Predictive Utility of Body Mass Index for Metabolic Syndrome Among Patients with Schizophrenia in Japan

Predictive Utility of Body Mass Index for Metabolic Syndrome Among Patients with Schizophrenia in Japan

Norio Sugawara,1,2 Norio Yasui-Furukori,1,2 Manabu Yamazaki,3 Kazutaka Shimoda,1,2 Takao Mori,3 Takuro Sugai,2,4 Hiroshi Matsuda,3 Yutaro Suzuki,2,4 Yuji Ozeki,2,5 Kurefu Okamoto,3 Toyoaki Sagae,3,6 Toshiyuki Someya2,4 1Department of Psychiatry, Dokkyo Medical University School of Medicine, Mibu, To...

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Autores principales: Sugawara N, Yasui-Furukori N, Yamazaki M, Shimoda K, Mori T, Sugai T, Matsuda H, Suzuki Y, Ozeki Y, Okamoto K, Sagae T, Someya T
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2020
Materias:
body mass index
metabolic syndrome
schizoaffective disorder
schizophrenia
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/3bc4415ae3324ff984831d892d6a342e
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spelling oai:doaj.org-article:3bc4415ae3324ff984831d892d6a342e2021-12-02T11:22:24ZPredictive Utility of Body Mass Index for Metabolic Syndrome Among Patients with Schizophrenia in Japan1178-2021https://doaj.org/article/3bc4415ae3324ff984831d892d6a342e2020-09-01T00:00:00Zhttps://www.dovepress.com/predictive-utility-of-body-mass-index-for-metabolic-syndrome-among-pat-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Norio Sugawara,1,2 Norio Yasui-Furukori,1,2 Manabu Yamazaki,3 Kazutaka Shimoda,1,2 Takao Mori,3 Takuro Sugai,2,4 Hiroshi Matsuda,3 Yutaro Suzuki,2,4 Yuji Ozeki,2,5 Kurefu Okamoto,3 Toyoaki Sagae,3,6 Toshiyuki Someya2,4 1Department of Psychiatry, Dokkyo Medical University School of Medicine, Mibu, Tochigi 321-0293, Japan; 2Japanese Society of Clinical Neuropsychopharmacology, Chiyoda-ku, Tokyo 101-0003, Japan; 3Japan Psychiatric Hospital Association, Minato-ku, Tokyo 108-8554, Japan; 4Department of Psychiatry, Graduate School of Medical and Dental Sciences, Niigata University, Chuo-ku, Niigata 951-8510, Japan; 5Department of Psychiatry, Shiga University of Medical Science, Otsu, Shiga 520-2134, Japan; 6Department of Health and Nutrition, Yamagata Prefectural Yonezawa University of Nutrition Sciences, Yonezawa, Yamagata 992-0025, JapanCorrespondence: Norio SugawaraDepartment of Psychiatry, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi 321-0293, JapanTel +81-28-287-2153 (extension: 7141)Fax +81-28-286-5187Email nsuga3@dokkyomed.ac.jpBackground: Reliable and easy screening for metabolic syndrome (MetS) is important for patients with schizophrenia. The aim of this study was to assess the predictive utility of body mass index (BMI) for MetS among patients with schizophrenia in Japan.Methods: In total, 8468 patients (4705 males, 3763 females) with schizophrenia or schizoaffective disorders based on the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV), or the International Classification of Diseases, tenth revision (ICD-10), were assessed for MetS using the criteria of the National Cholesterol Education Program Adult Treatment Panel III (ATP III-A). We applied a stratum-specific likelihood ratio (SSLR) analysis, which is independent of the prevalence of the target disease.Results: The mean (± standard deviation) age of these patients was 57.4 ± 13.5 years. The prevalence of MetS was 20.4%. Among males, the SSLRs predicting MetS were 0.03 (95% CI 0.02– 0.06), 0.54 (95% CI 0.48– 0.60), 2.77 (95% CI 2.44– 3.14) and 8.75 (95% CI 7.40– 10.36) for BMI < 20 kg/m2, 20 kg/m2 ≤ BMI < 25 kg/m2, 25 kg/m2≤ BMI < 28 kg/m2, and 28 kg/m2≤BMI, respectively. For females, the SSLRs predicting MetS were 0.08 (95% CI 0.05– 0.12), 0.73 (95% CI 0.66– 0.82), 2.50 (95% CI 2.16– 2.90) and 4.83 (95% CI 4.12– 5.67) for the same BMI categories, respectively.Conclusion: The predictive utility of BMI is confirmed, and BMI has more predictive value in males than in females. Patients with a BMI of 28 kg/m2 or greater had a significantly higher SSLR than those with a BMI less than 28 kg/m2.Keywords: body mass index, metabolic syndrome, schizoaffective disorder, schizophreniaSugawara NYasui-Furukori NYamazaki MShimoda KMori TSugai TMatsuda HSuzuki YOzeki YOkamoto KSagae TSomeya TDove Medical Pressarticlebody mass indexmetabolic syndromeschizoaffective disorderschizophreniaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 2229-2236 (2020)
institution DOAJ
collection DOAJ
language EN
topic body mass index
metabolic syndrome
schizoaffective disorder
schizophrenia
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle body mass index
metabolic syndrome
schizoaffective disorder
schizophrenia
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Sugawara N
Yasui-Furukori N
Yamazaki M
Shimoda K
Mori T
Sugai T
Matsuda H
Suzuki Y
Ozeki Y
Okamoto K
Sagae T
Someya T
Predictive Utility of Body Mass Index for Metabolic Syndrome Among Patients with Schizophrenia in Japan
description Norio Sugawara,1,2 Norio Yasui-Furukori,1,2 Manabu Yamazaki,3 Kazutaka Shimoda,1,2 Takao Mori,3 Takuro Sugai,2,4 Hiroshi Matsuda,3 Yutaro Suzuki,2,4 Yuji Ozeki,2,5 Kurefu Okamoto,3 Toyoaki Sagae,3,6 Toshiyuki Someya2,4 1Department of Psychiatry, Dokkyo Medical University School of Medicine, Mibu, Tochigi 321-0293, Japan; 2Japanese Society of Clinical Neuropsychopharmacology, Chiyoda-ku, Tokyo 101-0003, Japan; 3Japan Psychiatric Hospital Association, Minato-ku, Tokyo 108-8554, Japan; 4Department of Psychiatry, Graduate School of Medical and Dental Sciences, Niigata University, Chuo-ku, Niigata 951-8510, Japan; 5Department of Psychiatry, Shiga University of Medical Science, Otsu, Shiga 520-2134, Japan; 6Department of Health and Nutrition, Yamagata Prefectural Yonezawa University of Nutrition Sciences, Yonezawa, Yamagata 992-0025, JapanCorrespondence: Norio SugawaraDepartment of Psychiatry, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi 321-0293, JapanTel +81-28-287-2153 (extension: 7141)Fax +81-28-286-5187Email nsuga3@dokkyomed.ac.jpBackground: Reliable and easy screening for metabolic syndrome (MetS) is important for patients with schizophrenia. The aim of this study was to assess the predictive utility of body mass index (BMI) for MetS among patients with schizophrenia in Japan.Methods: In total, 8468 patients (4705 males, 3763 females) with schizophrenia or schizoaffective disorders based on the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV), or the International Classification of Diseases, tenth revision (ICD-10), were assessed for MetS using the criteria of the National Cholesterol Education Program Adult Treatment Panel III (ATP III-A). We applied a stratum-specific likelihood ratio (SSLR) analysis, which is independent of the prevalence of the target disease.Results: The mean (± standard deviation) age of these patients was 57.4 ± 13.5 years. The prevalence of MetS was 20.4%. Among males, the SSLRs predicting MetS were 0.03 (95% CI 0.02– 0.06), 0.54 (95% CI 0.48– 0.60), 2.77 (95% CI 2.44– 3.14) and 8.75 (95% CI 7.40– 10.36) for BMI < 20 kg/m2, 20 kg/m2 ≤ BMI < 25 kg/m2, 25 kg/m2≤ BMI < 28 kg/m2, and 28 kg/m2≤BMI, respectively. For females, the SSLRs predicting MetS were 0.08 (95% CI 0.05– 0.12), 0.73 (95% CI 0.66– 0.82), 2.50 (95% CI 2.16– 2.90) and 4.83 (95% CI 4.12– 5.67) for the same BMI categories, respectively.Conclusion: The predictive utility of BMI is confirmed, and BMI has more predictive value in males than in females. Patients with a BMI of 28 kg/m2 or greater had a significantly higher SSLR than those with a BMI less than 28 kg/m2.Keywords: body mass index, metabolic syndrome, schizoaffective disorder, schizophrenia
format article
author Sugawara N
Yasui-Furukori N
Yamazaki M
Shimoda K
Mori T
Sugai T
Matsuda H
Suzuki Y
Ozeki Y
Okamoto K
Sagae T
Someya T
author_facet Sugawara N
Yasui-Furukori N
Yamazaki M
Shimoda K
Mori T
Sugai T
Matsuda H
Suzuki Y
Ozeki Y
Okamoto K
Sagae T
Someya T
author_sort Sugawara N
title Predictive Utility of Body Mass Index for Metabolic Syndrome Among Patients with Schizophrenia in Japan
title_short Predictive Utility of Body Mass Index for Metabolic Syndrome Among Patients with Schizophrenia in Japan
title_full Predictive Utility of Body Mass Index for Metabolic Syndrome Among Patients with Schizophrenia in Japan
title_fullStr Predictive Utility of Body Mass Index for Metabolic Syndrome Among Patients with Schizophrenia in Japan
title_full_unstemmed Predictive Utility of Body Mass Index for Metabolic Syndrome Among Patients with Schizophrenia in Japan
title_sort predictive utility of body mass index for metabolic syndrome among patients with schizophrenia in japan
publisher Dove Medical Press
publishDate 2020
url https://doaj.org/article/3bc4415ae3324ff984831d892d6a342e
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