Targeting glutamine metabolism slows soft tissue sarcoma growth

Targeting glutamine metabolism slows soft tissue sarcoma growth

Glutamine is an energetic source required for the proliferation of cancer cells. Here, the authors show that soft tissue sarcomas expressing high levels of glutaminase (GLS) are particularly sensitive to glutamine starvation and GLS inhibition in tumour-bearing allograft and autochthonous mouse mode...

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Bibliographic Details
Main Authors: Pearl Lee, Dania Malik, Nicholas Perkons, Peiwei Huangyang, Sanika Khare, Seth Rhoades, Yao-Yu Gong, Michelle Burrows, Jennifer M. Finan, Itzhak Nissim, Terence P. F. Gade, Aalim M. Weljie, M. Celeste Simon
Format: article
Language:EN
Published: Nature Portfolio 2020
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Science
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Online Access:https://doaj.org/article/3b907274e9ce47de86b2c4ff4f6b6ad0
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Summary:Glutamine is an energetic source required for the proliferation of cancer cells. Here, the authors show that soft tissue sarcomas expressing high levels of glutaminase (GLS) are particularly sensitive to glutamine starvation and GLS inhibition in tumour-bearing allograft and autochthonous mouse models.

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