Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Known genetic loci account for only a fraction of the genetic contribution to Alzheimer’s disease. Here, the authors have performed a large genome-wide meta-analysis comprising 409,435 individuals to discover 6 new loci and demonstrate the efficacy of an Alzheimer’s disease polygenic risk score.

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Detalles Bibliográficos
Autores principales:	Itziar de Rojas, Sonia Moreno-Grau, Niccolo Tesi, Benjamin Grenier-Boley, Victor Andrade, Iris E. Jansen, Nancy L. Pedersen, Najada Stringa, Anna Zettergren, Isabel Hernández, Laura Montrreal, Carmen Antúnez, Anna Antonell, Rick M. Tankard, Joshua C. Bis, Rebecca Sims, Céline Bellenguez, Inés Quintela, Antonio González-Perez, Miguel Calero, Emilio Franco-Macías, Juan Macías, Rafael Blesa, Laura Cervera-Carles, Manuel Menéndez-González, Ana Frank-García, Jose Luís Royo, Fermin Moreno, Raquel Huerto Vilas, Miquel Baquero, Mónica Diez-Fairen, Carmen Lage, Sebastián García-Madrona, Pablo García-González, Emilio Alarcón-Martín, Sergi Valero, Oscar Sotolongo-Grau, Abbe Ullgren, Adam C. Naj, Afina W. Lemstra, Alba Benaque, Alba Pérez-Cordón, Alberto Benussi, Alberto Rábano, Alessandro Padovani, Alessio Squassina, Alexandre de Mendonça, Alfonso Arias Pastor, Almar A. L. Kok, Alun Meggy, Ana Belén Pastor, Ana Espinosa, Anaïs Corma-Gómez, Angel Martín Montes, Ángela Sanabria, Anita L. DeStefano, Anja Schneider, Annakaisa Haapasalo, Anne Kinhult Ståhlbom, Anne Tybjærg-Hansen, Annette M. Hartmann, Annika Spottke, Arturo Corbatón-Anchuelo, Arvid Rongve, Barbara Borroni, Beatrice Arosio, Benedetta Nacmias, Børge G. Nordestgaard, Brian W. Kunkle, Camille Charbonnier, Carla Abdelnour, Carlo Masullo, Carmen Martínez Rodríguez, Carmen Muñoz-Fernandez, Carole Dufouil, Caroline Graff, Catarina B. Ferreira, Caterina Chillotti, Chandra A. Reynolds, Chiara Fenoglio, Christine Van Broeckhoven, Christopher Clark, Claudia Pisanu, Claudia L. Satizabal, Clive Holmes, Dolores Buiza-Rueda, Dag Aarsland, Dan Rujescu, Daniel Alcolea, Daniela Galimberti, David Wallon, Davide Seripa, Edna Grünblatt, Efthimios Dardiotis, Emrah Düzel, Elio Scarpini, Elisa Conti, Elisa Rubino, Ellen Gelpi, Eloy Rodriguez-Rodriguez, Emmanuelle Duron, Eric Boerwinkle, Evelyn Ferri, Fabrizio Tagliavini, Fahri Küçükali, Florence Pasquier, Florentino Sanchez-Garcia, Francesca Mangialasche, Frank Jessen, Gaël Nicolas, Geir Selbæk, Gemma Ortega, Geneviève Chêne, Georgios Hadjigeorgiou, Giacomina Rossi, Gianfranco Spalletta, Giorgio Giaccone, Giulia Grande, Giuliano Binetti, Goran Papenberg, Harald Hampel, Henri Bailly, Henrik Zetterberg, Hilkka Soininen, Ida K. Karlsson, Ignacio Alvarez, Ildebrando Appollonio, Ina Giegling, Ingmar Skoog, Ingvild Saltvedt, Innocenzo Rainero, Irene Rosas Allende, Jakub Hort, Janine Diehl-Schmid, Jasper Van Dongen, Jean-Sebastien Vidal, Jenni Lehtisalo, Jens Wiltfang, Jesper Qvist Thomassen, Johannes Kornhuber, Jonathan L. Haines, Jonathan Vogelgsang, Juan A. Pineda, Juan Fortea, Julius Popp, Jürgen Deckert, Katharina Buerger, Kevin Morgan, Klaus Fließbach, Kristel Sleegers, Laura Molina-Porcel, Lena Kilander, Leonie Weinhold, Lindsay A. Farrer, Li-San Wang, Luca Kleineidam, Lucia Farotti, Lucilla Parnetti, Lucio Tremolizzo, Lucrezia Hausner, Luisa Benussi, Lutz Froelich, M. Arfan Ikram, M. Candida Deniz-Naranjo, Magda Tsolaki, Maitée Rosende-Roca, Malin Löwenmark, Marc Hulsman, Marco Spallazzi, Margaret A. Pericak-Vance, Margaret Esiri, María Bernal Sánchez-Arjona, Maria Carolina Dalmasso, María Teresa Martínez-Larrad, Marina Arcaro, Markus M. Nöthen, Marta Fernández-Fuertes, Martin Dichgans, Martin Ingelsson, Martin J. Herrmann, Martin Scherer, Martin Vyhnalek, Mary H. Kosmidis, Mary Yannakoulia, Matthias Schmid, Michael Ewers, Michael T. Heneka, Michael Wagner, Michela Scamosci, Miia Kivipelto, Mikko Hiltunen, Miren Zulaica, Montserrat Alegret, Myriam Fornage, Natalia Roberto, Natasja M. van Schoor, Nazib M. Seidu, Nerisa Banaj, Nicola J. Armstrong, Nikolaos Scarmeas, Norbert Scherbaum, Oliver Goldhardt, Oliver Hanon, Oliver Peters, Olivia Anna Skrobot, Olivier Quenez, Ondrej Lerch, Paola Bossù, Paolo Caffarra, Paolo Dionigi Rossi, Paraskevi Sakka, Per Hoffmann, Peter A. Holmans, Peter Fischer, Peter Riederer, Qiong Yang, Rachel Marshall, Rajesh N. Kalaria, Richard Mayeux, Rik Vandenberghe, Roberta Cecchetti, Roberta Ghidoni, Ruth Frikke-Schmidt, Sandro Sorbi, Sara Hägg, Sebastiaan Engelborghs, Seppo Helisalmi, Sigrid Botne Sando, Silke Kern, Silvana Archetti, Silvia Boschi, Silvia Fostinelli, Silvia Gil, Silvia Mendoza, Simon Mead, Simona Ciccone, Srdjan Djurovic, Stefanie Heilmann-Heimbach, Steffi Riedel-Heller, Teemu Kuulasmaa, Teodoro del Ser, Thibaud Lebouvier, Thomas Polak, Tiia Ngandu, Timo Grimmer, Valentina Bessi, Valentina Escott-Price, Vilmantas Giedraitis, Vincent Deramecourt, Wolfgang Maier, Xueqiu Jian, Yolande A. L. Pijnenburg, EADB contributors, The GR@ACE study group, DEGESCO consortium, IGAP (ADGC, CHARGE, EADI, GERAD), PGC-ALZ consortia, Patrick Gavin Kehoe, Guillermo Garcia-Ribas, Pascual Sánchez-Juan, Pau Pastor, Jordi Pérez-Tur, Gerard Piñol-Ripoll, Adolfo Lopez de Munain, Jose María García-Alberca, María J. Bullido, Victoria Álvarez, Alberto Lleó, Luis M. Real, Pablo Mir, Miguel Medina, Philip Scheltens, Henne Holstege, Marta Marquié, María Eugenia Sáez, Ángel Carracedo, Philippe Amouyel, Gerard D. Schellenberg, Julie Williams, Sudha Seshadri, Cornelia M. van Duijn, Karen A. Mather, Raquel Sánchez-Valle, Manuel Serrano-Ríos, Adelina Orellana, Lluís Tárraga, Kaj Blennow, Martijn Huisman, Ole A. Andreassen, Danielle Posthuma, Jordi Clarimón, Mercè Boada, Wiesje M. van der Flier, Alfredo Ramirez, Jean-Charles Lambert, Sven J. van der Lee, Agustín Ruiz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3baab8412752494a9ff0927d1cfb9b68
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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record_format	dspace
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Itziar de Rojas Sonia Moreno-Grau Niccolo Tesi Benjamin Grenier-Boley Victor Andrade Iris E. Jansen Nancy L. Pedersen Najada Stringa Anna Zettergren Isabel Hernández Laura Montrreal Carmen Antúnez Anna Antonell Rick M. Tankard Joshua C. Bis Rebecca Sims Céline Bellenguez Inés Quintela Antonio González-Perez Miguel Calero Emilio Franco-Macías Juan Macías Rafael Blesa Laura Cervera-Carles Manuel Menéndez-González Ana Frank-García Jose Luís Royo Fermin Moreno Raquel Huerto Vilas Miquel Baquero Mónica Diez-Fairen Carmen Lage Sebastián García-Madrona Pablo García-González Emilio Alarcón-Martín Sergi Valero Oscar Sotolongo-Grau Abbe Ullgren Adam C. Naj Afina W. Lemstra Alba Benaque Alba Pérez-Cordón Alberto Benussi Alberto Rábano Alessandro Padovani Alessio Squassina Alexandre de Mendonça Alfonso Arias Pastor Almar A. L. Kok Alun Meggy Ana Belén Pastor Ana Espinosa Anaïs Corma-Gómez Angel Martín Montes Ángela Sanabria Anita L. DeStefano Anja Schneider Annakaisa Haapasalo Anne Kinhult Ståhlbom Anne Tybjærg-Hansen Annette M. Hartmann Annika Spottke Arturo Corbatón-Anchuelo Arvid Rongve Barbara Borroni Beatrice Arosio Benedetta Nacmias Børge G. Nordestgaard Brian W. Kunkle Camille Charbonnier Carla Abdelnour Carlo Masullo Carmen Martínez Rodríguez Carmen Muñoz-Fernandez Carole Dufouil Caroline Graff Catarina B. Ferreira Caterina Chillotti Chandra A. Reynolds Chiara Fenoglio Christine Van Broeckhoven Christopher Clark Claudia Pisanu Claudia L. Satizabal Clive Holmes Dolores Buiza-Rueda Dag Aarsland Dan Rujescu Daniel Alcolea Daniela Galimberti David Wallon Davide Seripa Edna Grünblatt Efthimios Dardiotis Emrah Düzel Elio Scarpini Elisa Conti Elisa Rubino Ellen Gelpi Eloy Rodriguez-Rodriguez Emmanuelle Duron Eric Boerwinkle Evelyn Ferri Fabrizio Tagliavini Fahri Küçükali Florence Pasquier Florentino Sanchez-Garcia Francesca Mangialasche Frank Jessen Gaël Nicolas Geir Selbæk Gemma Ortega Geneviève Chêne Georgios Hadjigeorgiou Giacomina Rossi Gianfranco Spalletta Giorgio Giaccone Giulia Grande Giuliano Binetti Goran Papenberg Harald Hampel Henri Bailly Henrik Zetterberg Hilkka Soininen Ida K. Karlsson Ignacio Alvarez Ildebrando Appollonio Ina Giegling Ingmar Skoog Ingvild Saltvedt Innocenzo Rainero Irene Rosas Allende Jakub Hort Janine Diehl-Schmid Jasper Van Dongen Jean-Sebastien Vidal Jenni Lehtisalo Jens Wiltfang Jesper Qvist Thomassen Johannes Kornhuber Jonathan L. Haines Jonathan Vogelgsang Juan A. Pineda Juan Fortea Julius Popp Jürgen Deckert Katharina Buerger Kevin Morgan Klaus Fließbach Kristel Sleegers Laura Molina-Porcel Lena Kilander Leonie Weinhold Lindsay A. Farrer Li-San Wang Luca Kleineidam Lucia Farotti Lucilla Parnetti Lucio Tremolizzo Lucrezia Hausner Luisa Benussi Lutz Froelich M. Arfan Ikram M. Candida Deniz-Naranjo Magda Tsolaki Maitée Rosende-Roca Malin Löwenmark Marc Hulsman Marco Spallazzi Margaret A. Pericak-Vance Margaret Esiri María Bernal Sánchez-Arjona Maria Carolina Dalmasso María Teresa Martínez-Larrad Marina Arcaro Markus M. Nöthen Marta Fernández-Fuertes Martin Dichgans Martin Ingelsson Martin J. Herrmann Martin Scherer Martin Vyhnalek Mary H. Kosmidis Mary Yannakoulia Matthias Schmid Michael Ewers Michael T. Heneka Michael Wagner Michela Scamosci Miia Kivipelto Mikko Hiltunen Miren Zulaica Montserrat Alegret Myriam Fornage Natalia Roberto Natasja M. van Schoor Nazib M. Seidu Nerisa Banaj Nicola J. Armstrong Nikolaos Scarmeas Norbert Scherbaum Oliver Goldhardt Oliver Hanon Oliver Peters Olivia Anna Skrobot Olivier Quenez Ondrej Lerch Paola Bossù Paolo Caffarra Paolo Dionigi Rossi Paraskevi Sakka Per Hoffmann Peter A. Holmans Peter Fischer Peter Riederer Qiong Yang Rachel Marshall Rajesh N. Kalaria Richard Mayeux Rik Vandenberghe Roberta Cecchetti Roberta Ghidoni Ruth Frikke-Schmidt Sandro Sorbi Sara Hägg Sebastiaan Engelborghs Seppo Helisalmi Sigrid Botne Sando Silke Kern Silvana Archetti Silvia Boschi Silvia Fostinelli Silvia Gil Silvia Mendoza Simon Mead Simona Ciccone Srdjan Djurovic Stefanie Heilmann-Heimbach Steffi Riedel-Heller Teemu Kuulasmaa Teodoro del Ser Thibaud Lebouvier Thomas Polak Tiia Ngandu Timo Grimmer Valentina Bessi Valentina Escott-Price Vilmantas Giedraitis Vincent Deramecourt Wolfgang Maier Xueqiu Jian Yolande A. L. Pijnenburg EADB contributors The GR@ACE study group DEGESCO consortium IGAP (ADGC, CHARGE, EADI, GERAD) PGC-ALZ consortia Patrick Gavin Kehoe Guillermo Garcia-Ribas Pascual Sánchez-Juan Pau Pastor Jordi Pérez-Tur Gerard Piñol-Ripoll Adolfo Lopez de Munain Jose María García-Alberca María J. Bullido Victoria Álvarez Alberto Lleó Luis M. Real Pablo Mir Miguel Medina Philip Scheltens Henne Holstege Marta Marquié María Eugenia Sáez Ángel Carracedo Philippe Amouyel Gerard D. Schellenberg Julie Williams Sudha Seshadri Cornelia M. van Duijn Karen A. Mather Raquel Sánchez-Valle Manuel Serrano-Ríos Adelina Orellana Lluís Tárraga Kaj Blennow Martijn Huisman Ole A. Andreassen Danielle Posthuma Jordi Clarimón Mercè Boada Wiesje M. van der Flier Alfredo Ramirez Jean-Charles Lambert Sven J. van der Lee Agustín Ruiz Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
description	Known genetic loci account for only a fraction of the genetic contribution to Alzheimer’s disease. Here, the authors have performed a large genome-wide meta-analysis comprising 409,435 individuals to discover 6 new loci and demonstrate the efficacy of an Alzheimer’s disease polygenic risk score.
format	article
author	Itziar de Rojas Sonia Moreno-Grau Niccolo Tesi Benjamin Grenier-Boley Victor Andrade Iris E. Jansen Nancy L. Pedersen Najada Stringa Anna Zettergren Isabel Hernández Laura Montrreal Carmen Antúnez Anna Antonell Rick M. Tankard Joshua C. Bis Rebecca Sims Céline Bellenguez Inés Quintela Antonio González-Perez Miguel Calero Emilio Franco-Macías Juan Macías Rafael Blesa Laura Cervera-Carles Manuel Menéndez-González Ana Frank-García Jose Luís Royo Fermin Moreno Raquel Huerto Vilas Miquel Baquero Mónica Diez-Fairen Carmen Lage Sebastián García-Madrona Pablo García-González Emilio Alarcón-Martín Sergi Valero Oscar Sotolongo-Grau Abbe Ullgren Adam C. Naj Afina W. Lemstra Alba Benaque Alba Pérez-Cordón Alberto Benussi Alberto Rábano Alessandro Padovani Alessio Squassina Alexandre de Mendonça Alfonso Arias Pastor Almar A. L. Kok Alun Meggy Ana Belén Pastor Ana Espinosa Anaïs Corma-Gómez Angel Martín Montes Ángela Sanabria Anita L. DeStefano Anja Schneider Annakaisa Haapasalo Anne Kinhult Ståhlbom Anne Tybjærg-Hansen Annette M. Hartmann Annika Spottke Arturo Corbatón-Anchuelo Arvid Rongve Barbara Borroni Beatrice Arosio Benedetta Nacmias Børge G. Nordestgaard Brian W. Kunkle Camille Charbonnier Carla Abdelnour Carlo Masullo Carmen Martínez Rodríguez Carmen Muñoz-Fernandez Carole Dufouil Caroline Graff Catarina B. Ferreira Caterina Chillotti Chandra A. Reynolds Chiara Fenoglio Christine Van Broeckhoven Christopher Clark Claudia Pisanu Claudia L. Satizabal Clive Holmes Dolores Buiza-Rueda Dag Aarsland Dan Rujescu Daniel Alcolea Daniela Galimberti David Wallon Davide Seripa Edna Grünblatt Efthimios Dardiotis Emrah Düzel Elio Scarpini Elisa Conti Elisa Rubino Ellen Gelpi Eloy Rodriguez-Rodriguez Emmanuelle Duron Eric Boerwinkle Evelyn Ferri Fabrizio Tagliavini Fahri Küçükali Florence Pasquier Florentino Sanchez-Garcia Francesca Mangialasche Frank Jessen Gaël Nicolas Geir Selbæk Gemma Ortega Geneviève Chêne Georgios Hadjigeorgiou Giacomina Rossi Gianfranco Spalletta Giorgio Giaccone Giulia Grande Giuliano Binetti Goran Papenberg Harald Hampel Henri Bailly Henrik Zetterberg Hilkka Soininen Ida K. Karlsson Ignacio Alvarez Ildebrando Appollonio Ina Giegling Ingmar Skoog Ingvild Saltvedt Innocenzo Rainero Irene Rosas Allende Jakub Hort Janine Diehl-Schmid Jasper Van Dongen Jean-Sebastien Vidal Jenni Lehtisalo Jens Wiltfang Jesper Qvist Thomassen Johannes Kornhuber Jonathan L. Haines Jonathan Vogelgsang Juan A. Pineda Juan Fortea Julius Popp Jürgen Deckert Katharina Buerger Kevin Morgan Klaus Fließbach Kristel Sleegers Laura Molina-Porcel Lena Kilander Leonie Weinhold Lindsay A. Farrer Li-San Wang Luca Kleineidam Lucia Farotti Lucilla Parnetti Lucio Tremolizzo Lucrezia Hausner Luisa Benussi Lutz Froelich M. Arfan Ikram M. Candida Deniz-Naranjo Magda Tsolaki Maitée Rosende-Roca Malin Löwenmark Marc Hulsman Marco Spallazzi Margaret A. Pericak-Vance Margaret Esiri María Bernal Sánchez-Arjona Maria Carolina Dalmasso María Teresa Martínez-Larrad Marina Arcaro Markus M. Nöthen Marta Fernández-Fuertes Martin Dichgans Martin Ingelsson Martin J. Herrmann Martin Scherer Martin Vyhnalek Mary H. Kosmidis Mary Yannakoulia Matthias Schmid Michael Ewers Michael T. Heneka Michael Wagner Michela Scamosci Miia Kivipelto Mikko Hiltunen Miren Zulaica Montserrat Alegret Myriam Fornage Natalia Roberto Natasja M. van Schoor Nazib M. Seidu Nerisa Banaj Nicola J. Armstrong Nikolaos Scarmeas Norbert Scherbaum Oliver Goldhardt Oliver Hanon Oliver Peters Olivia Anna Skrobot Olivier Quenez Ondrej Lerch Paola Bossù Paolo Caffarra Paolo Dionigi Rossi Paraskevi Sakka Per Hoffmann Peter A. Holmans Peter Fischer Peter Riederer Qiong Yang Rachel Marshall Rajesh N. Kalaria Richard Mayeux Rik Vandenberghe Roberta Cecchetti Roberta Ghidoni Ruth Frikke-Schmidt Sandro Sorbi Sara Hägg Sebastiaan Engelborghs Seppo Helisalmi Sigrid Botne Sando Silke Kern Silvana Archetti Silvia Boschi Silvia Fostinelli Silvia Gil Silvia Mendoza Simon Mead Simona Ciccone Srdjan Djurovic Stefanie Heilmann-Heimbach Steffi Riedel-Heller Teemu Kuulasmaa Teodoro del Ser Thibaud Lebouvier Thomas Polak Tiia Ngandu Timo Grimmer Valentina Bessi Valentina Escott-Price Vilmantas Giedraitis Vincent Deramecourt Wolfgang Maier Xueqiu Jian Yolande A. L. Pijnenburg EADB contributors The GR@ACE study group DEGESCO consortium IGAP (ADGC, CHARGE, EADI, GERAD) PGC-ALZ consortia Patrick Gavin Kehoe Guillermo Garcia-Ribas Pascual Sánchez-Juan Pau Pastor Jordi Pérez-Tur Gerard Piñol-Ripoll Adolfo Lopez de Munain Jose María García-Alberca María J. Bullido Victoria Álvarez Alberto Lleó Luis M. Real Pablo Mir Miguel Medina Philip Scheltens Henne Holstege Marta Marquié María Eugenia Sáez Ángel Carracedo Philippe Amouyel Gerard D. Schellenberg Julie Williams Sudha Seshadri Cornelia M. van Duijn Karen A. Mather Raquel Sánchez-Valle Manuel Serrano-Ríos Adelina Orellana Lluís Tárraga Kaj Blennow Martijn Huisman Ole A. Andreassen Danielle Posthuma Jordi Clarimón Mercè Boada Wiesje M. van der Flier Alfredo Ramirez Jean-Charles Lambert Sven J. van der Lee Agustín Ruiz
author_facet	Itziar de Rojas Sonia Moreno-Grau Niccolo Tesi Benjamin Grenier-Boley Victor Andrade Iris E. Jansen Nancy L. Pedersen Najada Stringa Anna Zettergren Isabel Hernández Laura Montrreal Carmen Antúnez Anna Antonell Rick M. Tankard Joshua C. Bis Rebecca Sims Céline Bellenguez Inés Quintela Antonio González-Perez Miguel Calero Emilio Franco-Macías Juan Macías Rafael Blesa Laura Cervera-Carles Manuel Menéndez-González Ana Frank-García Jose Luís Royo Fermin Moreno Raquel Huerto Vilas Miquel Baquero Mónica Diez-Fairen Carmen Lage Sebastián García-Madrona Pablo García-González Emilio Alarcón-Martín Sergi Valero Oscar Sotolongo-Grau Abbe Ullgren Adam C. Naj Afina W. Lemstra Alba Benaque Alba Pérez-Cordón Alberto Benussi Alberto Rábano Alessandro Padovani Alessio Squassina Alexandre de Mendonça Alfonso Arias Pastor Almar A. L. Kok Alun Meggy Ana Belén Pastor Ana Espinosa Anaïs Corma-Gómez Angel Martín Montes Ángela Sanabria Anita L. DeStefano Anja Schneider Annakaisa Haapasalo Anne Kinhult Ståhlbom Anne Tybjærg-Hansen Annette M. Hartmann Annika Spottke Arturo Corbatón-Anchuelo Arvid Rongve Barbara Borroni Beatrice Arosio Benedetta Nacmias Børge G. Nordestgaard Brian W. Kunkle Camille Charbonnier Carla Abdelnour Carlo Masullo Carmen Martínez Rodríguez Carmen Muñoz-Fernandez Carole Dufouil Caroline Graff Catarina B. Ferreira Caterina Chillotti Chandra A. Reynolds Chiara Fenoglio Christine Van Broeckhoven Christopher Clark Claudia Pisanu Claudia L. Satizabal Clive Holmes Dolores Buiza-Rueda Dag Aarsland Dan Rujescu Daniel Alcolea Daniela Galimberti David Wallon Davide Seripa Edna Grünblatt Efthimios Dardiotis Emrah Düzel Elio Scarpini Elisa Conti Elisa Rubino Ellen Gelpi Eloy Rodriguez-Rodriguez Emmanuelle Duron Eric Boerwinkle Evelyn Ferri Fabrizio Tagliavini Fahri Küçükali Florence Pasquier Florentino Sanchez-Garcia Francesca Mangialasche Frank Jessen Gaël Nicolas Geir Selbæk Gemma Ortega Geneviève Chêne Georgios Hadjigeorgiou Giacomina Rossi Gianfranco Spalletta Giorgio Giaccone Giulia Grande Giuliano Binetti Goran Papenberg Harald Hampel Henri Bailly Henrik Zetterberg Hilkka Soininen Ida K. Karlsson Ignacio Alvarez Ildebrando Appollonio Ina Giegling Ingmar Skoog Ingvild Saltvedt Innocenzo Rainero Irene Rosas Allende Jakub Hort Janine Diehl-Schmid Jasper Van Dongen Jean-Sebastien Vidal Jenni Lehtisalo Jens Wiltfang Jesper Qvist Thomassen Johannes Kornhuber Jonathan L. Haines Jonathan Vogelgsang Juan A. Pineda Juan Fortea Julius Popp Jürgen Deckert Katharina Buerger Kevin Morgan Klaus Fließbach Kristel Sleegers Laura Molina-Porcel Lena Kilander Leonie Weinhold Lindsay A. Farrer Li-San Wang Luca Kleineidam Lucia Farotti Lucilla Parnetti Lucio Tremolizzo Lucrezia Hausner Luisa Benussi Lutz Froelich M. Arfan Ikram M. Candida Deniz-Naranjo Magda Tsolaki Maitée Rosende-Roca Malin Löwenmark Marc Hulsman Marco Spallazzi Margaret A. Pericak-Vance Margaret Esiri María Bernal Sánchez-Arjona Maria Carolina Dalmasso María Teresa Martínez-Larrad Marina Arcaro Markus M. Nöthen Marta Fernández-Fuertes Martin Dichgans Martin Ingelsson Martin J. Herrmann Martin Scherer Martin Vyhnalek Mary H. Kosmidis Mary Yannakoulia Matthias Schmid Michael Ewers Michael T. Heneka Michael Wagner Michela Scamosci Miia Kivipelto Mikko Hiltunen Miren Zulaica Montserrat Alegret Myriam Fornage Natalia Roberto Natasja M. van Schoor Nazib M. Seidu Nerisa Banaj Nicola J. Armstrong Nikolaos Scarmeas Norbert Scherbaum Oliver Goldhardt Oliver Hanon Oliver Peters Olivia Anna Skrobot Olivier Quenez Ondrej Lerch Paola Bossù Paolo Caffarra Paolo Dionigi Rossi Paraskevi Sakka Per Hoffmann Peter A. Holmans Peter Fischer Peter Riederer Qiong Yang Rachel Marshall Rajesh N. Kalaria Richard Mayeux Rik Vandenberghe Roberta Cecchetti Roberta Ghidoni Ruth Frikke-Schmidt Sandro Sorbi Sara Hägg Sebastiaan Engelborghs Seppo Helisalmi Sigrid Botne Sando Silke Kern Silvana Archetti Silvia Boschi Silvia Fostinelli Silvia Gil Silvia Mendoza Simon Mead Simona Ciccone Srdjan Djurovic Stefanie Heilmann-Heimbach Steffi Riedel-Heller Teemu Kuulasmaa Teodoro del Ser Thibaud Lebouvier Thomas Polak Tiia Ngandu Timo Grimmer Valentina Bessi Valentina Escott-Price Vilmantas Giedraitis Vincent Deramecourt Wolfgang Maier Xueqiu Jian Yolande A. L. Pijnenburg EADB contributors The GR@ACE study group DEGESCO consortium IGAP (ADGC, CHARGE, EADI, GERAD) PGC-ALZ consortia Patrick Gavin Kehoe Guillermo Garcia-Ribas Pascual Sánchez-Juan Pau Pastor Jordi Pérez-Tur Gerard Piñol-Ripoll Adolfo Lopez de Munain Jose María García-Alberca María J. Bullido Victoria Álvarez Alberto Lleó Luis M. Real Pablo Mir Miguel Medina Philip Scheltens Henne Holstege Marta Marquié María Eugenia Sáez Ángel Carracedo Philippe Amouyel Gerard D. Schellenberg Julie Williams Sudha Seshadri Cornelia M. van Duijn Karen A. Mather Raquel Sánchez-Valle Manuel Serrano-Ríos Adelina Orellana Lluís Tárraga Kaj Blennow Martijn Huisman Ole A. Andreassen Danielle Posthuma Jordi Clarimón Mercè Boada Wiesje M. van der Flier Alfredo Ramirez Jean-Charles Lambert Sven J. van der Lee Agustín Ruiz
author_sort	Itziar de Rojas
title	Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
title_short	Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
title_full	Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
title_fullStr	Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
title_full_unstemmed	Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
title_sort	common variants in alzheimer’s disease and risk stratification by polygenic risk scores
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3baab8412752494a9ff0927d1cfb9b68
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spelling	oai:doaj.org-article:3baab8412752494a9ff0927d1cfb9b682021-12-02T17:34:38ZCommon variants in Alzheimer’s disease and risk stratification by polygenic risk scores10.1038/s41467-021-22491-82041-1723https://doaj.org/article/3baab8412752494a9ff0927d1cfb9b682021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22491-8https://doaj.org/toc/2041-1723Known genetic loci account for only a fraction of the genetic contribution to Alzheimer’s disease. Here, the authors have performed a large genome-wide meta-analysis comprising 409,435 individuals to discover 6 new loci and demonstrate the efficacy of an Alzheimer’s disease polygenic risk score.Itziar de RojasSonia Moreno-GrauNiccolo TesiBenjamin Grenier-BoleyVictor AndradeIris E. JansenNancy L. PedersenNajada StringaAnna ZettergrenIsabel HernándezLaura MontrrealCarmen AntúnezAnna AntonellRick M. TankardJoshua C. BisRebecca SimsCéline BellenguezInés QuintelaAntonio González-PerezMiguel CaleroEmilio Franco-MacíasJuan MacíasRafael BlesaLaura Cervera-CarlesManuel Menéndez-GonzálezAna Frank-GarcíaJose Luís RoyoFermin MorenoRaquel Huerto VilasMiquel BaqueroMónica Diez-FairenCarmen LageSebastián García-MadronaPablo García-GonzálezEmilio Alarcón-MartínSergi ValeroOscar Sotolongo-GrauAbbe UllgrenAdam C. NajAfina W. LemstraAlba BenaqueAlba Pérez-CordónAlberto BenussiAlberto RábanoAlessandro PadovaniAlessio SquassinaAlexandre de MendonçaAlfonso Arias PastorAlmar A. L. KokAlun MeggyAna Belén PastorAna EspinosaAnaïs Corma-GómezAngel Martín MontesÁngela SanabriaAnita L. DeStefanoAnja SchneiderAnnakaisa HaapasaloAnne Kinhult StåhlbomAnne Tybjærg-HansenAnnette M. HartmannAnnika SpottkeArturo Corbatón-AnchueloArvid RongveBarbara BorroniBeatrice ArosioBenedetta NacmiasBørge G. NordestgaardBrian W. KunkleCamille CharbonnierCarla AbdelnourCarlo MasulloCarmen Martínez RodríguezCarmen Muñoz-FernandezCarole DufouilCaroline GraffCatarina B. FerreiraCaterina ChillottiChandra A. ReynoldsChiara FenoglioChristine Van BroeckhovenChristopher ClarkClaudia PisanuClaudia L. SatizabalClive HolmesDolores Buiza-RuedaDag AarslandDan RujescuDaniel AlcoleaDaniela GalimbertiDavid WallonDavide SeripaEdna GrünblattEfthimios DardiotisEmrah DüzelElio ScarpiniElisa ContiElisa RubinoEllen GelpiEloy Rodriguez-RodriguezEmmanuelle DuronEric BoerwinkleEvelyn FerriFabrizio TagliaviniFahri KüçükaliFlorence PasquierFlorentino Sanchez-GarciaFrancesca MangialascheFrank JessenGaël NicolasGeir SelbækGemma OrtegaGeneviève ChêneGeorgios HadjigeorgiouGiacomina RossiGianfranco SpallettaGiorgio GiacconeGiulia GrandeGiuliano BinettiGoran PapenbergHarald HampelHenri BaillyHenrik ZetterbergHilkka SoininenIda K. KarlssonIgnacio AlvarezIldebrando AppollonioIna GieglingIngmar SkoogIngvild SaltvedtInnocenzo RaineroIrene Rosas AllendeJakub HortJanine Diehl-SchmidJasper Van DongenJean-Sebastien VidalJenni LehtisaloJens WiltfangJesper Qvist ThomassenJohannes KornhuberJonathan L. HainesJonathan VogelgsangJuan A. PinedaJuan ForteaJulius PoppJürgen DeckertKatharina BuergerKevin MorganKlaus FließbachKristel SleegersLaura Molina-PorcelLena KilanderLeonie WeinholdLindsay A. FarrerLi-San WangLuca KleineidamLucia FarottiLucilla ParnettiLucio TremolizzoLucrezia HausnerLuisa BenussiLutz FroelichM. Arfan IkramM. Candida Deniz-NaranjoMagda TsolakiMaitée Rosende-RocaMalin LöwenmarkMarc HulsmanMarco SpallazziMargaret A. Pericak-VanceMargaret EsiriMaría Bernal Sánchez-ArjonaMaria Carolina DalmassoMaría Teresa Martínez-LarradMarina ArcaroMarkus M. NöthenMarta Fernández-FuertesMartin DichgansMartin IngelssonMartin J. HerrmannMartin SchererMartin VyhnalekMary H. KosmidisMary YannakouliaMatthias SchmidMichael EwersMichael T. HenekaMichael WagnerMichela ScamosciMiia KivipeltoMikko HiltunenMiren ZulaicaMontserrat AlegretMyriam FornageNatalia RobertoNatasja M. van SchoorNazib M. SeiduNerisa BanajNicola J. ArmstrongNikolaos ScarmeasNorbert ScherbaumOliver GoldhardtOliver HanonOliver PetersOlivia Anna SkrobotOlivier QuenezOndrej LerchPaola BossùPaolo CaffarraPaolo Dionigi RossiParaskevi SakkaPer HoffmannPeter A. HolmansPeter FischerPeter RiedererQiong YangRachel MarshallRajesh N. KalariaRichard MayeuxRik VandenbergheRoberta CecchettiRoberta GhidoniRuth Frikke-SchmidtSandro SorbiSara HäggSebastiaan EngelborghsSeppo HelisalmiSigrid Botne SandoSilke KernSilvana ArchettiSilvia BoschiSilvia FostinelliSilvia GilSilvia MendozaSimon MeadSimona CicconeSrdjan DjurovicStefanie Heilmann-HeimbachSteffi Riedel-HellerTeemu KuulasmaaTeodoro del SerThibaud LebouvierThomas PolakTiia NganduTimo GrimmerValentina BessiValentina Escott-PriceVilmantas GiedraitisVincent DeramecourtWolfgang MaierXueqiu JianYolande A. L. PijnenburgEADB contributorsThe GR@ACE study groupDEGESCO consortiumIGAP (ADGC, CHARGE, EADI, GERAD)PGC-ALZ consortiaPatrick Gavin KehoeGuillermo Garcia-RibasPascual Sánchez-JuanPau PastorJordi Pérez-TurGerard Piñol-RipollAdolfo Lopez de MunainJose María García-AlbercaMaría J. BullidoVictoria ÁlvarezAlberto LleóLuis M. RealPablo MirMiguel MedinaPhilip ScheltensHenne HolstegeMarta MarquiéMaría Eugenia SáezÁngel CarracedoPhilippe AmouyelGerard D. SchellenbergJulie WilliamsSudha SeshadriCornelia M. van DuijnKaren A. MatherRaquel Sánchez-ValleManuel Serrano-RíosAdelina OrellanaLluís TárragaKaj BlennowMartijn HuismanOle A. AndreassenDanielle PosthumaJordi ClarimónMercè BoadaWiesje M. van der FlierAlfredo RamirezJean-Charles LambertSven J. van der LeeAgustín RuizNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

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