A computational approach for identifying the chemical factors involved in the glycosaminoglycans-mediated acceleration of amyloid fibril formation.

<h4>Background</h4>Amyloid fibril formation is the hallmark of many human diseases, including Alzheimer's disease, type II diabetes and amyloidosis. Amyloid fibrils deposit in the extracellular space and generally co-localize with the glycosaminoglycans (GAGs) of the basement membra...

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Autores principales: Elodie Monsellier, Matteo Ramazzotti, Niccolò Taddei, Fabrizio Chiti
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2010
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Acceso en línea:https://doaj.org/article/3bb64fc85d6b4834a1577cb347d59b35
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