Applicability of optical coherence tomography angiography (OCTA) imaging in Parkinson’s disease

Abstract To evaluate the significance of motion artifacts in optical coherence tomography angiography (OCTA) images of patients with Parkinson’s disease (PD) and healthy controls. In this prospective, cross-sectional study subjects with medicated PD (ON) and healthy, age- and gender-matched voluntee...

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Autores principales:	Jost L. Lauermann, Jan A. M. Sochurek, Pauline Plöttner, Florian Alten, Meike Kasten, Jannik Prasuhn, Norbert Brüggemann, Mahdy Ranjbar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3bb72ab072714c29bcd2a79274e2097c
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spelling	oai:doaj.org-article:3bb72ab072714c29bcd2a79274e2097c2021-12-02T13:19:22ZApplicability of optical coherence tomography angiography (OCTA) imaging in Parkinson’s disease10.1038/s41598-021-84862-x2045-2322https://doaj.org/article/3bb72ab072714c29bcd2a79274e2097c2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84862-xhttps://doaj.org/toc/2045-2322Abstract To evaluate the significance of motion artifacts in optical coherence tomography angiography (OCTA) images of patients with Parkinson’s disease (PD) and healthy controls. In this prospective, cross-sectional study subjects with medicated PD (ON) and healthy, age- and gender-matched volunteers were recruited. Participants underwent specific ophthalmological examinations, including OCTA. Angiograms of the superficial retinal capillary plexus were evaluated for the type and frequency of artifacts using a validated motion artifact score (MAS). A total of 30 PD patients (60 eyes), average disease duration of 9.61 ± 5.55 years, and 30 matched, healthy controls (60 eyes) were recruited. Twenty percent of all eyes had an eye disease, unknown to the participant, with a significant impact on OCTA results. After cleansing the dataset by excluding subjects with confounding ocular comorbidities 42 eyes of 28 PD patients and 53 eyes of 29 healthy controls were further evaluated. Overall MAS and all five subtypes of motion artifacts were comparable without significant differences between groups. OCTA can be used in treated PD patients (ON) without a significant increase in motion artifacts. Nevertheless, special attention should be paid to image quality during the acquisition of OCTA data, for which an experienced OCTA operator is useful.Jost L. LauermannJan A. M. SochurekPauline PlöttnerFlorian AltenMeike KastenJannik PrasuhnNorbert BrüggemannMahdy RanjbarNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jost L. Lauermann Jan A. M. Sochurek Pauline Plöttner Florian Alten Meike Kasten Jannik Prasuhn Norbert Brüggemann Mahdy Ranjbar Applicability of optical coherence tomography angiography (OCTA) imaging in Parkinson’s disease
description	Abstract To evaluate the significance of motion artifacts in optical coherence tomography angiography (OCTA) images of patients with Parkinson’s disease (PD) and healthy controls. In this prospective, cross-sectional study subjects with medicated PD (ON) and healthy, age- and gender-matched volunteers were recruited. Participants underwent specific ophthalmological examinations, including OCTA. Angiograms of the superficial retinal capillary plexus were evaluated for the type and frequency of artifacts using a validated motion artifact score (MAS). A total of 30 PD patients (60 eyes), average disease duration of 9.61 ± 5.55 years, and 30 matched, healthy controls (60 eyes) were recruited. Twenty percent of all eyes had an eye disease, unknown to the participant, with a significant impact on OCTA results. After cleansing the dataset by excluding subjects with confounding ocular comorbidities 42 eyes of 28 PD patients and 53 eyes of 29 healthy controls were further evaluated. Overall MAS and all five subtypes of motion artifacts were comparable without significant differences between groups. OCTA can be used in treated PD patients (ON) without a significant increase in motion artifacts. Nevertheless, special attention should be paid to image quality during the acquisition of OCTA data, for which an experienced OCTA operator is useful.
format	article
author	Jost L. Lauermann Jan A. M. Sochurek Pauline Plöttner Florian Alten Meike Kasten Jannik Prasuhn Norbert Brüggemann Mahdy Ranjbar
author_facet	Jost L. Lauermann Jan A. M. Sochurek Pauline Plöttner Florian Alten Meike Kasten Jannik Prasuhn Norbert Brüggemann Mahdy Ranjbar
author_sort	Jost L. Lauermann
title	Applicability of optical coherence tomography angiography (OCTA) imaging in Parkinson’s disease
title_short	Applicability of optical coherence tomography angiography (OCTA) imaging in Parkinson’s disease
title_full	Applicability of optical coherence tomography angiography (OCTA) imaging in Parkinson’s disease
title_fullStr	Applicability of optical coherence tomography angiography (OCTA) imaging in Parkinson’s disease
title_full_unstemmed	Applicability of optical coherence tomography angiography (OCTA) imaging in Parkinson’s disease
title_sort	applicability of optical coherence tomography angiography (octa) imaging in parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3bb72ab072714c29bcd2a79274e2097c
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Applicability of optical coherence tomography angiography (OCTA) imaging in Parkinson’s disease

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