrey N. Myers
Kai-Ping Chang
Yu-Sun Chang
author_facet Ting-Wen Chen
Chi-Ching Lee
Hsuan Liu
Chi-Sheng Wu
Curtis R. Pickering
Po-Jung Huang
Jing Wang
Ian Yi-Feng Chang
Yuan-Ming Yeh
Chih-De Chen
Hsin-Pai Li
Ji-Dung Luo
Bertrand Chin-Ming Tan
Timothy En Haw Chan
Chuen Hsueh
Lichieh Julie Chu
Yi-Ting Chen
Bing Zhang
Chia-Yu Yang
Chih-Ching Wu
Chia-Wei Hsu
Lai-Chu See
Petrus Tang
Jau-Song Yu
Wei-Chao Liao
Wei-Fan Chiang
Henry Rodriguez
Jeffrey N. Myers
Kai-Ping Chang
Yu-Sun Chang
author_sort Ting-Wen Chen
title APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism
title_short APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism
title_full APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism
title_fullStr APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism
title_full_unstemmed APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism
title_sort apobec3a is an oral cancer prognostic biomarker in taiwanese carriers of an apobec deletion polymorphism
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/3b8f11eb8dfc4c03be267e249342f6d9
work_keys_str_mv AT tingwenchen apobec3aisanoralcancerprognosticbiomarkerintaiwanesecarriersofanapobecdeletionpolymorphism
AT chichinglee apobec3aisanoralcancerprognosticbiomarkerintaiwanesecarriersofanapobecdeletionpolymorphism
AT hsuanliu apobec3aisanoralcancerprognosticbiomarkerintaiwanesecarriersofanapobecdeletionpolymorphism
AT chishengwu apobec3aisanoralcancerprognosticbiomarkerintaiwanesecarriersofanapobecdeletionpolymorphism
AT curtisrpickering apobec3aisanoralcancerprognosticbiomarkerintaiwanesecarriersofanapobecdeletionpolymorphism
AT pojunghuang apobec3aisanoralcancerprognosticbiomarkerintaiwanesecarriersofanapobecdeletionpolymorphism
AT jingwang apobec3aisanoralcancerprognosticbiomarkerintaiwanesecarriersofanapobecdeletionpolymorphism
AT ianyifengchang apobec3aisanoralcancerprognosticbiomarkerintaiwanesecarriersofanapobecdeletionpolymorphism
AT yuanmingyeh apobec3aisanoralcancerprognosticbiomarkerintaiwanesecarriersofanapobecdeletionpolymorphism
AT chihdechen apobec3aisanoralcancerprognosticbiomarkerintaiwanesecarriersofanapobecdeletionpolymorphism
AT hsinpaili apobec3aisanoralcancerprognosticbiomarkerintaiwanesecarriersofanapobecdeletionpolymorphism
AT jidungluo apobec3aisanoralcancerprognosticbiomarkerintaiwanesecarriersofanapobecdeletionpolymorphism
AT bertrandchinmingtan apobec3aisanoralcancerprognosticbiomarkerintaiwanesecarriersofanapobecdeletionpolymorphism
AT timothyenhawchan apobec3aisanoralcancerprognosticbiomarkerintaiwanesecarriersofanapobecdeletionpolymorphism
AT chuenhsueh apobec3aisanoralcancerprognosticbiomarkerintaiwanesecarriersofanapobecdeletionpolymorphism
AT lichiehjuliechu apobec3aisanoralcancerprognosticbiomarkerintaiwanesecarriersofanapobecdeletionpolymorphism
AT yitingchen apobec3aisanoralcancerprognosticbiomarkerintaiwanesecarriersofanapobecdeletionpolymorphism
AT bingzhang apobec3aisanoralcancerprognosticbiomarkerintaiwanesecarriersofanapobecdeletionpolymorphism
AT chiayuyang apobec3aisanoralcancerprognosticbiomarkerintaiwanesecarriersofanapobecdeletionpolymorphism
AT chihchingwu apobec3aisanoralcancerprognosticbiomarkerintaiwanesecarriersofanapobecdeletionpolymorphism
AT chiaweihsu apobec3aisanoralcancerprognosticbiomarkerintaiwanesecarriersofanapobecdeletionpolymorphism
AT laichusee apobec3aisanoralcancerprognosticbiomarkerintaiwanesecarriersofanapobecdeletionpolymorphism
AT petrustang apobec3aisanoralcancerprognosticbiomarkerintaiwanesecarriersofanapobecdeletionpolymorphism
AT jausongyu apobec3aisanoralcancerprognosticbiomarkerintaiwanesecarriersofanapobecdeletionpolymorphism
AT weichaoliao apobec3aisanoralcancerprognosticbiomarkerintaiwanesecarriersofanapobecdeletionpolymorphism
AT weifanchiang apobec3aisanoralcancerprognosticbiomarkerintaiwanesecarriersofanapobecdeletionpolymorphism
AT henryrodriguez apobec3aisanoralcancerprognosticbiomarkerintaiwanesecarriersofanapobecdeletionpolymorphism
AT jeffreynmyers apobec3aisanoralcancerprognosticbiomarkerintaiwanesecarriersofanapobecdeletionpolymorphism
AT kaipingchang apobec3aisanoralcancerprognosticbiomarkerintaiwanesecarriersofanapobecdeletionpolymorphism
AT yusunchang apobec3aisanoralcancerprognosticbiomarkerintaiwanesecarriersofanapobecdeletionpolymorphism
_version_ 1718389623791550464

Ejemplares similares