Cultivation of hierarchical 3D scaffolds inside a perfusion bioreactor: scaffold design and finite-element analysis of fluid flow

Article highlights A design of experiments to generate 16 scaffold architectures and compositions, featuring both micropores and macrochannels, so as to provide an ideal environment for bone regeneration; The step-by-step fabrication process, examining the internal structures, and the simulation of...

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Autores principales:	Kaylie Sampson, Songmi Koo, Carter Gadola, Anastasiia Vasiukhina, Aditya Singh, Alexandra Spartano, Rachana Gollapudi, Matthew Duley, Jens Mueller, Paul F. James, Amy M. Yousefi
Formato:	article
Lenguaje:	EN
Publicado:	Springer 2021
Materias:	Phase separation 3D-plotting COMSOL simulation Perfusion bioreactor Design of experiments Science Q Technology T
Acceso en línea:	https://doaj.org/article/3be3aa50f7f744978550d59efa74e867
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spelling	oai:doaj.org-article:3be3aa50f7f744978550d59efa74e8672021-11-28T12:13:31ZCultivation of hierarchical 3D scaffolds inside a perfusion bioreactor: scaffold design and finite-element analysis of fluid flow10.1007/s42452-021-04871-32523-39632523-3971https://doaj.org/article/3be3aa50f7f744978550d59efa74e8672021-11-01T00:00:00Zhttps://doi.org/10.1007/s42452-021-04871-3https://doaj.org/toc/2523-3963https://doaj.org/toc/2523-3971Article highlights A design of experiments to generate 16 scaffold architectures and compositions, featuring both micropores and macrochannels, so as to provide an ideal environment for bone regeneration; The step-by-step fabrication process, examining the internal structures, and the simulation of fluid flow (COMSOL) to supply adequate mechanical stimulation during bioreactor cultivation; The DNA content for the cell-seeded scaffolds over time (culture dish vs. a bioreactor), compared with a commercial scaffold featuring a similar porosity and pore size range.Kaylie SampsonSongmi KooCarter GadolaAnastasiia VasiukhinaAditya SinghAlexandra SpartanoRachana GollapudiMatthew DuleyJens MuellerPaul F. JamesAmy M. YousefiSpringerarticlePhase separation3D-plottingCOMSOL simulationPerfusion bioreactorDesign of experimentsScienceQTechnologyTENSN Applied Sciences, Vol 3, Iss 12, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Phase separation 3D-plotting COMSOL simulation Perfusion bioreactor Design of experiments Science Q Technology T
spellingShingle	Phase separation 3D-plotting COMSOL simulation Perfusion bioreactor Design of experiments Science Q Technology T Kaylie Sampson Songmi Koo Carter Gadola Anastasiia Vasiukhina Aditya Singh Alexandra Spartano Rachana Gollapudi Matthew Duley Jens Mueller Paul F. James Amy M. Yousefi Cultivation of hierarchical 3D scaffolds inside a perfusion bioreactor: scaffold design and finite-element analysis of fluid flow
description	Article highlights A design of experiments to generate 16 scaffold architectures and compositions, featuring both micropores and macrochannels, so as to provide an ideal environment for bone regeneration; The step-by-step fabrication process, examining the internal structures, and the simulation of fluid flow (COMSOL) to supply adequate mechanical stimulation during bioreactor cultivation; The DNA content for the cell-seeded scaffolds over time (culture dish vs. a bioreactor), compared with a commercial scaffold featuring a similar porosity and pore size range.
format	article
author	Kaylie Sampson Songmi Koo Carter Gadola Anastasiia Vasiukhina Aditya Singh Alexandra Spartano Rachana Gollapudi Matthew Duley Jens Mueller Paul F. James Amy M. Yousefi
author_facet	Kaylie Sampson Songmi Koo Carter Gadola Anastasiia Vasiukhina Aditya Singh Alexandra Spartano Rachana Gollapudi Matthew Duley Jens Mueller Paul F. James Amy M. Yousefi
author_sort	Kaylie Sampson
title	Cultivation of hierarchical 3D scaffolds inside a perfusion bioreactor: scaffold design and finite-element analysis of fluid flow
title_short	Cultivation of hierarchical 3D scaffolds inside a perfusion bioreactor: scaffold design and finite-element analysis of fluid flow
title_full	Cultivation of hierarchical 3D scaffolds inside a perfusion bioreactor: scaffold design and finite-element analysis of fluid flow
title_fullStr	Cultivation of hierarchical 3D scaffolds inside a perfusion bioreactor: scaffold design and finite-element analysis of fluid flow
title_full_unstemmed	Cultivation of hierarchical 3D scaffolds inside a perfusion bioreactor: scaffold design and finite-element analysis of fluid flow
title_sort	cultivation of hierarchical 3d scaffolds inside a perfusion bioreactor: scaffold design and finite-element analysis of fluid flow
publisher	Springer
publishDate	2021
url	https://doaj.org/article/3be3aa50f7f744978550d59efa74e867
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Cultivation of hierarchical 3D scaffolds inside a perfusion bioreactor: scaffold design and finite-element analysis of fluid flow

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