Targeting glutamine metabolism slows soft tissue sarcoma growth

Glutamine is an energetic source required for the proliferation of cancer cells. Here, the authors show that soft tissue sarcomas expressing high levels of glutaminase (GLS) are particularly sensitive to glutamine starvation and GLS inhibition in tumour-bearing allograft and autochthonous mouse mode...

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Autores principales:	Pearl Lee, Dania Malik, Nicholas Perkons, Peiwei Huangyang, Sanika Khare, Seth Rhoades, Yao-Yu Gong, Michelle Burrows, Jennifer M. Finan, Itzhak Nissim, Terence P. F. Gade, Aalim M. Weljie, M. Celeste Simon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3b907274e9ce47de86b2c4ff4f6b6ad0
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spelling	oai:doaj.org-article:3b907274e9ce47de86b2c4ff4f6b6ad02021-12-02T17:31:24ZTargeting glutamine metabolism slows soft tissue sarcoma growth10.1038/s41467-020-14374-12041-1723https://doaj.org/article/3b907274e9ce47de86b2c4ff4f6b6ad02020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14374-1https://doaj.org/toc/2041-1723Glutamine is an energetic source required for the proliferation of cancer cells. Here, the authors show that soft tissue sarcomas expressing high levels of glutaminase (GLS) are particularly sensitive to glutamine starvation and GLS inhibition in tumour-bearing allograft and autochthonous mouse models.Pearl LeeDania MalikNicholas PerkonsPeiwei HuangyangSanika KhareSeth RhoadesYao-Yu GongMichelle BurrowsJennifer M. FinanItzhak NissimTerence P. F. GadeAalim M. WeljieM. Celeste SimonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pearl Lee Dania Malik Nicholas Perkons Peiwei Huangyang Sanika Khare Seth Rhoades Yao-Yu Gong Michelle Burrows Jennifer M. Finan Itzhak Nissim Terence P. F. Gade Aalim M. Weljie M. Celeste Simon Targeting glutamine metabolism slows soft tissue sarcoma growth
description	Glutamine is an energetic source required for the proliferation of cancer cells. Here, the authors show that soft tissue sarcomas expressing high levels of glutaminase (GLS) are particularly sensitive to glutamine starvation and GLS inhibition in tumour-bearing allograft and autochthonous mouse models.
format	article
author	Pearl Lee Dania Malik Nicholas Perkons Peiwei Huangyang Sanika Khare Seth Rhoades Yao-Yu Gong Michelle Burrows Jennifer M. Finan Itzhak Nissim Terence P. F. Gade Aalim M. Weljie M. Celeste Simon
author_facet	Pearl Lee Dania Malik Nicholas Perkons Peiwei Huangyang Sanika Khare Seth Rhoades Yao-Yu Gong Michelle Burrows Jennifer M. Finan Itzhak Nissim Terence P. F. Gade Aalim M. Weljie M. Celeste Simon
author_sort	Pearl Lee
title	Targeting glutamine metabolism slows soft tissue sarcoma growth
title_short	Targeting glutamine metabolism slows soft tissue sarcoma growth
title_full	Targeting glutamine metabolism slows soft tissue sarcoma growth
title_fullStr	Targeting glutamine metabolism slows soft tissue sarcoma growth
title_full_unstemmed	Targeting glutamine metabolism slows soft tissue sarcoma growth
title_sort	targeting glutamine metabolism slows soft tissue sarcoma growth
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3b907274e9ce47de86b2c4ff4f6b6ad0
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Targeting glutamine metabolism slows soft tissue sarcoma growth

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