Biodegradable elastic nanofibrous platforms with integrated flexible heaters for on-demand drug delivery

Abstract Delivery of drugs with controlled temporal profiles is essential for wound treatment and regenerative medicine applications. For example, bacterial infection is a key challenge in the treatment of chronic and deep wounds. Current treatment strategies are based on systemic administration of...

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Autores principales:	Ali Tamayol, Alireza Hassani Najafabadi, Pooria Mostafalu, Ali K. Yetisen, Mattia Commotto, Musab Aldhahri, Mohamed Shaaban Abdel-wahab, Zeynab Izadi Najafabadi, Shahrzad Latifi, Mohsen Akbari, Nasim Annabi, Seok Hyun Yun, Adnan Memic, Mehmet R. Dokmeci, Ali Khademhosseini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3bc86ce1e5c6402fa24373609a852260
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spelling	oai:doaj.org-article:3bc86ce1e5c6402fa24373609a8522602021-12-02T11:41:12ZBiodegradable elastic nanofibrous platforms with integrated flexible heaters for on-demand drug delivery10.1038/s41598-017-04749-82045-2322https://doaj.org/article/3bc86ce1e5c6402fa24373609a8522602017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04749-8https://doaj.org/toc/2045-2322Abstract Delivery of drugs with controlled temporal profiles is essential for wound treatment and regenerative medicine applications. For example, bacterial infection is a key challenge in the treatment of chronic and deep wounds. Current treatment strategies are based on systemic administration of high doses of antibiotics, which result in side effects and drug resistance. On-demand delivery of drugs with controlled temporal profile is highly desirable. Here, we have developed thermally controllable, antibiotic-releasing nanofibrous sheets. Poly(glycerol sebacate)- poly(caprolactone) (PGS-PCL) blends were electrospun to form elastic polymeric sheets with fiber diameters ranging from 350 to 1100 nm and substrates with a tensile modulus of approximately 4-8 MPa. A bioresorbable metallic heater was patterned directly on the nanofibrous substrate for applying thermal stimulation to release antibiotics on-demand. In vitro studies confirmed the platform’s biocompatibility and biodegradability. The released antibiotics were potent against tested bacterial strains. These results may pave the path toward developing electronically controllable wound dressings that can deliver drugs with desired temporal patterns.Ali TamayolAlireza Hassani NajafabadiPooria MostafaluAli K. YetisenMattia CommottoMusab AldhahriMohamed Shaaban Abdel-wahabZeynab Izadi NajafabadiShahrzad LatifiMohsen AkbariNasim AnnabiSeok Hyun YunAdnan MemicMehmet R. DokmeciAli KhademhosseiniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ali Tamayol Alireza Hassani Najafabadi Pooria Mostafalu Ali K. Yetisen Mattia Commotto Musab Aldhahri Mohamed Shaaban Abdel-wahab Zeynab Izadi Najafabadi Shahrzad Latifi Mohsen Akbari Nasim Annabi Seok Hyun Yun Adnan Memic Mehmet R. Dokmeci Ali Khademhosseini Biodegradable elastic nanofibrous platforms with integrated flexible heaters for on-demand drug delivery
description	Abstract Delivery of drugs with controlled temporal profiles is essential for wound treatment and regenerative medicine applications. For example, bacterial infection is a key challenge in the treatment of chronic and deep wounds. Current treatment strategies are based on systemic administration of high doses of antibiotics, which result in side effects and drug resistance. On-demand delivery of drugs with controlled temporal profile is highly desirable. Here, we have developed thermally controllable, antibiotic-releasing nanofibrous sheets. Poly(glycerol sebacate)- poly(caprolactone) (PGS-PCL) blends were electrospun to form elastic polymeric sheets with fiber diameters ranging from 350 to 1100 nm and substrates with a tensile modulus of approximately 4-8 MPa. A bioresorbable metallic heater was patterned directly on the nanofibrous substrate for applying thermal stimulation to release antibiotics on-demand. In vitro studies confirmed the platform’s biocompatibility and biodegradability. The released antibiotics were potent against tested bacterial strains. These results may pave the path toward developing electronically controllable wound dressings that can deliver drugs with desired temporal patterns.
format	article
author	Ali Tamayol Alireza Hassani Najafabadi Pooria Mostafalu Ali K. Yetisen Mattia Commotto Musab Aldhahri Mohamed Shaaban Abdel-wahab Zeynab Izadi Najafabadi Shahrzad Latifi Mohsen Akbari Nasim Annabi Seok Hyun Yun Adnan Memic Mehmet R. Dokmeci Ali Khademhosseini
author_facet	Ali Tamayol Alireza Hassani Najafabadi Pooria Mostafalu Ali K. Yetisen Mattia Commotto Musab Aldhahri Mohamed Shaaban Abdel-wahab Zeynab Izadi Najafabadi Shahrzad Latifi Mohsen Akbari Nasim Annabi Seok Hyun Yun Adnan Memic Mehmet R. Dokmeci Ali Khademhosseini
author_sort	Ali Tamayol
title	Biodegradable elastic nanofibrous platforms with integrated flexible heaters for on-demand drug delivery
title_short	Biodegradable elastic nanofibrous platforms with integrated flexible heaters for on-demand drug delivery
title_full	Biodegradable elastic nanofibrous platforms with integrated flexible heaters for on-demand drug delivery
title_fullStr	Biodegradable elastic nanofibrous platforms with integrated flexible heaters for on-demand drug delivery
title_full_unstemmed	Biodegradable elastic nanofibrous platforms with integrated flexible heaters for on-demand drug delivery
title_sort	biodegradable elastic nanofibrous platforms with integrated flexible heaters for on-demand drug delivery
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3bc86ce1e5c6402fa24373609a852260
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Biodegradable elastic nanofibrous platforms with integrated flexible heaters for on-demand drug delivery

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