Lateral inhibition by Martinotti interneurons is facilitated by cholinergic inputs in human and mouse neocortex
Parvalbumin and somatostatin expressing interneurons mediate lateral inhibition between cortical neurons. Here the authors report the mechanisms by which acetylcholine from the basal forebrain selectively augments lateral inhibition via Martinotti cells and show that this is conserved in humans.
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Nature Portfolio
2018
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oai:doaj.org-article:3bb32f558e4e41c8984accb0680d2e972021-12-02T14:40:06ZLateral inhibition by Martinotti interneurons is facilitated by cholinergic inputs in human and mouse neocortex10.1038/s41467-018-06628-w2041-1723https://doaj.org/article/3bb32f558e4e41c8984accb0680d2e972018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06628-whttps://doaj.org/toc/2041-1723Parvalbumin and somatostatin expressing interneurons mediate lateral inhibition between cortical neurons. Here the authors report the mechanisms by which acetylcholine from the basal forebrain selectively augments lateral inhibition via Martinotti cells and show that this is conserved in humans.Joshua ObermayerTim S. HeistekAmber KerkhofsNatalia A. GoriounovaTim KroonJohannes C. BaayenSander IdemaGuilherme Testa-SilvaJonathan J. CoueyHuibert D. MansvelderNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018) |
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Science Q Joshua Obermayer Tim S. Heistek Amber Kerkhofs Natalia A. Goriounova Tim Kroon Johannes C. Baayen Sander Idema Guilherme Testa-Silva Jonathan J. Couey Huibert D. Mansvelder Lateral inhibition by Martinotti interneurons is facilitated by cholinergic inputs in human and mouse neocortex |
description |
Parvalbumin and somatostatin expressing interneurons mediate lateral inhibition between cortical neurons. Here the authors report the mechanisms by which acetylcholine from the basal forebrain selectively augments lateral inhibition via Martinotti cells and show that this is conserved in humans. |
format |
article |
author |
Joshua Obermayer Tim S. Heistek Amber Kerkhofs Natalia A. Goriounova Tim Kroon Johannes C. Baayen Sander Idema Guilherme Testa-Silva Jonathan J. Couey Huibert D. Mansvelder |
author_facet |
Joshua Obermayer Tim S. Heistek Amber Kerkhofs Natalia A. Goriounova Tim Kroon Johannes C. Baayen Sander Idema Guilherme Testa-Silva Jonathan J. Couey Huibert D. Mansvelder |
author_sort |
Joshua Obermayer |
title |
Lateral inhibition by Martinotti interneurons is facilitated by cholinergic inputs in human and mouse neocortex |
title_short |
Lateral inhibition by Martinotti interneurons is facilitated by cholinergic inputs in human and mouse neocortex |
title_full |
Lateral inhibition by Martinotti interneurons is facilitated by cholinergic inputs in human and mouse neocortex |
title_fullStr |
Lateral inhibition by Martinotti interneurons is facilitated by cholinergic inputs in human and mouse neocortex |
title_full_unstemmed |
Lateral inhibition by Martinotti interneurons is facilitated by cholinergic inputs in human and mouse neocortex |
title_sort |
lateral inhibition by martinotti interneurons is facilitated by cholinergic inputs in human and mouse neocortex |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/3bb32f558e4e41c8984accb0680d2e97 |
work_keys_str_mv |
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1718390409258860544 |