Real-time tracking reveals catalytic roles for the two DNA binding sites of Rad51

Rad51 drives DNA strand exchange, the central reaction in recombinational DNA repair. Two sites of Rad51 are responsible for DNA binding, but the function of these sites has proven elusive. Here, the authors employ real-time assays to reveal catalytic roles for the two DNA binding sites of Rad51.

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Bibliographic Details
Main Authors:	Kentaro Ito, Yasuto Murayama, Yumiko Kurokawa, Shuji Kanamaru, Yuichi Kokabu, Takahisa Maki, Tsutomu Mikawa, Bilge Argunhan, Hideo Tsubouchi, Mitsunori Ikeguchi, Masayuki Takahashi, Hiroshi Iwasaki
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/3badcf720b9b4f14b822be0b8ba4eec2
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spelling	oai:doaj.org-article:3badcf720b9b4f14b822be0b8ba4eec22021-12-02T17:47:22ZReal-time tracking reveals catalytic roles for the two DNA binding sites of Rad5110.1038/s41467-020-16750-32041-1723https://doaj.org/article/3badcf720b9b4f14b822be0b8ba4eec22020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16750-3https://doaj.org/toc/2041-1723Rad51 drives DNA strand exchange, the central reaction in recombinational DNA repair. Two sites of Rad51 are responsible for DNA binding, but the function of these sites has proven elusive. Here, the authors employ real-time assays to reveal catalytic roles for the two DNA binding sites of Rad51.Kentaro ItoYasuto MurayamaYumiko KurokawaShuji KanamaruYuichi KokabuTakahisa MakiTsutomu MikawaBilge ArgunhanHideo TsubouchiMitsunori IkeguchiMasayuki TakahashiHiroshi IwasakiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kentaro Ito Yasuto Murayama Yumiko Kurokawa Shuji Kanamaru Yuichi Kokabu Takahisa Maki Tsutomu Mikawa Bilge Argunhan Hideo Tsubouchi Mitsunori Ikeguchi Masayuki Takahashi Hiroshi Iwasaki Real-time tracking reveals catalytic roles for the two DNA binding sites of Rad51
description	Rad51 drives DNA strand exchange, the central reaction in recombinational DNA repair. Two sites of Rad51 are responsible for DNA binding, but the function of these sites has proven elusive. Here, the authors employ real-time assays to reveal catalytic roles for the two DNA binding sites of Rad51.
format	article
author	Kentaro Ito Yasuto Murayama Yumiko Kurokawa Shuji Kanamaru Yuichi Kokabu Takahisa Maki Tsutomu Mikawa Bilge Argunhan Hideo Tsubouchi Mitsunori Ikeguchi Masayuki Takahashi Hiroshi Iwasaki
author_facet	Kentaro Ito Yasuto Murayama Yumiko Kurokawa Shuji Kanamaru Yuichi Kokabu Takahisa Maki Tsutomu Mikawa Bilge Argunhan Hideo Tsubouchi Mitsunori Ikeguchi Masayuki Takahashi Hiroshi Iwasaki
author_sort	Kentaro Ito
title	Real-time tracking reveals catalytic roles for the two DNA binding sites of Rad51
title_short	Real-time tracking reveals catalytic roles for the two DNA binding sites of Rad51
title_full	Real-time tracking reveals catalytic roles for the two DNA binding sites of Rad51
title_fullStr	Real-time tracking reveals catalytic roles for the two DNA binding sites of Rad51
title_full_unstemmed	Real-time tracking reveals catalytic roles for the two DNA binding sites of Rad51
title_sort	real-time tracking reveals catalytic roles for the two dna binding sites of rad51
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3badcf720b9b4f14b822be0b8ba4eec2
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Real-time tracking reveals catalytic roles for the two DNA binding sites of Rad51

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