Advances in the diagnosis and management of lymphoma

Zachary H Word1, Matthew J Matasar1,21Lymphoma Service, Department of Medicine, Memorial Sloan&ndash;Kettering Cancer Center, 2Department of Medicine, New York Presbyterian Hospital, New York, NY, USAAbstract: The lymphomas are a heterogeneous group of cancers that have played a prominent ro...

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Autores principales:	Matasar MJ, Word ZH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/3bba9cece3794f308c6fb307322869b4
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spelling	oai:doaj.org-article:3bba9cece3794f308c6fb307322869b42021-12-02T00:57:28ZAdvances in the diagnosis and management of lymphoma1179-9889https://doaj.org/article/3bba9cece3794f308c6fb307322869b42012-02-01T00:00:00Zhttp://www.dovepress.com/advances-in-the-diagnosis-and-management-of-lymphoma-a9203https://doaj.org/toc/1179-9889Zachary H Word1, Matthew J Matasar1,21Lymphoma Service, Department of Medicine, Memorial Sloan&ndash;Kettering Cancer Center, 2Department of Medicine, New York Presbyterian Hospital, New York, NY, USAAbstract: The lymphomas are a heterogeneous group of cancers that have played a prominent role in the history of oncology, being among the first cancers to respond to radiotherapy or systemic chemotherapy. Progressive improvement in the understanding of the biology and natural history of these diseases has led to changes in both classification and management. Because of the heterogeneity present among the lymphomas, accurate diagnosis and staging are essential prerequisites to their effective management. Lymphoma stage frequently informs treatment decisions, but in contrast with solid tumor malignancies carries limited prognostic value. This has led to the development of prognostic models in lymphoma, which use patient and disease characteristics to stratify patients by risk. Modern approaches to Hodgkin&#39;s lymphoma include chemotherapy only, combined-modality therapy with both chemotherapy and radiotherapy, and risk-adapted approaches that modify treatment based on initial response. Management of non-Hodgkin&#39;s lymphoma (NHL) varies widely depending upon histology. Use of rituximab, the anti-CD20 monoclonal antibody, is included in the management of most B cell lymphomas and has improved outcomes in these diseases. The T cell lymphomas are less common and generally less well understood than the B cell diseases, and their management has only recently become disease-specific. Though effective therapy is available for many types of lymphoma, relapse remains common in a number of subtypes, and management of relapsed and refractory disease remain research priorities.Keywords: lymphoma, diagnosis, treatmentMatasar MJWord ZHDove Medical PressarticleDiseases of the blood and blood-forming organsRC633-647.5ENBlood and Lymphatic Cancer: Targets and Therapy, Vol 2012, Iss default, Pp 29-55 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Diseases of the blood and blood-forming organs RC633-647.5 Matasar MJ Word ZH Advances in the diagnosis and management of lymphoma
description	Zachary H Word1, Matthew J Matasar1,21Lymphoma Service, Department of Medicine, Memorial Sloan&ndash;Kettering Cancer Center, 2Department of Medicine, New York Presbyterian Hospital, New York, NY, USAAbstract: The lymphomas are a heterogeneous group of cancers that have played a prominent role in the history of oncology, being among the first cancers to respond to radiotherapy or systemic chemotherapy. Progressive improvement in the understanding of the biology and natural history of these diseases has led to changes in both classification and management. Because of the heterogeneity present among the lymphomas, accurate diagnosis and staging are essential prerequisites to their effective management. Lymphoma stage frequently informs treatment decisions, but in contrast with solid tumor malignancies carries limited prognostic value. This has led to the development of prognostic models in lymphoma, which use patient and disease characteristics to stratify patients by risk. Modern approaches to Hodgkin&#39;s lymphoma include chemotherapy only, combined-modality therapy with both chemotherapy and radiotherapy, and risk-adapted approaches that modify treatment based on initial response. Management of non-Hodgkin&#39;s lymphoma (NHL) varies widely depending upon histology. Use of rituximab, the anti-CD20 monoclonal antibody, is included in the management of most B cell lymphomas and has improved outcomes in these diseases. The T cell lymphomas are less common and generally less well understood than the B cell diseases, and their management has only recently become disease-specific. Though effective therapy is available for many types of lymphoma, relapse remains common in a number of subtypes, and management of relapsed and refractory disease remain research priorities.Keywords: lymphoma, diagnosis, treatment
format	article
author	Matasar MJ Word ZH
author_facet	Matasar MJ Word ZH
author_sort	Matasar MJ
title	Advances in the diagnosis and management of lymphoma
title_short	Advances in the diagnosis and management of lymphoma
title_full	Advances in the diagnosis and management of lymphoma
title_fullStr	Advances in the diagnosis and management of lymphoma
title_full_unstemmed	Advances in the diagnosis and management of lymphoma
title_sort	advances in the diagnosis and management of lymphoma
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/3bba9cece3794f308c6fb307322869b4
work_keys_str_mv	AT matasarmj advancesinthediagnosisandmanagementoflymphoma AT wordzh advancesinthediagnosisandmanagementoflymphoma
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Advances in the diagnosis and management of lymphoma

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