Chemogenetic modulation of sensory neurons reveals their regulating role in melanoma progression

Chemogenetic modulation of sensory neurons reveals their regulating role in melanoma progression

Abstract Sensory neurons have recently emerged as components of the tumor microenvironment. Nevertheless, whether sensory neuronal activity is important for tumor progression remains unknown. Here we used Designer Receptors Exclusively Activated by a Designer Drug (DREADD) technology to inhibit or a...

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Autores principales: Pedro A. C. Costa, Walison N. Silva, Pedro H. D. M. Prazeres, Caroline C. Picoli, Gabriela D. A. Guardia, Alinne C. Costa, Mariana A. Oliveira, Pedro P. G. Guimarães, Ricardo Gonçalves, Mauro C. X. Pinto, Jaime H. Amorim, Vasco A. C. Azevedo, Rodrigo R. Resende, Remo C. Russo, Thiago M. Cunha, Pedro A. F. Galante, Akiva Mintz, Alexander Birbrair
Formato: article
Lenguaje:EN
Publicado: BMC 2021
Materias:
Sensory neurons
Tumor microenvironment
Melanoma
Neuronal activity
Chemogenetics
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/3bc21826b70242beab95f440ca474ea2
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