Evaluation of neurotrophic factors and education level as predictors of cognitive decline in alcohol use disorder

Abstract Cognitive reserve (CR) is the capability of an individual to cope with a brain pathology through compensatory mechanisms developed through cognitive stimulation by mental and physical activity. Recently, it has been suggested that CR has a protective role against the initiation of substance...

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Autores principales:	Nerea Requena-Ocaña, Pedro Araos, María Flores, Nuria García-Marchena, Daniel Silva-Peña, Jesús Aranda, Patricia Rivera, Juan Jesús Ruiz, Antonia Serrano, Francisco Javier Pavón, Juan Suárez, Fernando Rodríguez de Fonseca
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3bbe73478fad4ab7824f0f90e1fd6e05
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spelling	oai:doaj.org-article:3bbe73478fad4ab7824f0f90e1fd6e052021-12-02T14:53:42ZEvaluation of neurotrophic factors and education level as predictors of cognitive decline in alcohol use disorder10.1038/s41598-021-95131-22045-2322https://doaj.org/article/3bbe73478fad4ab7824f0f90e1fd6e052021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95131-2https://doaj.org/toc/2045-2322Abstract Cognitive reserve (CR) is the capability of an individual to cope with a brain pathology through compensatory mechanisms developed through cognitive stimulation by mental and physical activity. Recently, it has been suggested that CR has a protective role against the initiation of substance use, substance consumption patterns and cognitive decline and can improve responses to treatment. However, CR has never been linked to cognitive function and neurotrophic factors in the context of alcohol consumption. The present cross-sectional study aims to evaluate the association between CR (evaluated by educational level), cognitive impairment (assessed using a frontal and memory loss assessment battery) and circulating levels of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) in patients with alcohol use disorder (AUD). Our results indicated that lower educational levels were accompanied by earlier onset of alcohol consumption and earlier development of alcohol dependence, as well as impaired frontal cognitive function. They also suggest that CR, NT-3 and BDNF may act as compensatory mechanisms for cognitive decline in the early stages of AUD, but not in later phases. These parameters allow the identification of patients with AUD who are at risk of cognitive deterioration and the implementation of personalized interventions to preserve cognitive function.Nerea Requena-OcañaPedro AraosMaría FloresNuria García-MarchenaDaniel Silva-PeñaJesús ArandaPatricia RiveraJuan Jesús RuizAntonia SerranoFrancisco Javier PavónJuan SuárezFernando Rodríguez de FonsecaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nerea Requena-Ocaña Pedro Araos María Flores Nuria García-Marchena Daniel Silva-Peña Jesús Aranda Patricia Rivera Juan Jesús Ruiz Antonia Serrano Francisco Javier Pavón Juan Suárez Fernando Rodríguez de Fonseca Evaluation of neurotrophic factors and education level as predictors of cognitive decline in alcohol use disorder
description	Abstract Cognitive reserve (CR) is the capability of an individual to cope with a brain pathology through compensatory mechanisms developed through cognitive stimulation by mental and physical activity. Recently, it has been suggested that CR has a protective role against the initiation of substance use, substance consumption patterns and cognitive decline and can improve responses to treatment. However, CR has never been linked to cognitive function and neurotrophic factors in the context of alcohol consumption. The present cross-sectional study aims to evaluate the association between CR (evaluated by educational level), cognitive impairment (assessed using a frontal and memory loss assessment battery) and circulating levels of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) in patients with alcohol use disorder (AUD). Our results indicated that lower educational levels were accompanied by earlier onset of alcohol consumption and earlier development of alcohol dependence, as well as impaired frontal cognitive function. They also suggest that CR, NT-3 and BDNF may act as compensatory mechanisms for cognitive decline in the early stages of AUD, but not in later phases. These parameters allow the identification of patients with AUD who are at risk of cognitive deterioration and the implementation of personalized interventions to preserve cognitive function.
format	article
author	Nerea Requena-Ocaña Pedro Araos María Flores Nuria García-Marchena Daniel Silva-Peña Jesús Aranda Patricia Rivera Juan Jesús Ruiz Antonia Serrano Francisco Javier Pavón Juan Suárez Fernando Rodríguez de Fonseca
author_facet	Nerea Requena-Ocaña Pedro Araos María Flores Nuria García-Marchena Daniel Silva-Peña Jesús Aranda Patricia Rivera Juan Jesús Ruiz Antonia Serrano Francisco Javier Pavón Juan Suárez Fernando Rodríguez de Fonseca
author_sort	Nerea Requena-Ocaña
title	Evaluation of neurotrophic factors and education level as predictors of cognitive decline in alcohol use disorder
title_short	Evaluation of neurotrophic factors and education level as predictors of cognitive decline in alcohol use disorder
title_full	Evaluation of neurotrophic factors and education level as predictors of cognitive decline in alcohol use disorder
title_fullStr	Evaluation of neurotrophic factors and education level as predictors of cognitive decline in alcohol use disorder
title_full_unstemmed	Evaluation of neurotrophic factors and education level as predictors of cognitive decline in alcohol use disorder
title_sort	evaluation of neurotrophic factors and education level as predictors of cognitive decline in alcohol use disorder
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3bbe73478fad4ab7824f0f90e1fd6e05
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Evaluation of neurotrophic factors and education level as predictors of cognitive decline in alcohol use disorder

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