Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis

Imbalanced proteostasis is associated with diverse diseases, including ischemia/reperfusion injury in the heart. Here the authors show that the ATF6 arm of the unfolded protein response can be pharmacologically activated with a small molecule in vivo, providing protection from ischemia/reperfusion i...

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Auteurs principaux: Erik A. Blackwood, Khalid Azizi, Donna J. Thuerauf, Ryan J. Paxman, Lars Plate, Jeffery W. Kelly, R. Luke Wiseman, Christopher C. Glembotski
Format: article
Langue:EN
Publié: Nature Portfolio 2019
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Accès en ligne:https://doaj.org/article/3ba71f4e4b844e449ec46f1e2075895f
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