Time-course changes of oxidative stress response to high-intensity discontinuous training versus moderate-intensity continuous training in masters runners.

Beneficial systemic effects of regular physical exercise have been demonstrated to reduce risks of a number of age-related disorders. Antioxidant capacity adaptations are amongst these fundamental changes in response to exercise training. However, it has been claimed that acute physical exercise per...

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Autores principales:	Alessandra Vezzoli, Lorenzo Pugliese, Mauro Marzorati, Fabio Rubens Serpiello, Antonio La Torre, Simone Porcelli
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3be6fadd59bc426d93a5d0af2e91d6a2
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spelling	oai:doaj.org-article:3be6fadd59bc426d93a5d0af2e91d6a22021-11-18T08:34:32ZTime-course changes of oxidative stress response to high-intensity discontinuous training versus moderate-intensity continuous training in masters runners.1932-620310.1371/journal.pone.0087506https://doaj.org/article/3be6fadd59bc426d93a5d0af2e91d6a22014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24498121/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Beneficial systemic effects of regular physical exercise have been demonstrated to reduce risks of a number of age-related disorders. Antioxidant capacity adaptations are amongst these fundamental changes in response to exercise training. However, it has been claimed that acute physical exercise performed at high intensity (>60% of maximal oxygen uptake) may result in oxidative stress, due to reactive oxygen species being generated excessively by enhanced oxygen consumption. The aim of this study was to evaluate the effect of high-intensity discontinuous training (HIDT), characterized by repeated variations of intensity and changes of redox potential, on oxidative damage. Twenty long-distance masters runners (age 47.8 ± 7.8 yr) on the basis of the individual values of gas exchange threshold were assigned to a different 8-weeks training program: continuous moderate-intensity training (MOD, n = 10) or HIDT (n = 10). In both groups before (PRE) and after (POST) training we examined the following oxidative damage markers: thiobarbituric acid reactive substances (TBARS) as marker of lipid peroxidation; protein carbonyls (PC) as marker of protein oxidation; 8-hydroxy-2-deoxy-guanosine (8-OH-dG) as a biomarker of DNA base modifications; and total antioxidant capacity (TAC) as indicator of the overall antioxidant system. Training induced a significant (p<0.05) decrease in resting plasma TBARS concentration in both MOD (7.53 ± 0.30 and 6.46 ± 0.27 µM, PRE and POST respectively) and HIDT (7.21 ± 0.32 and 5.85 ± 0.46 µM, PRE and POST respectively). Resting urinary 8-OH-dG levels were significantly decreased in both MOD (5.50 ± 0.66 and 4.16 ± 0.40 ng mg(-1)creatinine, PRE and POST respectively) and HIDT (4.52 ± 0.50 and 3.18 ± 0.34 ng mg(-1)creatinine, PRE and POST respectively). Training both in MOD and HIDT did not significantly modify plasma levels of PC. Resting plasma TAC was reduced in MOD while no significant changes were observed in HIDT. In conclusion, these results suggest that in masters runners high-intensity discontinuous does not cause higher level of exercise-induced oxidative stress than continuous moderate-intensity training, inducing similar beneficial effects on redox homeostasis.Alessandra VezzoliLorenzo PuglieseMauro MarzoratiFabio Rubens SerpielloAntonio La TorreSimone PorcelliPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e87506 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alessandra Vezzoli Lorenzo Pugliese Mauro Marzorati Fabio Rubens Serpiello Antonio La Torre Simone Porcelli Time-course changes of oxidative stress response to high-intensity discontinuous training versus moderate-intensity continuous training in masters runners.
description	Beneficial systemic effects of regular physical exercise have been demonstrated to reduce risks of a number of age-related disorders. Antioxidant capacity adaptations are amongst these fundamental changes in response to exercise training. However, it has been claimed that acute physical exercise performed at high intensity (>60% of maximal oxygen uptake) may result in oxidative stress, due to reactive oxygen species being generated excessively by enhanced oxygen consumption. The aim of this study was to evaluate the effect of high-intensity discontinuous training (HIDT), characterized by repeated variations of intensity and changes of redox potential, on oxidative damage. Twenty long-distance masters runners (age 47.8 ± 7.8 yr) on the basis of the individual values of gas exchange threshold were assigned to a different 8-weeks training program: continuous moderate-intensity training (MOD, n = 10) or HIDT (n = 10). In both groups before (PRE) and after (POST) training we examined the following oxidative damage markers: thiobarbituric acid reactive substances (TBARS) as marker of lipid peroxidation; protein carbonyls (PC) as marker of protein oxidation; 8-hydroxy-2-deoxy-guanosine (8-OH-dG) as a biomarker of DNA base modifications; and total antioxidant capacity (TAC) as indicator of the overall antioxidant system. Training induced a significant (p<0.05) decrease in resting plasma TBARS concentration in both MOD (7.53 ± 0.30 and 6.46 ± 0.27 µM, PRE and POST respectively) and HIDT (7.21 ± 0.32 and 5.85 ± 0.46 µM, PRE and POST respectively). Resting urinary 8-OH-dG levels were significantly decreased in both MOD (5.50 ± 0.66 and 4.16 ± 0.40 ng mg(-1)creatinine, PRE and POST respectively) and HIDT (4.52 ± 0.50 and 3.18 ± 0.34 ng mg(-1)creatinine, PRE and POST respectively). Training both in MOD and HIDT did not significantly modify plasma levels of PC. Resting plasma TAC was reduced in MOD while no significant changes were observed in HIDT. In conclusion, these results suggest that in masters runners high-intensity discontinuous does not cause higher level of exercise-induced oxidative stress than continuous moderate-intensity training, inducing similar beneficial effects on redox homeostasis.
format	article
author	Alessandra Vezzoli Lorenzo Pugliese Mauro Marzorati Fabio Rubens Serpiello Antonio La Torre Simone Porcelli
author_facet	Alessandra Vezzoli Lorenzo Pugliese Mauro Marzorati Fabio Rubens Serpiello Antonio La Torre Simone Porcelli
author_sort	Alessandra Vezzoli
title	Time-course changes of oxidative stress response to high-intensity discontinuous training versus moderate-intensity continuous training in masters runners.
title_short	Time-course changes of oxidative stress response to high-intensity discontinuous training versus moderate-intensity continuous training in masters runners.
title_full	Time-course changes of oxidative stress response to high-intensity discontinuous training versus moderate-intensity continuous training in masters runners.
title_fullStr	Time-course changes of oxidative stress response to high-intensity discontinuous training versus moderate-intensity continuous training in masters runners.
title_full_unstemmed	Time-course changes of oxidative stress response to high-intensity discontinuous training versus moderate-intensity continuous training in masters runners.
title_sort	time-course changes of oxidative stress response to high-intensity discontinuous training versus moderate-intensity continuous training in masters runners.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/3be6fadd59bc426d93a5d0af2e91d6a2
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Time-course changes of oxidative stress response to high-intensity discontinuous training versus moderate-intensity continuous training in masters runners.

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