Structural basis for TNA synthesis by an engineered TNA polymerase

The laboratory-evolved polymerase Kod-RI catalyzes α-L-threose nucleic acid (TNA) synthesis. Here, the authors present Kod-RI crystal structures that give insights into how TNA triphosphates are selected and extended in a template-dependent manner, which will help to engineer improved TNA polymerase...

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Autores principales:	Nicholas Chim, Changhua Shi, Sujay P. Sau, Ali Nikoomanzar, John C. Chaput
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3bbeaf8d41a942a9b6a734d7962c9baa
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spelling	oai:doaj.org-article:3bbeaf8d41a942a9b6a734d7962c9baa2021-12-02T14:41:10ZStructural basis for TNA synthesis by an engineered TNA polymerase10.1038/s41467-017-02014-02041-1723https://doaj.org/article/3bbeaf8d41a942a9b6a734d7962c9baa2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02014-0https://doaj.org/toc/2041-1723The laboratory-evolved polymerase Kod-RI catalyzes α-L-threose nucleic acid (TNA) synthesis. Here, the authors present Kod-RI crystal structures that give insights into how TNA triphosphates are selected and extended in a template-dependent manner, which will help to engineer improved TNA polymerases for synthetic genetics applications.Nicholas ChimChanghua ShiSujay P. SauAli NikoomanzarJohn C. ChaputNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicholas Chim Changhua Shi Sujay P. Sau Ali Nikoomanzar John C. Chaput Structural basis for TNA synthesis by an engineered TNA polymerase
description	The laboratory-evolved polymerase Kod-RI catalyzes α-L-threose nucleic acid (TNA) synthesis. Here, the authors present Kod-RI crystal structures that give insights into how TNA triphosphates are selected and extended in a template-dependent manner, which will help to engineer improved TNA polymerases for synthetic genetics applications.
format	article
author	Nicholas Chim Changhua Shi Sujay P. Sau Ali Nikoomanzar John C. Chaput
author_facet	Nicholas Chim Changhua Shi Sujay P. Sau Ali Nikoomanzar John C. Chaput
author_sort	Nicholas Chim
title	Structural basis for TNA synthesis by an engineered TNA polymerase
title_short	Structural basis for TNA synthesis by an engineered TNA polymerase
title_full	Structural basis for TNA synthesis by an engineered TNA polymerase
title_fullStr	Structural basis for TNA synthesis by an engineered TNA polymerase
title_full_unstemmed	Structural basis for TNA synthesis by an engineered TNA polymerase
title_sort	structural basis for tna synthesis by an engineered tna polymerase
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3bbeaf8d41a942a9b6a734d7962c9baa
work_keys_str_mv	AT nicholaschim structuralbasisfortnasynthesisbyanengineeredtnapolymerase AT changhuashi structuralbasisfortnasynthesisbyanengineeredtnapolymerase AT sujaypsau structuralbasisfortnasynthesisbyanengineeredtnapolymerase AT alinikoomanzar structuralbasisfortnasynthesisbyanengineeredtnapolymerase AT johncchaput structuralbasisfortnasynthesisbyanengineeredtnapolymerase
_version_	1718389984445071360

Structural basis for TNA synthesis by an engineered TNA polymerase

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