Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failure

Heart failure has a heterogeneous etiology and the genetic underpinnings are not well understood. Here, Arvanitis et al. perform GWAS meta-analysis including 10,976 heart failure cases and 437,573 controls, identify new loci near ABO and ACTN2 and show that deletion of a ACTN2 enhancer leads to redu...

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Autores principales:	Marios Arvanitis, Emmanouil Tampakakis, Yanxiao Zhang, Wei Wang, Adam Auton, 23andMe Research Team, Diptavo Dutta, Stephanie Glavaris, Ali Keramati, Nilanjan Chatterjee, Neil C. Chi, Bing Ren, Wendy S. Post, Alexis Battle
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3bc2253203ec49828e938618eb6f185d
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spelling	oai:doaj.org-article:3bc2253203ec49828e938618eb6f185d2021-12-02T14:40:41ZGenome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failure10.1038/s41467-020-14843-72041-1723https://doaj.org/article/3bc2253203ec49828e938618eb6f185d2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14843-7https://doaj.org/toc/2041-1723Heart failure has a heterogeneous etiology and the genetic underpinnings are not well understood. Here, Arvanitis et al. perform GWAS meta-analysis including 10,976 heart failure cases and 437,573 controls, identify new loci near ABO and ACTN2 and show that deletion of a ACTN2 enhancer leads to reduced ACTN2 expression in differentiating cardiomyocytes.Marios ArvanitisEmmanouil TampakakisYanxiao ZhangWei WangAdam Auton23andMe Research TeamDiptavo DuttaStephanie GlavarisAli KeramatiNilanjan ChatterjeeNeil C. ChiBing RenWendy S. PostAlexis BattleNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marios Arvanitis Emmanouil Tampakakis Yanxiao Zhang Wei Wang Adam Auton 23andMe Research Team Diptavo Dutta Stephanie Glavaris Ali Keramati Nilanjan Chatterjee Neil C. Chi Bing Ren Wendy S. Post Alexis Battle Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failure
description	Heart failure has a heterogeneous etiology and the genetic underpinnings are not well understood. Here, Arvanitis et al. perform GWAS meta-analysis including 10,976 heart failure cases and 437,573 controls, identify new loci near ABO and ACTN2 and show that deletion of a ACTN2 enhancer leads to reduced ACTN2 expression in differentiating cardiomyocytes.
format	article
author	Marios Arvanitis Emmanouil Tampakakis Yanxiao Zhang Wei Wang Adam Auton 23andMe Research Team Diptavo Dutta Stephanie Glavaris Ali Keramati Nilanjan Chatterjee Neil C. Chi Bing Ren Wendy S. Post Alexis Battle
author_facet	Marios Arvanitis Emmanouil Tampakakis Yanxiao Zhang Wei Wang Adam Auton 23andMe Research Team Diptavo Dutta Stephanie Glavaris Ali Keramati Nilanjan Chatterjee Neil C. Chi Bing Ren Wendy S. Post Alexis Battle
author_sort	Marios Arvanitis
title	Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failure
title_short	Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failure
title_full	Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failure
title_fullStr	Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failure
title_full_unstemmed	Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failure
title_sort	genome-wide association and multi-omic analyses reveal actn2 as a gene linked to heart failure
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3bc2253203ec49828e938618eb6f185d
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Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failure

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