Structural basis for TNA synthesis by an engineered TNA polymerase

Structural basis for TNA synthesis by an engineered TNA polymerase

The laboratory-evolved polymerase Kod-RI catalyzes α-L-threose nucleic acid (TNA) synthesis. Here, the authors present Kod-RI crystal structures that give insights into how TNA triphosphates are selected and extended in a template-dependent manner, which will help to engineer improved TNA polymerase...

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Autores principales: Nicholas Chim, Changhua Shi, Sujay P. Sau, Ali Nikoomanzar, John C. Chaput
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/3bbeaf8d41a942a9b6a734d7962c9baa
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