Pandemic Vibrio cholerae shuts down site-specific recombination to retain an interbacterial defence mechanism

Vibrio cholerae uses a type VI secretion system (T6SS) to kill neighbouring competitors. Here, Santoriello et al. show that a T6SS gene cluster (Aux3) exists as a mobile, prophage-like element in some environmental strains, and as a stable truncated form in pandemic isolates. They propose that Aux3...

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Autores principales:	Francis J. Santoriello, Lina Michel, Daniel Unterweger, Stefan Pukatzki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3bd7107edecd4b59a2f8bab1cbcf6c11
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spelling	oai:doaj.org-article:3bd7107edecd4b59a2f8bab1cbcf6c112021-12-02T10:47:52ZPandemic Vibrio cholerae shuts down site-specific recombination to retain an interbacterial defence mechanism10.1038/s41467-020-20012-72041-1723https://doaj.org/article/3bd7107edecd4b59a2f8bab1cbcf6c112020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20012-7https://doaj.org/toc/2041-1723Vibrio cholerae uses a type VI secretion system (T6SS) to kill neighbouring competitors. Here, Santoriello et al. show that a T6SS gene cluster (Aux3) exists as a mobile, prophage-like element in some environmental strains, and as a stable truncated form in pandemic isolates. They propose that Aux3 acquisition increased competitive fitness of pre-pandemic V. cholerae.Francis J. SantorielloLina MichelDaniel UnterwegerStefan PukatzkiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Francis J. Santoriello Lina Michel Daniel Unterweger Stefan Pukatzki Pandemic Vibrio cholerae shuts down site-specific recombination to retain an interbacterial defence mechanism
description	Vibrio cholerae uses a type VI secretion system (T6SS) to kill neighbouring competitors. Here, Santoriello et al. show that a T6SS gene cluster (Aux3) exists as a mobile, prophage-like element in some environmental strains, and as a stable truncated form in pandemic isolates. They propose that Aux3 acquisition increased competitive fitness of pre-pandemic V. cholerae.
format	article
author	Francis J. Santoriello Lina Michel Daniel Unterweger Stefan Pukatzki
author_facet	Francis J. Santoriello Lina Michel Daniel Unterweger Stefan Pukatzki
author_sort	Francis J. Santoriello
title	Pandemic Vibrio cholerae shuts down site-specific recombination to retain an interbacterial defence mechanism
title_short	Pandemic Vibrio cholerae shuts down site-specific recombination to retain an interbacterial defence mechanism
title_full	Pandemic Vibrio cholerae shuts down site-specific recombination to retain an interbacterial defence mechanism
title_fullStr	Pandemic Vibrio cholerae shuts down site-specific recombination to retain an interbacterial defence mechanism
title_full_unstemmed	Pandemic Vibrio cholerae shuts down site-specific recombination to retain an interbacterial defence mechanism
title_sort	pandemic vibrio cholerae shuts down site-specific recombination to retain an interbacterial defence mechanism
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3bd7107edecd4b59a2f8bab1cbcf6c11
work_keys_str_mv	AT francisjsantoriello pandemicvibriocholeraeshutsdownsitespecificrecombinationtoretainaninterbacterialdefencemechanism AT linamichel pandemicvibriocholeraeshutsdownsitespecificrecombinationtoretainaninterbacterialdefencemechanism AT danielunterweger pandemicvibriocholeraeshutsdownsitespecificrecombinationtoretainaninterbacterialdefencemechanism AT stefanpukatzki pandemicvibriocholeraeshutsdownsitespecificrecombinationtoretainaninterbacterialdefencemechanism
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Pandemic Vibrio cholerae shuts down site-specific recombination to retain an interbacterial defence mechanism

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