Cultivation of hierarchical 3D scaffolds inside a perfusion bioreactor: scaffold design and finite-element analysis of fluid flow
Article highlights A design of experiments to generate 16 scaffold architectures and compositions, featuring both micropores and macrochannels, so as to provide an ideal environment for bone regeneration; The step-by-step fabrication process, examining the internal structures, and the simulation of...
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| Autores principales: | , , , , , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Springer
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/3be3aa50f7f744978550d59efa74e867 |
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| Sumario: | Article highlights A design of experiments to generate 16 scaffold architectures and compositions, featuring both micropores and macrochannels, so as to provide an ideal environment for bone regeneration; The step-by-step fabrication process, examining the internal structures, and the simulation of fluid flow (COMSOL) to supply adequate mechanical stimulation during bioreactor cultivation; The DNA content for the cell-seeded scaffolds over time (culture dish vs. a bioreactor), compared with a commercial scaffold featuring a similar porosity and pore size range. |
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