Effect of Adding Midazolam to Dual Prophylaxis for Preventing Postoperative Nausea and Vomiting

Multimodal prophylaxis for postoperative nausea and vomiting (PONV) has been recommended, even in low-risk patients. Midazolam is known to have antiemetic properties. We researched the effects of adding midazolam to the dual prophylaxis of ondansetron and dexamethasone on PONV after gynecologic lapa...

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Autores principales:	Jiyoung Lee, In Kyong Yi, Jung Youn Han, Eun Duc Na, Chunghyun Park, Jong Yeop Kim
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	antiemetics midazolam postoperative nausea and vomiting prophylaxis gynecology laparoscopy Medicine R
Acceso en línea:	https://doaj.org/article/3b99f8c27b4341eb8535bf500b036201
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spelling	oai:doaj.org-article:3b99f8c27b4341eb8535bf500b0362012021-11-11T17:31:19ZEffect of Adding Midazolam to Dual Prophylaxis for Preventing Postoperative Nausea and Vomiting10.3390/jcm102148572077-0383https://doaj.org/article/3b99f8c27b4341eb8535bf500b0362012021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4857https://doaj.org/toc/2077-0383Multimodal prophylaxis for postoperative nausea and vomiting (PONV) has been recommended, even in low-risk patients. Midazolam is known to have antiemetic properties. We researched the effects of adding midazolam to the dual prophylaxis of ondansetron and dexamethasone on PONV after gynecologic laparoscopy. In this prospective, randomized, double-blinded trial, 144 patients undergoing gynecological laparoscopic surgery under sevoflurane anesthesia were randomized to receive either normal saline (control group, <i>n</i> = 72) or midazolam 0.05 mg/kg (midazolam group, <i>n</i> = 72) intravenously at pre-induction. All patients were administered dexamethasone 4 mg at induction and ondansetron 4 mg at the completion of the laparoscopy, intravenously. The primary outcome was the incidence of complete response, which implied the absence of PONV without rescue antiemetic requirement until 24 h post-surgery. The complete response during the 24 h following laparoscopy was similar between the two groups: 41 patients (59%) in the control group and 48 patients (72%) in the midazolam group (<i>p</i> = 0.11). The incidence of nausea, severe nausea, retching/vomiting, and administration of rescue antiemetic was comparable between the two groups. The addition of 0.05 mg/kg midazolam at pre-induction to the dual prophylaxis had no additive preventive effect on PONV after gynecologic laparoscopy.Jiyoung LeeIn Kyong YiJung Youn HanEun Duc NaChunghyun ParkJong Yeop KimMDPI AGarticleantiemeticsmidazolampostoperative nausea and vomitingprophylaxisgynecologylaparoscopyMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4857, p 4857 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antiemetics midazolam postoperative nausea and vomiting prophylaxis gynecology laparoscopy Medicine R
spellingShingle	antiemetics midazolam postoperative nausea and vomiting prophylaxis gynecology laparoscopy Medicine R Jiyoung Lee In Kyong Yi Jung Youn Han Eun Duc Na Chunghyun Park Jong Yeop Kim Effect of Adding Midazolam to Dual Prophylaxis for Preventing Postoperative Nausea and Vomiting
description	Multimodal prophylaxis for postoperative nausea and vomiting (PONV) has been recommended, even in low-risk patients. Midazolam is known to have antiemetic properties. We researched the effects of adding midazolam to the dual prophylaxis of ondansetron and dexamethasone on PONV after gynecologic laparoscopy. In this prospective, randomized, double-blinded trial, 144 patients undergoing gynecological laparoscopic surgery under sevoflurane anesthesia were randomized to receive either normal saline (control group, <i>n</i> = 72) or midazolam 0.05 mg/kg (midazolam group, <i>n</i> = 72) intravenously at pre-induction. All patients were administered dexamethasone 4 mg at induction and ondansetron 4 mg at the completion of the laparoscopy, intravenously. The primary outcome was the incidence of complete response, which implied the absence of PONV without rescue antiemetic requirement until 24 h post-surgery. The complete response during the 24 h following laparoscopy was similar between the two groups: 41 patients (59%) in the control group and 48 patients (72%) in the midazolam group (<i>p</i> = 0.11). The incidence of nausea, severe nausea, retching/vomiting, and administration of rescue antiemetic was comparable between the two groups. The addition of 0.05 mg/kg midazolam at pre-induction to the dual prophylaxis had no additive preventive effect on PONV after gynecologic laparoscopy.
format	article
author	Jiyoung Lee In Kyong Yi Jung Youn Han Eun Duc Na Chunghyun Park Jong Yeop Kim
author_facet	Jiyoung Lee In Kyong Yi Jung Youn Han Eun Duc Na Chunghyun Park Jong Yeop Kim
author_sort	Jiyoung Lee
title	Effect of Adding Midazolam to Dual Prophylaxis for Preventing Postoperative Nausea and Vomiting
title_short	Effect of Adding Midazolam to Dual Prophylaxis for Preventing Postoperative Nausea and Vomiting
title_full	Effect of Adding Midazolam to Dual Prophylaxis for Preventing Postoperative Nausea and Vomiting
title_fullStr	Effect of Adding Midazolam to Dual Prophylaxis for Preventing Postoperative Nausea and Vomiting
title_full_unstemmed	Effect of Adding Midazolam to Dual Prophylaxis for Preventing Postoperative Nausea and Vomiting
title_sort	effect of adding midazolam to dual prophylaxis for preventing postoperative nausea and vomiting
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3b99f8c27b4341eb8535bf500b036201
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Effect of Adding Midazolam to Dual Prophylaxis for Preventing Postoperative Nausea and Vomiting

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