A defined mechanistic correlate of protection against Plasmodium falciparum malaria in non-human primates

A defined mechanistic correlate of protection against Plasmodium falciparum malaria in non-human primates

Proof of protection against blood-stage P. falciparum malaria by a single immunological mechanism has been elusive. Here, using engineered anti-PfRH5 chimeric monoclonal antibodies in non-human primates, the authors show that high levels of merozoite-neutralizing antibodies can achieve protection.

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Autores principales: Alexander D. Douglas, G. Christian Baldeviano, Jing Jin, Kazutoyo Miura, Ababacar Diouf, Zenon A. Zenonos, Julio A. Ventocilla, Sarah E. Silk, Jennifer M. Marshall, Daniel G. W. Alanine, Chuan Wang, Nick J. Edwards, Karina P. Leiva, Luis A. Gomez-Puerta, Carmen M. Lucas, Gavin J. Wright, Carole A. Long, Joseph M. Royal, Simon J. Draper
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/3b9dfa5270d844208baf55b37a0ad4bc
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spelling oai:doaj.org-article:3b9dfa5270d844208baf55b37a0ad4bc2021-12-02T16:58:27ZA defined mechanistic correlate of protection against Plasmodium falciparum malaria in non-human primates10.1038/s41467-019-09894-42041-1723https://doaj.org/article/3b9dfa5270d844208baf55b37a0ad4bc2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09894-4https://doaj.org/toc/2041-1723Proof of protection against blood-stage P. falciparum malaria by a single immunological mechanism has been elusive. Here, using engineered anti-PfRH5 chimeric monoclonal antibodies in non-human primates, the authors show that high levels of merozoite-neutralizing antibodies can achieve protection.Alexander D. DouglasG. Christian BaldevianoJing JinKazutoyo MiuraAbabacar DioufZenon A. ZenonosJulio A. VentocillaSarah E. SilkJennifer M. MarshallDaniel G. W. AlanineChuan WangNick J. EdwardsKarina P. LeivaLuis A. Gomez-PuertaCarmen M. LucasGavin J. WrightCarole A. LongJoseph M. RoyalSimon J. DraperNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Alexander D. Douglas
G. Christian Baldeviano
Jing Jin
Kazutoyo Miura
Ababacar Diouf
Zenon A. Zenonos
Julio A. Ventocilla
Sarah E. Silk
Jennifer M. Marshall
Daniel G. W. Alanine
Chuan Wang
Nick J. Edwards
Karina P. Leiva
Luis A. Gomez-Puerta
Carmen M. Lucas
Gavin J. Wright
Carole A. Long
Joseph M. Royal
Simon J. Draper
A defined mechanistic correlate of protection against Plasmodium falciparum malaria in non-human primates
description Proof of protection against blood-stage P. falciparum malaria by a single immunological mechanism has been elusive. Here, using engineered anti-PfRH5 chimeric monoclonal antibodies in non-human primates, the authors show that high levels of merozoite-neutralizing antibodies can achieve protection.
format article
author Alexander D. Douglas
G. Christian Baldeviano
Jing Jin
Kazutoyo Miura
Ababacar Diouf
Zenon A. Zenonos
Julio A. Ventocilla
Sarah E. Silk
Jennifer M. Marshall
Daniel G. W. Alanine
Chuan Wang
Nick J. Edwards
Karina P. Leiva
Luis A. Gomez-Puerta
Carmen M. Lucas
Gavin J. Wright
Carole A. Long
Joseph M. Royal
Simon J. Draper
author_facet Alexander D. Douglas
G. Christian Baldeviano
Jing Jin
Kazutoyo Miura
Ababacar Diouf
Zenon A. Zenonos
Julio A. Ventocilla
Sarah E. Silk
Jennifer M. Marshall
Daniel G. W. Alanine
Chuan Wang
Nick J. Edwards
Karina P. Leiva
Luis A. Gomez-Puerta
Carmen M. Lucas
Gavin J. Wright
Carole A. Long
Joseph M. Royal
Simon J. Draper
author_sort Alexander D. Douglas
title A defined mechanistic correlate of protection against Plasmodium falciparum malaria in non-human primates
title_short A defined mechanistic correlate of protection against Plasmodium falciparum malaria in non-human primates
title_full A defined mechanistic correlate of protection against Plasmodium falciparum malaria in non-human primates
title_fullStr A defined mechanistic correlate of protection against Plasmodium falciparum malaria in non-human primates
title_full_unstemmed A defined mechanistic correlate of protection against Plasmodium falciparum malaria in non-human primates
title_sort defined mechanistic correlate of protection against plasmodium falciparum malaria in non-human primates
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/3b9dfa5270d844208baf55b37a0ad4bc
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