Association between lipid accumulation product and diabetic retinopathy based on a community-based survey in Chinese with type 2 diabetes

Jingyang Wu,1 Yifan Zhong,1 Song Yue,1 Peng Guan,2 Guisen Zhang,3 Lei Liu,1 Lei Chen11Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, People’s Republic of China; 2Department of Epidemiology, School of Public Health, China Medical Un...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wu J, Zhong Y, Yue S, Guan P, Zhang G, Liu L, Chen L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	diabetic retinopathy lipid accumulation product diabetes Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/3bd97e37ec1449e5ac576e912c0908aa
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3bd97e37ec1449e5ac576e912c0908aa
record_format	dspace
spelling	oai:doaj.org-article:3bd97e37ec1449e5ac576e912c0908aa2021-12-02T03:16:09ZAssociation between lipid accumulation product and diabetic retinopathy based on a community-based survey in Chinese with type 2 diabetes1178-7007https://doaj.org/article/3bd97e37ec1449e5ac576e912c0908aa2019-04-01T00:00:00Zhttps://www.dovepress.com/association-between-lipid-accumulation-product-and-diabetic-retinopath-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Jingyang Wu,1 Yifan Zhong,1 Song Yue,1 Peng Guan,2 Guisen Zhang,3 Lei Liu,1 Lei Chen11Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, People’s Republic of China; 2Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110122, People’s Republic of China; 3Department of Ophthalmology, Hohhot Chao Ju Eye Hospital, Hohhot 010000, People’s Republic of ChinaPurpose: Abnormal levels of lipid accumulation product (LAP) have been associated with risk of cardiovascular disease and diabetes. However, it is not clear whether LAP index is associated with diabetic retinopathy (DR). We investigated the association between LAP index and DR in Chinese adults with diabetes.Patients and methods: We included 427 Chinese patients with type 2 diabetes aged 18-year over who participated in a community-based cross-sectional study in Shenyang. DR was addressed on retinal photographs graded using the modified Airlie House classification. LAP was defined as (waist circumference [cm]–65) × (triglycerides [mmol/L]) in men, and (waist circumference [cm]–58) × (triglycerides [mmol/L]) in women and analyzed continuously (per SD change) and categorically (quartile 1, <30; quartile 2, 30–50; and quartile 3, >50).Results: Prevalence of DR among the study population was 17.8%. The mean level of LAP was 52.96±44.01. Compared to quartile 1 level, both quartile 2 and 3 levels were associated with DR with multivariable odds ratio (95% CI) of 0.23 (0.12–0.46) and 0.27 (0.14–0.54), respectively. These associations persisted when LAP was analyzed continuously (0.57 [0.35–0.92]).Conclusion: Higher central lipid accumulation in Chinese diabetics is related to the lower risk of DR, suggesting that LAP may be useful for identifying type 2 diabetes mellitus patients who are at risk for DR.Keywords: diabetic retinopathy, lipid accumulation product, diabetesWu JZhong YYue SGuan PZhang GLiu LChen LDove Medical Pressarticlediabetic retinopathylipid accumulation productdiabetesSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 513-518 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetic retinopathy lipid accumulation product diabetes Specialties of internal medicine RC581-951
spellingShingle	diabetic retinopathy lipid accumulation product diabetes Specialties of internal medicine RC581-951 Wu J Zhong Y Yue S Guan P Zhang G Liu L Chen L Association between lipid accumulation product and diabetic retinopathy based on a community-based survey in Chinese with type 2 diabetes
description	Jingyang Wu,1 Yifan Zhong,1 Song Yue,1 Peng Guan,2 Guisen Zhang,3 Lei Liu,1 Lei Chen11Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, People’s Republic of China; 2Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110122, People’s Republic of China; 3Department of Ophthalmology, Hohhot Chao Ju Eye Hospital, Hohhot 010000, People’s Republic of ChinaPurpose: Abnormal levels of lipid accumulation product (LAP) have been associated with risk of cardiovascular disease and diabetes. However, it is not clear whether LAP index is associated with diabetic retinopathy (DR). We investigated the association between LAP index and DR in Chinese adults with diabetes.Patients and methods: We included 427 Chinese patients with type 2 diabetes aged 18-year over who participated in a community-based cross-sectional study in Shenyang. DR was addressed on retinal photographs graded using the modified Airlie House classification. LAP was defined as (waist circumference [cm]–65) × (triglycerides [mmol/L]) in men, and (waist circumference [cm]–58) × (triglycerides [mmol/L]) in women and analyzed continuously (per SD change) and categorically (quartile 1, <30; quartile 2, 30–50; and quartile 3, >50).Results: Prevalence of DR among the study population was 17.8%. The mean level of LAP was 52.96±44.01. Compared to quartile 1 level, both quartile 2 and 3 levels were associated with DR with multivariable odds ratio (95% CI) of 0.23 (0.12–0.46) and 0.27 (0.14–0.54), respectively. These associations persisted when LAP was analyzed continuously (0.57 [0.35–0.92]).Conclusion: Higher central lipid accumulation in Chinese diabetics is related to the lower risk of DR, suggesting that LAP may be useful for identifying type 2 diabetes mellitus patients who are at risk for DR.Keywords: diabetic retinopathy, lipid accumulation product, diabetes
format	article
author	Wu J Zhong Y Yue S Guan P Zhang G Liu L Chen L
author_facet	Wu J Zhong Y Yue S Guan P Zhang G Liu L Chen L
author_sort	Wu J
title	Association between lipid accumulation product and diabetic retinopathy based on a community-based survey in Chinese with type 2 diabetes
title_short	Association between lipid accumulation product and diabetic retinopathy based on a community-based survey in Chinese with type 2 diabetes
title_full	Association between lipid accumulation product and diabetic retinopathy based on a community-based survey in Chinese with type 2 diabetes
title_fullStr	Association between lipid accumulation product and diabetic retinopathy based on a community-based survey in Chinese with type 2 diabetes
title_full_unstemmed	Association between lipid accumulation product and diabetic retinopathy based on a community-based survey in Chinese with type 2 diabetes
title_sort	association between lipid accumulation product and diabetic retinopathy based on a community-based survey in chinese with type 2 diabetes
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/3bd97e37ec1449e5ac576e912c0908aa
work_keys_str_mv	AT wuj associationbetweenlipidaccumulationproductanddiabeticretinopathybasedonacommunitybasedsurveyinchinesewithtype2diabetes AT zhongy associationbetweenlipidaccumulationproductanddiabeticretinopathybasedonacommunitybasedsurveyinchinesewithtype2diabetes AT yues associationbetweenlipidaccumulationproductanddiabeticretinopathybasedonacommunitybasedsurveyinchinesewithtype2diabetes AT guanp associationbetweenlipidaccumulationproductanddiabeticretinopathybasedonacommunitybasedsurveyinchinesewithtype2diabetes AT zhangg associationbetweenlipidaccumulationproductanddiabeticretinopathybasedonacommunitybasedsurveyinchinesewithtype2diabetes AT liul associationbetweenlipidaccumulationproductanddiabeticretinopathybasedonacommunitybasedsurveyinchinesewithtype2diabetes AT chenl associationbetweenlipidaccumulationproductanddiabeticretinopathybasedonacommunitybasedsurveyinchinesewithtype2diabetes
_version_	1718401847369138176

Association between lipid accumulation product and diabetic retinopathy based on a community-based survey in Chinese with type 2 diabetes

Ejemplares similares