The multimorbidity of hypertension and osteoarthritis and relation with sleep quality and hyperlipemia/hyperglycemia in China’s rural population

Abstract Hypertension (HTN) and osteoarthritis (OA) are frequent in middle-aged and elderly people, and the co-occurrence of these two diseases is common. However, the pathogenesis of the multimorbidity of both diseases and the relation with sleep quality, hyperlipemia, and hyperglycemia is unclear....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Li Ran, Qi Chen, Jingyi Zhang, Xinlong Tu, Xiaodong Tan, Yuting Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3b91b46db3064412b849f43870ffed73
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3b91b46db3064412b849f43870ffed73
record_format	dspace
spelling	oai:doaj.org-article:3b91b46db3064412b849f43870ffed732021-12-02T19:02:37ZThe multimorbidity of hypertension and osteoarthritis and relation with sleep quality and hyperlipemia/hyperglycemia in China’s rural population10.1038/s41598-021-96523-02045-2322https://doaj.org/article/3b91b46db3064412b849f43870ffed732021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96523-0https://doaj.org/toc/2045-2322Abstract Hypertension (HTN) and osteoarthritis (OA) are frequent in middle-aged and elderly people, and the co-occurrence of these two diseases is common. However, the pathogenesis of the multimorbidity of both diseases and the relation with sleep quality, hyperlipemia, and hyperglycemia is unclear. We conducted a cross-sectional study to make sense of the multimorbidity of HTN and OA and the relation with sleep quality, hyperlipemia, and hyperglycemia. The relation between sleep quality and OA and its joint effect with hyperlipemia or hyperglycemia was evaluated with logistic regression models. The additive interaction was assessed with the relative excess risk due to interaction (REEI), the attributable proportion (AP), and the synergy index (S). According to this research in a remote rural area, approximately 34.2% of HTN patients are accompanied with OA and 49.1% are suffering poor sleep. Both hyperlipemia/hyperglycemia and sleep quality were related to OA prevalence with crude ORs of 1.43 (95% CI 1.014–2.029) and 1.89 (95% CI 1.411–2.519, P < 0.001) respectively. An observed additive effect was found greater than the sum of the effects of sleep quality and hyperlipemia/hyperglycemia posed on OA prevalence alone. This additive interaction was observed in females (OR = 3.19, 95% CI 1.945–5.237) as well as males ≥ 65 years old (OR = 2.78, 95% CI 1.693–4.557), with RERI, AP, and S significant. Therefore, poor sleep and hyperlipemia/hyperglycemia are associated with OA, and further studies on the additive interaction among females and males ≥ 65 are warranted.Li RanQi ChenJingyi ZhangXinlong TuXiaodong TanYuting ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Li Ran Qi Chen Jingyi Zhang Xinlong Tu Xiaodong Tan Yuting Zhang The multimorbidity of hypertension and osteoarthritis and relation with sleep quality and hyperlipemia/hyperglycemia in China’s rural population
description	Abstract Hypertension (HTN) and osteoarthritis (OA) are frequent in middle-aged and elderly people, and the co-occurrence of these two diseases is common. However, the pathogenesis of the multimorbidity of both diseases and the relation with sleep quality, hyperlipemia, and hyperglycemia is unclear. We conducted a cross-sectional study to make sense of the multimorbidity of HTN and OA and the relation with sleep quality, hyperlipemia, and hyperglycemia. The relation between sleep quality and OA and its joint effect with hyperlipemia or hyperglycemia was evaluated with logistic regression models. The additive interaction was assessed with the relative excess risk due to interaction (REEI), the attributable proportion (AP), and the synergy index (S). According to this research in a remote rural area, approximately 34.2% of HTN patients are accompanied with OA and 49.1% are suffering poor sleep. Both hyperlipemia/hyperglycemia and sleep quality were related to OA prevalence with crude ORs of 1.43 (95% CI 1.014–2.029) and 1.89 (95% CI 1.411–2.519, P < 0.001) respectively. An observed additive effect was found greater than the sum of the effects of sleep quality and hyperlipemia/hyperglycemia posed on OA prevalence alone. This additive interaction was observed in females (OR = 3.19, 95% CI 1.945–5.237) as well as males ≥ 65 years old (OR = 2.78, 95% CI 1.693–4.557), with RERI, AP, and S significant. Therefore, poor sleep and hyperlipemia/hyperglycemia are associated with OA, and further studies on the additive interaction among females and males ≥ 65 are warranted.
format	article
author	Li Ran Qi Chen Jingyi Zhang Xinlong Tu Xiaodong Tan Yuting Zhang
author_facet	Li Ran Qi Chen Jingyi Zhang Xinlong Tu Xiaodong Tan Yuting Zhang
author_sort	Li Ran
title	The multimorbidity of hypertension and osteoarthritis and relation with sleep quality and hyperlipemia/hyperglycemia in China’s rural population
title_short	The multimorbidity of hypertension and osteoarthritis and relation with sleep quality and hyperlipemia/hyperglycemia in China’s rural population
title_full	The multimorbidity of hypertension and osteoarthritis and relation with sleep quality and hyperlipemia/hyperglycemia in China’s rural population
title_fullStr	The multimorbidity of hypertension and osteoarthritis and relation with sleep quality and hyperlipemia/hyperglycemia in China’s rural population
title_full_unstemmed	The multimorbidity of hypertension and osteoarthritis and relation with sleep quality and hyperlipemia/hyperglycemia in China’s rural population
title_sort	multimorbidity of hypertension and osteoarthritis and relation with sleep quality and hyperlipemia/hyperglycemia in china’s rural population
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3b91b46db3064412b849f43870ffed73
work_keys_str_mv	AT liran themultimorbidityofhypertensionandosteoarthritisandrelationwithsleepqualityandhyperlipemiahyperglycemiainchinasruralpopulation AT qichen themultimorbidityofhypertensionandosteoarthritisandrelationwithsleepqualityandhyperlipemiahyperglycemiainchinasruralpopulation AT jingyizhang themultimorbidityofhypertensionandosteoarthritisandrelationwithsleepqualityandhyperlipemiahyperglycemiainchinasruralpopulation AT xinlongtu themultimorbidityofhypertensionandosteoarthritisandrelationwithsleepqualityandhyperlipemiahyperglycemiainchinasruralpopulation AT xiaodongtan themultimorbidityofhypertensionandosteoarthritisandrelationwithsleepqualityandhyperlipemiahyperglycemiainchinasruralpopulation AT yutingzhang themultimorbidityofhypertensionandosteoarthritisandrelationwithsleepqualityandhyperlipemiahyperglycemiainchinasruralpopulation AT liran multimorbidityofhypertensionandosteoarthritisandrelationwithsleepqualityandhyperlipemiahyperglycemiainchinasruralpopulation AT qichen multimorbidityofhypertensionandosteoarthritisandrelationwithsleepqualityandhyperlipemiahyperglycemiainchinasruralpopulation AT jingyizhang multimorbidityofhypertensionandosteoarthritisandrelationwithsleepqualityandhyperlipemiahyperglycemiainchinasruralpopulation AT xinlongtu multimorbidityofhypertensionandosteoarthritisandrelationwithsleepqualityandhyperlipemiahyperglycemiainchinasruralpopulation AT xiaodongtan multimorbidityofhypertensionandosteoarthritisandrelationwithsleepqualityandhyperlipemiahyperglycemiainchinasruralpopulation AT yutingzhang multimorbidityofhypertensionandosteoarthritisandrelationwithsleepqualityandhyperlipemiahyperglycemiainchinasruralpopulation
_version_	1718377203417219072

The multimorbidity of hypertension and osteoarthritis and relation with sleep quality and hyperlipemia/hyperglycemia in China’s rural population

Ejemplares similares