Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae

OqxB is an RND (Resistance-Nodulation-Division) transporter that contributes to the antibiotic resistance in Klebsiella pneumoniae. Here, the authors report structural and functional characterization of OqxB, with insights into its substrate binding pocket and the role in fluoroquinolone resistance.

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Autores principales:	Nagakumar Bharatham, Purnendu Bhowmik, Maho Aoki, Ui Okada, Sreevalli Sharma, Eiki Yamashita, Anirudh P. Shanbhag, Sreenath Rajagopal, Teby Thomas, Maitrayee Sarma, Riya Narjari, Savitha Nagaraj, Vasanthi Ramachandran, Nainesh Katagihallimath, Santanu Datta, Satoshi Murakami
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3bd2302c939d44e78640f6db420f1eb3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:3bd2302c939d44e78640f6db420f1eb32021-12-02T18:50:53ZStructure and function relationship of OqxB efflux pump from Klebsiella pneumoniae10.1038/s41467-021-25679-02041-1723https://doaj.org/article/3bd2302c939d44e78640f6db420f1eb32021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25679-0https://doaj.org/toc/2041-1723OqxB is an RND (Resistance-Nodulation-Division) transporter that contributes to the antibiotic resistance in Klebsiella pneumoniae. Here, the authors report structural and functional characterization of OqxB, with insights into its substrate binding pocket and the role in fluoroquinolone resistance.Nagakumar BharathamPurnendu BhowmikMaho AokiUi OkadaSreevalli SharmaEiki YamashitaAnirudh P. ShanbhagSreenath RajagopalTeby ThomasMaitrayee SarmaRiya NarjariSavitha NagarajVasanthi RamachandranNainesh KatagihallimathSantanu DattaSatoshi MurakamiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nagakumar Bharatham Purnendu Bhowmik Maho Aoki Ui Okada Sreevalli Sharma Eiki Yamashita Anirudh P. Shanbhag Sreenath Rajagopal Teby Thomas Maitrayee Sarma Riya Narjari Savitha Nagaraj Vasanthi Ramachandran Nainesh Katagihallimath Santanu Datta Satoshi Murakami Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae
description	OqxB is an RND (Resistance-Nodulation-Division) transporter that contributes to the antibiotic resistance in Klebsiella pneumoniae. Here, the authors report structural and functional characterization of OqxB, with insights into its substrate binding pocket and the role in fluoroquinolone resistance.
format	article
author	Nagakumar Bharatham Purnendu Bhowmik Maho Aoki Ui Okada Sreevalli Sharma Eiki Yamashita Anirudh P. Shanbhag Sreenath Rajagopal Teby Thomas Maitrayee Sarma Riya Narjari Savitha Nagaraj Vasanthi Ramachandran Nainesh Katagihallimath Santanu Datta Satoshi Murakami
author_facet	Nagakumar Bharatham Purnendu Bhowmik Maho Aoki Ui Okada Sreevalli Sharma Eiki Yamashita Anirudh P. Shanbhag Sreenath Rajagopal Teby Thomas Maitrayee Sarma Riya Narjari Savitha Nagaraj Vasanthi Ramachandran Nainesh Katagihallimath Santanu Datta Satoshi Murakami
author_sort	Nagakumar Bharatham
title	Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae
title_short	Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae
title_full	Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae
title_fullStr	Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae
title_full_unstemmed	Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae
title_sort	structure and function relationship of oqxb efflux pump from klebsiella pneumoniae
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3bd2302c939d44e78640f6db420f1eb3
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Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae

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