Dynamic mechanochemical feedback between curved membranes and BAR protein self-organization

Amphiphysin BAR proteins reshape membranes, but the dynamics of the process remained unexplored. Here, the authors show through experiment and modelling that reshaping depends on the initial template shape, occurs even at low initial curvature, and involves the coexistence of isotropic and nematic s...

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Autores principales: Anabel-Lise Le Roux, Caterina Tozzi, Nikhil Walani, Xarxa Quiroga, Dobryna Zalvidea, Xavier Trepat, Margarita Staykova, Marino Arroyo, Pere Roca-Cusachs
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/3b9d4c84264247a5a7e94d78fc4c48cf
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Sumario:Amphiphysin BAR proteins reshape membranes, but the dynamics of the process remained unexplored. Here, the authors show through experiment and modelling that reshaping depends on the initial template shape, occurs even at low initial curvature, and involves the coexistence of isotropic and nematic states.