Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit

SAMHD1 is a critical restriction factor for HIV-1 and its antiviral activity is regulated by T592 phosphorylation. Here, Schott et al. show that the phosphatase PP2A-B55α dephosphorylates SAMHD1 during mitotic exit, rendering it antivirally active in G1 phase of primary CD4+ T cells.

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Autores principales:	Kerstin Schott, Nina V. Fuchs, Rita Derua, Bijan Mahboubi, Esther Schnellbächer, Janna Seifried, Christiane Tondera, Heike Schmitz, Caitlin Shepard, Alberto Brandariz-Nuñez, Felipe Diaz-Griffero, Andreas Reuter, Baek Kim, Veerle Janssens, Renate König
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3b8f796c4d5d4e31b78e854d8aab59b2
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spelling	oai:doaj.org-article:3b8f796c4d5d4e31b78e854d8aab59b22021-12-02T16:49:50ZDephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit10.1038/s41467-018-04671-12041-1723https://doaj.org/article/3b8f796c4d5d4e31b78e854d8aab59b22018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04671-1https://doaj.org/toc/2041-1723SAMHD1 is a critical restriction factor for HIV-1 and its antiviral activity is regulated by T592 phosphorylation. Here, Schott et al. show that the phosphatase PP2A-B55α dephosphorylates SAMHD1 during mitotic exit, rendering it antivirally active in G1 phase of primary CD4+ T cells.Kerstin SchottNina V. FuchsRita DeruaBijan MahboubiEsther SchnellbächerJanna SeifriedChristiane TonderaHeike SchmitzCaitlin ShepardAlberto Brandariz-NuñezFelipe Diaz-GrifferoAndreas ReuterBaek KimVeerle JanssensRenate KönigNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kerstin Schott Nina V. Fuchs Rita Derua Bijan Mahboubi Esther Schnellbächer Janna Seifried Christiane Tondera Heike Schmitz Caitlin Shepard Alberto Brandariz-Nuñez Felipe Diaz-Griffero Andreas Reuter Baek Kim Veerle Janssens Renate König Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit
description	SAMHD1 is a critical restriction factor for HIV-1 and its antiviral activity is regulated by T592 phosphorylation. Here, Schott et al. show that the phosphatase PP2A-B55α dephosphorylates SAMHD1 during mitotic exit, rendering it antivirally active in G1 phase of primary CD4+ T cells.
format	article
author	Kerstin Schott Nina V. Fuchs Rita Derua Bijan Mahboubi Esther Schnellbächer Janna Seifried Christiane Tondera Heike Schmitz Caitlin Shepard Alberto Brandariz-Nuñez Felipe Diaz-Griffero Andreas Reuter Baek Kim Veerle Janssens Renate König
author_facet	Kerstin Schott Nina V. Fuchs Rita Derua Bijan Mahboubi Esther Schnellbächer Janna Seifried Christiane Tondera Heike Schmitz Caitlin Shepard Alberto Brandariz-Nuñez Felipe Diaz-Griffero Andreas Reuter Baek Kim Veerle Janssens Renate König
author_sort	Kerstin Schott
title	Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit
title_short	Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit
title_full	Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit
title_fullStr	Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit
title_full_unstemmed	Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit
title_sort	dephosphorylation of the hiv-1 restriction factor samhd1 is mediated by pp2a-b55α holoenzymes during mitotic exit
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3b8f796c4d5d4e31b78e854d8aab59b2
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Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit

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