MENINGOCOCCUS GROWTH STIMULATORS FOR MENINGITIS DIAGNOSTICS BASED ON 2-HYDROXYLALKYLAMINE SALTS

The methods for the synthesis of 4-(4 '-nitrophenyl)-L-(+)-treo- and 2,8-dimethyl-4-(4 '-nitro-phenyl)-L-(+)-treo- 1-aza-3,7-dioxabicyclo-[3,3,0]octanes as well as iodomethylates of L-(+)-treo-, D-(-)-treo- and. D-(-)-, L-(+)-treo -4-(4 '-nitrophenyl)-1-aza-3,7-dioxabicyclo-[3,3,0]-oc...

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Autores principales:	A. N. Mirskova, S. N. Adamovich, E. Ya. Vinogradov, R. G. Mirskov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2012
Materias:	meningococcus growth stimulators medium nutritium Science Q
Acceso en línea:	https://doaj.org/article/3ba846f4dc7241e49f2439737cfcbcbd
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spelling	oai:doaj.org-article:3ba846f4dc7241e49f2439737cfcbcbd2021-11-23T06:14:24ZMENINGOCOCCUS GROWTH STIMULATORS FOR MENINGITIS DIAGNOSTICS BASED ON 2-HYDROXYLALKYLAMINE SALTS2541-94202587-9596https://doaj.org/article/3ba846f4dc7241e49f2439737cfcbcbd2012-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1147https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The methods for the synthesis of 4-(4 '-nitrophenyl)-L-(+)-treo- and 2,8-dimethyl-4-(4 '-nitro-phenyl)-L-(+)-treo- 1-aza-3,7-dioxabicyclo-[3,3,0]octanes as well as iodomethylates of L-(+)-treo-, D-(-)-treo- and. D-(-)-, L-(+)-treo -4-(4 '-nitrophenyl)-1-aza-3,7-dioxabicyclo-[3,3,0]-octanes have been developed. It has been shown for the first time that optically isomeric iodo-methylates of 4-(4 '-nitrophenyl)-1-aza-3,7-dioxabicyclo[3,3,0]octanes possess high growth-stimulating activity with respect to meningococcus strains isolated from cerebrospinal fluid of patients thus indicating the possibility of these compounds application for qualitative diagnostics of meningitis. A method for the preparation of elective «Dry medium nutritium. ad. meningococcos siccum» for isolation and. cultivation of meningococci has been elaborated. Methods for the synthesis of novel potential stimulators of microorganisms growth have been worked out on the basis of biologically active aryloxy(arylsulfanyl)acetic acids and. waste of Levomecytin (Chloramphenicol) production, «L-treoamine».A. N. MirskovaS. N. AdamovichE. Ya. VinogradovR. G. MirskovScientific Сentre for Family Health and Human Reproduction Problemsarticlemeningococcus growth stimulatorsmedium nutritiumScienceQRUActa Biomedica Scientifica, Vol 0, Iss 5(1), Pp 276-280 (2012)
institution	DOAJ
collection	DOAJ
language	RU
topic	meningococcus growth stimulators medium nutritium Science Q
spellingShingle	meningococcus growth stimulators medium nutritium Science Q A. N. Mirskova S. N. Adamovich E. Ya. Vinogradov R. G. Mirskov MENINGOCOCCUS GROWTH STIMULATORS FOR MENINGITIS DIAGNOSTICS BASED ON 2-HYDROXYLALKYLAMINE SALTS
description	The methods for the synthesis of 4-(4 '-nitrophenyl)-L-(+)-treo- and 2,8-dimethyl-4-(4 '-nitro-phenyl)-L-(+)-treo- 1-aza-3,7-dioxabicyclo-[3,3,0]octanes as well as iodomethylates of L-(+)-treo-, D-(-)-treo- and. D-(-)-, L-(+)-treo -4-(4 '-nitrophenyl)-1-aza-3,7-dioxabicyclo-[3,3,0]-octanes have been developed. It has been shown for the first time that optically isomeric iodo-methylates of 4-(4 '-nitrophenyl)-1-aza-3,7-dioxabicyclo[3,3,0]octanes possess high growth-stimulating activity with respect to meningococcus strains isolated from cerebrospinal fluid of patients thus indicating the possibility of these compounds application for qualitative diagnostics of meningitis. A method for the preparation of elective «Dry medium nutritium. ad. meningococcos siccum» for isolation and. cultivation of meningococci has been elaborated. Methods for the synthesis of novel potential stimulators of microorganisms growth have been worked out on the basis of biologically active aryloxy(arylsulfanyl)acetic acids and. waste of Levomecytin (Chloramphenicol) production, «L-treoamine».
format	article
author	A. N. Mirskova S. N. Adamovich E. Ya. Vinogradov R. G. Mirskov
author_facet	A. N. Mirskova S. N. Adamovich E. Ya. Vinogradov R. G. Mirskov
author_sort	A. N. Mirskova
title	MENINGOCOCCUS GROWTH STIMULATORS FOR MENINGITIS DIAGNOSTICS BASED ON 2-HYDROXYLALKYLAMINE SALTS
title_short	MENINGOCOCCUS GROWTH STIMULATORS FOR MENINGITIS DIAGNOSTICS BASED ON 2-HYDROXYLALKYLAMINE SALTS
title_full	MENINGOCOCCUS GROWTH STIMULATORS FOR MENINGITIS DIAGNOSTICS BASED ON 2-HYDROXYLALKYLAMINE SALTS
title_fullStr	MENINGOCOCCUS GROWTH STIMULATORS FOR MENINGITIS DIAGNOSTICS BASED ON 2-HYDROXYLALKYLAMINE SALTS
title_full_unstemmed	MENINGOCOCCUS GROWTH STIMULATORS FOR MENINGITIS DIAGNOSTICS BASED ON 2-HYDROXYLALKYLAMINE SALTS
title_sort	meningococcus growth stimulators for meningitis diagnostics based on 2-hydroxylalkylamine salts
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2012
url	https://doaj.org/article/3ba846f4dc7241e49f2439737cfcbcbd
work_keys_str_mv	AT anmirskova meningococcusgrowthstimulatorsformeningitisdiagnosticsbasedon2hydroxylalkylaminesalts AT snadamovich meningococcusgrowthstimulatorsformeningitisdiagnosticsbasedon2hydroxylalkylaminesalts AT eyavinogradov meningococcusgrowthstimulatorsformeningitisdiagnosticsbasedon2hydroxylalkylaminesalts AT rgmirskov meningococcusgrowthstimulatorsformeningitisdiagnosticsbasedon2hydroxylalkylaminesalts
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MENINGOCOCCUS GROWTH STIMULATORS FOR MENINGITIS DIAGNOSTICS BASED ON 2-HYDROXYLALKYLAMINE SALTS

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