Clinical Trials and Outcome Measures in Adults With Hearing Loss

Clinical trials are designed to evaluate interventions that prevent, diagnose or treat a health condition and provide the evidence base for improving practice in health care. Many health professionals, including those working within or allied to hearing health, are expected to conduct or contribute...

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Autores principales:	Kevin J. Munro, William M. Whitmer, Antje Heinrich
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	clinical trials outcome measures minimal important difference interventions hearing loss hearing-related outcomes Psychology BF1-990
Acceso en línea:	https://doaj.org/article/3b942b271a204190ab6e0ece85eba316
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spelling	oai:doaj.org-article:3b942b271a204190ab6e0ece85eba3162021-11-05T05:33:59ZClinical Trials and Outcome Measures in Adults With Hearing Loss1664-107810.3389/fpsyg.2021.733060https://doaj.org/article/3b942b271a204190ab6e0ece85eba3162021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyg.2021.733060/fullhttps://doaj.org/toc/1664-1078Clinical trials are designed to evaluate interventions that prevent, diagnose or treat a health condition and provide the evidence base for improving practice in health care. Many health professionals, including those working within or allied to hearing health, are expected to conduct or contribute to clinical trials. Recent systematic reviews of clinical trials reveal a dearth of high quality evidence in almost all areas of hearing health practice. By providing an overview of important steps and considerations concerning the design, analysis and conduct of trials, this article aims to give guidance to hearing health professionals about the key elements that define the quality of a trial. The article starts out by situating clinical trials within the greater scope of clinical evidence, then discusses the elements of a PICO-style research question. Subsequently, various methodological considerations are discussed including design, randomization, blinding, and outcome measures. Because the literature on outcome measures within hearing health is as confusing as it is voluminous, particular focus is given to discussing how hearing-related outcome measures affect clinical trials. This focus encompasses how the choice of measurement instrument(s) affects interpretation, how the accuracy of a measure can be estimated, how this affects the interpretation of results, and if differences are statistically, perceptually and/or clinically meaningful to the target population, people with hearing loss.Kevin J. MunroKevin J. MunroWilliam M. WhitmerWilliam M. WhitmerAntje HeinrichFrontiers Media S.A.articleclinical trialsoutcome measuresminimal important differenceinterventionshearing losshearing-related outcomesPsychologyBF1-990ENFrontiers in Psychology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	clinical trials outcome measures minimal important difference interventions hearing loss hearing-related outcomes Psychology BF1-990
spellingShingle	clinical trials outcome measures minimal important difference interventions hearing loss hearing-related outcomes Psychology BF1-990 Kevin J. Munro Kevin J. Munro William M. Whitmer William M. Whitmer Antje Heinrich Clinical Trials and Outcome Measures in Adults With Hearing Loss
description	Clinical trials are designed to evaluate interventions that prevent, diagnose or treat a health condition and provide the evidence base for improving practice in health care. Many health professionals, including those working within or allied to hearing health, are expected to conduct or contribute to clinical trials. Recent systematic reviews of clinical trials reveal a dearth of high quality evidence in almost all areas of hearing health practice. By providing an overview of important steps and considerations concerning the design, analysis and conduct of trials, this article aims to give guidance to hearing health professionals about the key elements that define the quality of a trial. The article starts out by situating clinical trials within the greater scope of clinical evidence, then discusses the elements of a PICO-style research question. Subsequently, various methodological considerations are discussed including design, randomization, blinding, and outcome measures. Because the literature on outcome measures within hearing health is as confusing as it is voluminous, particular focus is given to discussing how hearing-related outcome measures affect clinical trials. This focus encompasses how the choice of measurement instrument(s) affects interpretation, how the accuracy of a measure can be estimated, how this affects the interpretation of results, and if differences are statistically, perceptually and/or clinically meaningful to the target population, people with hearing loss.
format	article
author	Kevin J. Munro Kevin J. Munro William M. Whitmer William M. Whitmer Antje Heinrich
author_facet	Kevin J. Munro Kevin J. Munro William M. Whitmer William M. Whitmer Antje Heinrich
author_sort	Kevin J. Munro
title	Clinical Trials and Outcome Measures in Adults With Hearing Loss
title_short	Clinical Trials and Outcome Measures in Adults With Hearing Loss
title_full	Clinical Trials and Outcome Measures in Adults With Hearing Loss
title_fullStr	Clinical Trials and Outcome Measures in Adults With Hearing Loss
title_full_unstemmed	Clinical Trials and Outcome Measures in Adults With Hearing Loss
title_sort	clinical trials and outcome measures in adults with hearing loss
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/3b942b271a204190ab6e0ece85eba316
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Clinical Trials and Outcome Measures in Adults With Hearing Loss

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