Pilot study: Comparing efficacy of 14-day triple therapy Clarithromycin versus levofloxacin on eradication of Helicobacter Pylori infection in Syrian population single-center experience

Context: Goals: To compare the efficacy of standard triple therapy with clarithromycin versus triple therapy with levofloxacin for treatment of Helicobacter pylori-positive infection in a referral hospital in Damascus, Syria. Design: pilot prospective open-label randomized controlled trial. Subjects...

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Autores principales:	Khaled Mohammad Cheha, Sawsan Omar Ali Dib, Marouf Mohammad Alhalabi
Formato:	article
Lenguaje:	EN
Publicado:	Thieme Medical and Scientific Publishers Pvt. Ltd. 2018
Materias:	clarithromycin resistance clarithromycin helicobacter pylori levofloxacin resistance levofloxacin syria triple therapy Medicine R
Acceso en línea:	https://doaj.org/article/3bced3b1e25045b2a0a4faf01d61ac94
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spelling	oai:doaj.org-article:3bced3b1e25045b2a0a4faf01d61ac942021-12-02T18:50:08ZPilot study: Comparing efficacy of 14-day triple therapy Clarithromycin versus levofloxacin on eradication of Helicobacter Pylori infection in Syrian population single-center experience2231-07702249-446410.4103/ajm.AJM_70_17https://doaj.org/article/3bced3b1e25045b2a0a4faf01d61ac942018-01-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.4103/ajm.AJM_70_17https://doaj.org/toc/2231-0770https://doaj.org/toc/2249-4464Context: Goals: To compare the efficacy of standard triple therapy with clarithromycin versus triple therapy with levofloxacin for treatment of Helicobacter pylori-positive infection in a referral hospital in Damascus, Syria. Design: pilot prospective open-label randomized controlled trial. Subjects and Methods: Eighty treatment-naive patients who tested positive for H. pylori gastric infection were randomly assigned to one of two treatment groups with randomization ratio of 50/50. Group (A) was treated with clarithromycin (500 mg), amoxicillin (1000 mg), and esomeprazole (20 mg), each twice/day for 14 days, while Group (B) was treated with levofloxacin (500 mg), amoxicillin (1000 mg), and esomeprazole (20 mg), each twice/day for 14 days.[1] After 6 weeks of treatment, all patients underwent endoscopy and biopsy to evaluate H. pylori infection eradication. Results: Forty patients were allocated in each group; 37 patients completed the follow-up in each group. Thirteen patients in Group (A) were cured, with an eradication rate of 35.1% according to per-protocol analysis (PPA) and 32.5% according to intention-to-treat analysis (ITT), while in Group (B), 11 patients were cured, with an eradication rate of 29.7% according to PPA and 27.5% according to ITT with P = 0.80. No serious adverse events reported in both the groups. Conclusions: Clarithromycin is slightly better than levofloxacin in treatment of H. pylori gastric infection, but both regimens show low effectiveness with suboptimal eradication rates in our selected population.Khaled Mohammad ChehaSawsan Omar Ali DibMarouf Mohammad AlhalabiThieme Medical and Scientific Publishers Pvt. Ltd.articleclarithromycin resistanceclarithromycinhelicobacter pylori levofloxacin resistancelevofloxacinsyriatriple therapyMedicineRENAvicenna Journal of Medicine, Vol 8, Iss 01, Pp 14-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	clarithromycin resistance clarithromycin helicobacter pylori levofloxacin resistance levofloxacin syria triple therapy Medicine R
spellingShingle	clarithromycin resistance clarithromycin helicobacter pylori levofloxacin resistance levofloxacin syria triple therapy Medicine R Khaled Mohammad Cheha Sawsan Omar Ali Dib Marouf Mohammad Alhalabi Pilot study: Comparing efficacy of 14-day triple therapy Clarithromycin versus levofloxacin on eradication of Helicobacter Pylori infection in Syrian population single-center experience
description	Context: Goals: To compare the efficacy of standard triple therapy with clarithromycin versus triple therapy with levofloxacin for treatment of Helicobacter pylori-positive infection in a referral hospital in Damascus, Syria. Design: pilot prospective open-label randomized controlled trial. Subjects and Methods: Eighty treatment-naive patients who tested positive for H. pylori gastric infection were randomly assigned to one of two treatment groups with randomization ratio of 50/50. Group (A) was treated with clarithromycin (500 mg), amoxicillin (1000 mg), and esomeprazole (20 mg), each twice/day for 14 days, while Group (B) was treated with levofloxacin (500 mg), amoxicillin (1000 mg), and esomeprazole (20 mg), each twice/day for 14 days.[1] After 6 weeks of treatment, all patients underwent endoscopy and biopsy to evaluate H. pylori infection eradication. Results: Forty patients were allocated in each group; 37 patients completed the follow-up in each group. Thirteen patients in Group (A) were cured, with an eradication rate of 35.1% according to per-protocol analysis (PPA) and 32.5% according to intention-to-treat analysis (ITT), while in Group (B), 11 patients were cured, with an eradication rate of 29.7% according to PPA and 27.5% according to ITT with P = 0.80. No serious adverse events reported in both the groups. Conclusions: Clarithromycin is slightly better than levofloxacin in treatment of H. pylori gastric infection, but both regimens show low effectiveness with suboptimal eradication rates in our selected population.
format	article
author	Khaled Mohammad Cheha Sawsan Omar Ali Dib Marouf Mohammad Alhalabi
author_facet	Khaled Mohammad Cheha Sawsan Omar Ali Dib Marouf Mohammad Alhalabi
author_sort	Khaled Mohammad Cheha
title	Pilot study: Comparing efficacy of 14-day triple therapy Clarithromycin versus levofloxacin on eradication of Helicobacter Pylori infection in Syrian population single-center experience
title_short	Pilot study: Comparing efficacy of 14-day triple therapy Clarithromycin versus levofloxacin on eradication of Helicobacter Pylori infection in Syrian population single-center experience
title_full	Pilot study: Comparing efficacy of 14-day triple therapy Clarithromycin versus levofloxacin on eradication of Helicobacter Pylori infection in Syrian population single-center experience
title_fullStr	Pilot study: Comparing efficacy of 14-day triple therapy Clarithromycin versus levofloxacin on eradication of Helicobacter Pylori infection in Syrian population single-center experience
title_full_unstemmed	Pilot study: Comparing efficacy of 14-day triple therapy Clarithromycin versus levofloxacin on eradication of Helicobacter Pylori infection in Syrian population single-center experience
title_sort	pilot study: comparing efficacy of 14-day triple therapy clarithromycin versus levofloxacin on eradication of helicobacter pylori infection in syrian population single-center experience
publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
publishDate	2018
url	https://doaj.org/article/3bced3b1e25045b2a0a4faf01d61ac94
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Pilot study: Comparing efficacy of 14-day triple therapy Clarithromycin versus levofloxacin on eradication of Helicobacter Pylori infection in Syrian population single-center experience

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