Cultivation of hierarchical 3D scaffolds inside a perfusion bioreactor: scaffold design and finite-element analysis of fluid flow

Article highlights A design of experiments to generate 16 scaffold architectures and compositions, featuring both micropores and macrochannels, so as to provide an ideal environment for bone regeneration; The step-by-step fabrication process, examining the internal structures, and the simulation of...

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Autores principales: Kaylie Sampson, Songmi Koo, Carter Gadola, Anastasiia Vasiukhina, Aditya Singh, Alexandra Spartano, Rachana Gollapudi, Matthew Duley, Jens Mueller, Paul F. James, Amy M. Yousefi
Formato: article
Lenguaje:EN
Publicado: Springer 2021
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Acceso en línea:https://doaj.org/article/3be3aa50f7f744978550d59efa74e867
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Sumario:Article highlights A design of experiments to generate 16 scaffold architectures and compositions, featuring both micropores and macrochannels, so as to provide an ideal environment for bone regeneration; The step-by-step fabrication process, examining the internal structures, and the simulation of fluid flow (COMSOL) to supply adequate mechanical stimulation during bioreactor cultivation; The DNA content for the cell-seeded scaffolds over time (culture dish vs. a bioreactor), compared with a commercial scaffold featuring a similar porosity and pore size range.