Lateral inhibition by Martinotti interneurons is facilitated by cholinergic inputs in human and mouse neocortex

Parvalbumin and somatostatin expressing interneurons mediate lateral inhibition between cortical neurons. Here the authors report the mechanisms by which acetylcholine from the basal forebrain selectively augments lateral inhibition via Martinotti cells and show that this is conserved in humans.

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Autores principales: Joshua Obermayer, Tim S. Heistek, Amber Kerkhofs, Natalia A. Goriounova, Tim Kroon, Johannes C. Baayen, Sander Idema, Guilherme Testa-Silva, Jonathan J. Couey, Huibert D. Mansvelder
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Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/3bb32f558e4e41c8984accb0680d2e97
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spelling oai:doaj.org-article:3bb32f558e4e41c8984accb0680d2e972021-12-02T14:40:06ZLateral inhibition by Martinotti interneurons is facilitated by cholinergic inputs in human and mouse neocortex10.1038/s41467-018-06628-w2041-1723https://doaj.org/article/3bb32f558e4e41c8984accb0680d2e972018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06628-whttps://doaj.org/toc/2041-1723Parvalbumin and somatostatin expressing interneurons mediate lateral inhibition between cortical neurons. Here the authors report the mechanisms by which acetylcholine from the basal forebrain selectively augments lateral inhibition via Martinotti cells and show that this is conserved in humans.Joshua ObermayerTim S. HeistekAmber KerkhofsNatalia A. GoriounovaTim KroonJohannes C. BaayenSander IdemaGuilherme Testa-SilvaJonathan J. CoueyHuibert D. MansvelderNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Joshua Obermayer
Tim S. Heistek
Amber Kerkhofs
Natalia A. Goriounova
Tim Kroon
Johannes C. Baayen
Sander Idema
Guilherme Testa-Silva
Jonathan J. Couey
Huibert D. Mansvelder
Lateral inhibition by Martinotti interneurons is facilitated by cholinergic inputs in human and mouse neocortex
description Parvalbumin and somatostatin expressing interneurons mediate lateral inhibition between cortical neurons. Here the authors report the mechanisms by which acetylcholine from the basal forebrain selectively augments lateral inhibition via Martinotti cells and show that this is conserved in humans.
format article
author Joshua Obermayer
Tim S. Heistek
Amber Kerkhofs
Natalia A. Goriounova
Tim Kroon
Johannes C. Baayen
Sander Idema
Guilherme Testa-Silva
Jonathan J. Couey
Huibert D. Mansvelder
author_facet Joshua Obermayer
Tim S. Heistek
Amber Kerkhofs
Natalia A. Goriounova
Tim Kroon
Johannes C. Baayen
Sander Idema
Guilherme Testa-Silva
Jonathan J. Couey
Huibert D. Mansvelder
author_sort Joshua Obermayer
title Lateral inhibition by Martinotti interneurons is facilitated by cholinergic inputs in human and mouse neocortex
title_short Lateral inhibition by Martinotti interneurons is facilitated by cholinergic inputs in human and mouse neocortex
title_full Lateral inhibition by Martinotti interneurons is facilitated by cholinergic inputs in human and mouse neocortex
title_fullStr Lateral inhibition by Martinotti interneurons is facilitated by cholinergic inputs in human and mouse neocortex
title_full_unstemmed Lateral inhibition by Martinotti interneurons is facilitated by cholinergic inputs in human and mouse neocortex
title_sort lateral inhibition by martinotti interneurons is facilitated by cholinergic inputs in human and mouse neocortex
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/3bb32f558e4e41c8984accb0680d2e97
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