AD Course Map charts Alzheimer’s disease progression

AD Course Map charts Alzheimer’s disease progression

Abstract Alzheimer’s disease (AD) is characterized by the progressive alterations seen in brain images which give rise to the onset of various sets of symptoms. The variability in the dynamics of changes in both brain images and cognitive impairments remains poorly understood. This paper introduces...

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Autores principales: Igor Koval, Alexandre Bône, Maxime Louis, Thomas Lartigue, Simona Bottani, Arnaud Marcoux, Jorge Samper-González, Ninon Burgos, Benjamin Charlier, Anne Bertrand, Stéphane Epelbaum, Olivier Colliot, Stéphanie Allassonnière, Stanley Durrleman
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/3bb22a9b97884f2c9673b8a79351bb74
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spelling oai:doaj.org-article:3bb22a9b97884f2c9673b8a79351bb742021-12-02T14:30:52ZAD Course Map charts Alzheimer’s disease progression10.1038/s41598-021-87434-12045-2322https://doaj.org/article/3bb22a9b97884f2c9673b8a79351bb742021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87434-1https://doaj.org/toc/2045-2322Abstract Alzheimer’s disease (AD) is characterized by the progressive alterations seen in brain images which give rise to the onset of various sets of symptoms. The variability in the dynamics of changes in both brain images and cognitive impairments remains poorly understood. This paper introduces AD Course Map a spatiotemporal atlas of Alzheimer’s disease progression. It summarizes the variability in the progression of a series of neuropsychological assessments, the propagation of hypometabolism and cortical thinning across brain regions and the deformation of the shape of the hippocampus. The analysis of these variations highlights strong genetic determinants for the progression, like possible compensatory mechanisms at play during disease progression. AD Course Map also predicts the patient’s cognitive decline with a better accuracy than the 56 methods benchmarked in the open challenge TADPOLE. Finally, AD Course Map is used to simulate cohorts of virtual patients developing Alzheimer’s disease. AD Course Map offers therefore new tools for exploring the progression of AD and personalizing patients care.Igor KovalAlexandre BôneMaxime LouisThomas LartigueSimona BottaniArnaud MarcouxJorge Samper-GonzálezNinon BurgosBenjamin CharlierAnne BertrandStéphane EpelbaumOlivier ColliotStéphanie AllassonnièreStanley DurrlemanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Igor Koval
Alexandre Bône
Maxime Louis
Thomas Lartigue
Simona Bottani
Arnaud Marcoux
Jorge Samper-González
Ninon Burgos
Benjamin Charlier
Anne Bertrand
Stéphane Epelbaum
Olivier Colliot
Stéphanie Allassonnière
Stanley Durrleman
AD Course Map charts Alzheimer’s disease progression
description Abstract Alzheimer’s disease (AD) is characterized by the progressive alterations seen in brain images which give rise to the onset of various sets of symptoms. The variability in the dynamics of changes in both brain images and cognitive impairments remains poorly understood. This paper introduces AD Course Map a spatiotemporal atlas of Alzheimer’s disease progression. It summarizes the variability in the progression of a series of neuropsychological assessments, the propagation of hypometabolism and cortical thinning across brain regions and the deformation of the shape of the hippocampus. The analysis of these variations highlights strong genetic determinants for the progression, like possible compensatory mechanisms at play during disease progression. AD Course Map also predicts the patient’s cognitive decline with a better accuracy than the 56 methods benchmarked in the open challenge TADPOLE. Finally, AD Course Map is used to simulate cohorts of virtual patients developing Alzheimer’s disease. AD Course Map offers therefore new tools for exploring the progression of AD and personalizing patients care.
format article
author Igor Koval
Alexandre Bône
Maxime Louis
Thomas Lartigue
Simona Bottani
Arnaud Marcoux
Jorge Samper-González
Ninon Burgos
Benjamin Charlier
Anne Bertrand
Stéphane Epelbaum
Olivier Colliot
Stéphanie Allassonnière
Stanley Durrleman
author_facet Igor Koval
Alexandre Bône
Maxime Louis
Thomas Lartigue
Simona Bottani
Arnaud Marcoux
Jorge Samper-González
Ninon Burgos
Benjamin Charlier
Anne Bertrand
Stéphane Epelbaum
Olivier Colliot
Stéphanie Allassonnière
Stanley Durrleman
author_sort Igor Koval
title AD Course Map charts Alzheimer’s disease progression
title_short AD Course Map charts Alzheimer’s disease progression
title_full AD Course Map charts Alzheimer’s disease progression
title_fullStr AD Course Map charts Alzheimer’s disease progression
title_full_unstemmed AD Course Map charts Alzheimer’s disease progression
title_sort ad course map charts alzheimer’s disease progression
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/3bb22a9b97884f2c9673b8a79351bb74
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