Pineal-dependent increase of hypothalamic neurogenesis contributes to the timing of seasonal reproduction in sheep

Abstract To survive in temperate latitudes, species rely on the photoperiod to synchronize their physiological functions, including reproduction, with the predictable changes in the environment. In sheep, exposure to decreasing day length reactivates the hypothalamo-pituitary-gonadal axis, while dur...

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Autores principales:	Martine Batailler, Didier Chesneau, Laura Derouet, Lucile Butruille, Stéphanie Segura, Juliette Cognié, Joëlle Dupont, Delphine Pillon, Martine Migaud
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3bafb7f9ff4c460d91667636ea6d95c1
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spelling	oai:doaj.org-article:3bafb7f9ff4c460d91667636ea6d95c12021-12-02T15:08:05ZPineal-dependent increase of hypothalamic neurogenesis contributes to the timing of seasonal reproduction in sheep10.1038/s41598-018-24381-42045-2322https://doaj.org/article/3bafb7f9ff4c460d91667636ea6d95c12018-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-24381-4https://doaj.org/toc/2045-2322Abstract To survive in temperate latitudes, species rely on the photoperiod to synchronize their physiological functions, including reproduction, with the predictable changes in the environment. In sheep, exposure to decreasing day length reactivates the hypothalamo-pituitary-gonadal axis, while during increasing day length, animals enter a period of sexual rest. Neural stem cells have been detected in the sheep hypothalamus and hypothalamic neurogenesis was found to respond to the photoperiod. However, the physiological relevance of this seasonal adult neurogenesis is still unexplored. This longitudinal study, therefore aimed to thoroughly characterize photoperiod-stimulated neurogenesis and to investigate whether the hypothalamic adult born-cells were involved in the seasonal timing of reproduction. Results showed that time course of cell proliferation reached a peak in the middle of the period of sexual activity, corresponding to decreasing day length period. This enhancement was suppressed when animals were deprived of seasonal time cues by pinealectomy, suggesting a role of melatonin in the seasonal regulation of cell proliferation. Furthermore, when the mitotic blocker cytosine-b-D-arabinofuranoside was administered centrally, the timing of seasonal reproduction was affected. Overall, our findings link the cyclic increase in hypothalamic neurogenesis to seasonal reproduction and suggest that photoperiod-regulated hypothalamic neurogenesis plays a substantial role in seasonal reproductive physiology.Martine BataillerDidier ChesneauLaura DerouetLucile ButruilleStéphanie SeguraJuliette CogniéJoëlle DupontDelphine PillonMartine MigaudNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Martine Batailler Didier Chesneau Laura Derouet Lucile Butruille Stéphanie Segura Juliette Cognié Joëlle Dupont Delphine Pillon Martine Migaud Pineal-dependent increase of hypothalamic neurogenesis contributes to the timing of seasonal reproduction in sheep
description	Abstract To survive in temperate latitudes, species rely on the photoperiod to synchronize their physiological functions, including reproduction, with the predictable changes in the environment. In sheep, exposure to decreasing day length reactivates the hypothalamo-pituitary-gonadal axis, while during increasing day length, animals enter a period of sexual rest. Neural stem cells have been detected in the sheep hypothalamus and hypothalamic neurogenesis was found to respond to the photoperiod. However, the physiological relevance of this seasonal adult neurogenesis is still unexplored. This longitudinal study, therefore aimed to thoroughly characterize photoperiod-stimulated neurogenesis and to investigate whether the hypothalamic adult born-cells were involved in the seasonal timing of reproduction. Results showed that time course of cell proliferation reached a peak in the middle of the period of sexual activity, corresponding to decreasing day length period. This enhancement was suppressed when animals were deprived of seasonal time cues by pinealectomy, suggesting a role of melatonin in the seasonal regulation of cell proliferation. Furthermore, when the mitotic blocker cytosine-b-D-arabinofuranoside was administered centrally, the timing of seasonal reproduction was affected. Overall, our findings link the cyclic increase in hypothalamic neurogenesis to seasonal reproduction and suggest that photoperiod-regulated hypothalamic neurogenesis plays a substantial role in seasonal reproductive physiology.
format	article
author	Martine Batailler Didier Chesneau Laura Derouet Lucile Butruille Stéphanie Segura Juliette Cognié Joëlle Dupont Delphine Pillon Martine Migaud
author_facet	Martine Batailler Didier Chesneau Laura Derouet Lucile Butruille Stéphanie Segura Juliette Cognié Joëlle Dupont Delphine Pillon Martine Migaud
author_sort	Martine Batailler
title	Pineal-dependent increase of hypothalamic neurogenesis contributes to the timing of seasonal reproduction in sheep
title_short	Pineal-dependent increase of hypothalamic neurogenesis contributes to the timing of seasonal reproduction in sheep
title_full	Pineal-dependent increase of hypothalamic neurogenesis contributes to the timing of seasonal reproduction in sheep
title_fullStr	Pineal-dependent increase of hypothalamic neurogenesis contributes to the timing of seasonal reproduction in sheep
title_full_unstemmed	Pineal-dependent increase of hypothalamic neurogenesis contributes to the timing of seasonal reproduction in sheep
title_sort	pineal-dependent increase of hypothalamic neurogenesis contributes to the timing of seasonal reproduction in sheep
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3bafb7f9ff4c460d91667636ea6d95c1
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Pineal-dependent increase of hypothalamic neurogenesis contributes to the timing of seasonal reproduction in sheep

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