Ovarian reserve in reproductive age women with type 1 diabetes

Background: Premature aging are frequently observed among individuals with type 1 diabetes. Decrease of ovarian reserve may be one of the characteristics of such process. Aims: To evaluate the ovarian reserve function in female patients of reproductive age with type 1 diabetes in comparison with he...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Olga R. Grigoryan, Natalia S. Krasnovskaya, Robert K. Mikheev, Elena N. Andreeva, Ivan I. Dedov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2018
Materias:	anti-mullerian hormone antral follicles ovarian reserve type 1 diabetes Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/3bd63d7c08e5446d89a382a843a3aec1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3bd63d7c08e5446d89a382a843a3aec1
record_format	dspace
spelling	oai:doaj.org-article:3bd63d7c08e5446d89a382a843a3aec12021-11-14T09:00:21ZOvarian reserve in reproductive age women with type 1 diabetes2072-03512072-037810.14341/DM9480https://doaj.org/article/3bd63d7c08e5446d89a382a843a3aec12018-09-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/9480https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Background: Premature aging are frequently observed among individuals with type 1 diabetes. Decrease of ovarian reserve may be one of the characteristics of such process. Aims: To evaluate the ovarian reserve function in female patients of reproductive age with type 1 diabetes in comparison with healthy women. Materials and methods: This study evaluated 224 Caucasian women, age 18–37 years with type 1 diabetes and 230 healthy women of comparable age. Serum concentrations of anti-Mullerian hormone (AMH), inhibin B, follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol, progesterone and testosterone were compared on the 2–3 day of menstrual cycle as ovarian volume and antral follicle count (AFC). In addition, glycated hemoglobin level (HbA1c%) was evaluated. Results: We reveal statistically significant difference in following parameters in diabetic women in comparison with healthy women: AMH, AFC. But even in diabetic patients parameters remained within reference ranges. There was a pronounced negative relationship between the levels of HbA1c% and AMG. Conclusions: Ovarian reserve function parameters decrease in young women with type 1 diabetes in comparison with healthy women, but ovarian reserve parameters are in normal reference range. These findings are important in pregnancy planning consulting by gynecologists and endocrinologists. We must recommend to women with type 1 diabetes more early planning of natural pregnancy for treatment with reproductive technology in cases of prolog absence of nature pregnancy.Olga R. GrigoryanNatalia S. KrasnovskayaRobert K. MikheevElena N. AndreevaIvan I. DedovEndocrinology Research Centrearticleanti-mullerian hormoneantral folliclesovarian reservetype 1 diabetesNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 21, Iss 4, Pp 264-270 (2018)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	anti-mullerian hormone antral follicles ovarian reserve type 1 diabetes Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	anti-mullerian hormone antral follicles ovarian reserve type 1 diabetes Nutritional diseases. Deficiency diseases RC620-627 Olga R. Grigoryan Natalia S. Krasnovskaya Robert K. Mikheev Elena N. Andreeva Ivan I. Dedov Ovarian reserve in reproductive age women with type 1 diabetes
description	Background: Premature aging are frequently observed among individuals with type 1 diabetes. Decrease of ovarian reserve may be one of the characteristics of such process. Aims: To evaluate the ovarian reserve function in female patients of reproductive age with type 1 diabetes in comparison with healthy women. Materials and methods: This study evaluated 224 Caucasian women, age 18–37 years with type 1 diabetes and 230 healthy women of comparable age. Serum concentrations of anti-Mullerian hormone (AMH), inhibin B, follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol, progesterone and testosterone were compared on the 2–3 day of menstrual cycle as ovarian volume and antral follicle count (AFC). In addition, glycated hemoglobin level (HbA1c%) was evaluated. Results: We reveal statistically significant difference in following parameters in diabetic women in comparison with healthy women: AMH, AFC. But even in diabetic patients parameters remained within reference ranges. There was a pronounced negative relationship between the levels of HbA1c% and AMG. Conclusions: Ovarian reserve function parameters decrease in young women with type 1 diabetes in comparison with healthy women, but ovarian reserve parameters are in normal reference range. These findings are important in pregnancy planning consulting by gynecologists and endocrinologists. We must recommend to women with type 1 diabetes more early planning of natural pregnancy for treatment with reproductive technology in cases of prolog absence of nature pregnancy.
format	article
author	Olga R. Grigoryan Natalia S. Krasnovskaya Robert K. Mikheev Elena N. Andreeva Ivan I. Dedov
author_facet	Olga R. Grigoryan Natalia S. Krasnovskaya Robert K. Mikheev Elena N. Andreeva Ivan I. Dedov
author_sort	Olga R. Grigoryan
title	Ovarian reserve in reproductive age women with type 1 diabetes
title_short	Ovarian reserve in reproductive age women with type 1 diabetes
title_full	Ovarian reserve in reproductive age women with type 1 diabetes
title_fullStr	Ovarian reserve in reproductive age women with type 1 diabetes
title_full_unstemmed	Ovarian reserve in reproductive age women with type 1 diabetes
title_sort	ovarian reserve in reproductive age women with type 1 diabetes
publisher	Endocrinology Research Centre
publishDate	2018
url	https://doaj.org/article/3bd63d7c08e5446d89a382a843a3aec1
work_keys_str_mv	AT olgargrigoryan ovarianreserveinreproductiveagewomenwithtype1diabetes AT nataliaskrasnovskaya ovarianreserveinreproductiveagewomenwithtype1diabetes AT robertkmikheev ovarianreserveinreproductiveagewomenwithtype1diabetes AT elenanandreeva ovarianreserveinreproductiveagewomenwithtype1diabetes AT ivanidedov ovarianreserveinreproductiveagewomenwithtype1diabetes
_version_	1718429519107325952

Ovarian reserve in reproductive age women with type 1 diabetes

Ejemplares similares