TYPE 2 DIABETES MELLITUS AND CORONARY HEART DISEASE

In recent years, the growth in the number of diabetic patients has been registered in the most countries. In turn, the diseases of the cardiovascular system are still the leading cause of death in many countries. Against the background of rapid growth in the incidence of diabetes mellitus, the numbe...

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Autores principales:	T. P. Bardymova, K. V. Protasov, S. S. Tsyretorova, O. S. Donirova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2017
Materias:	type 2 diabetes mellitus coronary heart disease endothelial dysfunction cytokines Science Q
Acceso en línea:	https://doaj.org/article/3bb8b5920b51443294ea08e86f46db15
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spelling	oai:doaj.org-article:3bb8b5920b51443294ea08e86f46db152021-11-23T06:14:36ZTYPE 2 DIABETES MELLITUS AND CORONARY HEART DISEASE2541-94202587-959610.12737/article_5955e6b60d5bf2.66416553https://doaj.org/article/3bb8b5920b51443294ea08e86f46db152017-02-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/372https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596In recent years, the growth in the number of diabetic patients has been registered in the most countries. In turn, the diseases of the cardiovascular system are still the leading cause of death in many countries. Against the background of rapid growth in the incidence of diabetes mellitus, the number of patients with combined pathology including coronary heart disease and type 2 diabetes mellitus increases. Oxidation of LDL with the subsequent generation of cytokines and other biologically active molecules is considered one of the major pathogenic mechanisms of atherosclerosis. Hyperglycemia contributes to the processes of lipid peroxidation with activation of atherogenesis with increased risk of vascular lesions. The modern views on commonality of the mechanisms of the development of diabetes and coronary heart disease are studied. Attention is paid to the generation of free radicals, which being highly reactive unstable chemical compounds damage the endothelium. However, activation of free radical processes in the conditions of hyperglycemia stimulate the increased synthesis of pro-inflammatory cytokines, including necrosisfactor-a tumor, interleukins, which are a reflection of local and systemic inflammation. This review presents detailed description of the main pro-inflammatory cytokines (interleukin-1ß, interleukin-6, interleukin-8, TNF-a) and C-reactive protein. The value of insulin resistance and hyperfibrinogenemia in diabetes mellitus combined with coronary heart disease and the factors, which increase the risk for adverse outcomes of coronary heart disease, is presented in the article.T. P. BardymovaK. V. ProtasovS. S. TsyretorovaO. S. DonirovaScientific Сentre for Family Health and Human Reproduction Problemsarticletype 2 diabetes mellituscoronary heart diseaseendothelial dysfunctioncytokinesScienceQRUActa Biomedica Scientifica, Vol 2, Iss 1, Pp 100-106 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	type 2 diabetes mellitus coronary heart disease endothelial dysfunction cytokines Science Q
spellingShingle	type 2 diabetes mellitus coronary heart disease endothelial dysfunction cytokines Science Q T. P. Bardymova K. V. Protasov S. S. Tsyretorova O. S. Donirova TYPE 2 DIABETES MELLITUS AND CORONARY HEART DISEASE
description	In recent years, the growth in the number of diabetic patients has been registered in the most countries. In turn, the diseases of the cardiovascular system are still the leading cause of death in many countries. Against the background of rapid growth in the incidence of diabetes mellitus, the number of patients with combined pathology including coronary heart disease and type 2 diabetes mellitus increases. Oxidation of LDL with the subsequent generation of cytokines and other biologically active molecules is considered one of the major pathogenic mechanisms of atherosclerosis. Hyperglycemia contributes to the processes of lipid peroxidation with activation of atherogenesis with increased risk of vascular lesions. The modern views on commonality of the mechanisms of the development of diabetes and coronary heart disease are studied. Attention is paid to the generation of free radicals, which being highly reactive unstable chemical compounds damage the endothelium. However, activation of free radical processes in the conditions of hyperglycemia stimulate the increased synthesis of pro-inflammatory cytokines, including necrosisfactor-a tumor, interleukins, which are a reflection of local and systemic inflammation. This review presents detailed description of the main pro-inflammatory cytokines (interleukin-1ß, interleukin-6, interleukin-8, TNF-a) and C-reactive protein. The value of insulin resistance and hyperfibrinogenemia in diabetes mellitus combined with coronary heart disease and the factors, which increase the risk for adverse outcomes of coronary heart disease, is presented in the article.
format	article
author	T. P. Bardymova K. V. Protasov S. S. Tsyretorova O. S. Donirova
author_facet	T. P. Bardymova K. V. Protasov S. S. Tsyretorova O. S. Donirova
author_sort	T. P. Bardymova
title	TYPE 2 DIABETES MELLITUS AND CORONARY HEART DISEASE
title_short	TYPE 2 DIABETES MELLITUS AND CORONARY HEART DISEASE
title_full	TYPE 2 DIABETES MELLITUS AND CORONARY HEART DISEASE
title_fullStr	TYPE 2 DIABETES MELLITUS AND CORONARY HEART DISEASE
title_full_unstemmed	TYPE 2 DIABETES MELLITUS AND CORONARY HEART DISEASE
title_sort	type 2 diabetes mellitus and coronary heart disease
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2017
url	https://doaj.org/article/3bb8b5920b51443294ea08e86f46db15
work_keys_str_mv	AT tpbardymova type2diabetesmellitusandcoronaryheartdisease AT kvprotasov type2diabetesmellitusandcoronaryheartdisease AT sstsyretorova type2diabetesmellitusandcoronaryheartdisease AT osdonirova type2diabetesmellitusandcoronaryheartdisease
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TYPE 2 DIABETES MELLITUS AND CORONARY HEART DISEASE

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