Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission

Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission

In rodent models of type 2 diabetes, sustained remission of hyperglycemia can be induced by FGF1 action in the mediobasal hypothalamus. Here, the authors show that FGF1-injection is followed by marked changes in glial cell populations and that the sustained glycemic response is dependent on intact m...

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Autores principales: Marie A. Bentsen, Dylan M. Rausch, Zaman Mirzadeh, Kenjiro Muta, Jarrad M. Scarlett, Jenny M. Brown, Vicente Herranz-Pérez, Arian F. Baquero, Jonatan Thompson, Kimberly M. Alonge, Chelsea L. Faber, Karl J. Kaiyala, Camdin Bennett, Charles Pyke, Cecilia Ratner, Kristoffer L. Egerod, Birgitte Holst, Thomas H. Meek, Burak Kutlu, Yu Zhang, Thomas Sparso, Kevin L. Grove, Gregory J. Morton, Birgitte R. Kornum, José-Manuel García-Verdugo, Anna Secher, Rasmus Jorgensen, Michael W. Schwartz, Tune H. Pers
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/3be801c6633040a49c4814f636359746
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spelling oai:doaj.org-article:3be801c6633040a49c4814f6363597462021-12-02T14:55:09ZTranscriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission10.1038/s41467-020-17720-52041-1723https://doaj.org/article/3be801c6633040a49c4814f6363597462020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17720-5https://doaj.org/toc/2041-1723In rodent models of type 2 diabetes, sustained remission of hyperglycemia can be induced by FGF1 action in the mediobasal hypothalamus. Here, the authors show that FGF1-injection is followed by marked changes in glial cell populations and that the sustained glycemic response is dependent on intact melanocortin signaling.Marie A. BentsenDylan M. RauschZaman MirzadehKenjiro MutaJarrad M. ScarlettJenny M. BrownVicente Herranz-PérezArian F. BaqueroJonatan ThompsonKimberly M. AlongeChelsea L. FaberKarl J. KaiyalaCamdin BennettCharles PykeCecilia RatnerKristoffer L. EgerodBirgitte HolstThomas H. MeekBurak KutluYu ZhangThomas SparsoKevin L. GroveGregory J. MortonBirgitte R. KornumJosé-Manuel García-VerdugoAnna SecherRasmus JorgensenMichael W. SchwartzTune H. PersNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Marie A. Bentsen
Dylan M. Rausch
Zaman Mirzadeh
Kenjiro Muta
Jarrad M. Scarlett
Jenny M. Brown
Vicente Herranz-Pérez
Arian F. Baquero
Jonatan Thompson
Kimberly M. Alonge
Chelsea L. Faber
Karl J. Kaiyala
Camdin Bennett
Charles Pyke
Cecilia Ratner
Kristoffer L. Egerod
Birgitte Holst
Thomas H. Meek
Burak Kutlu
Yu Zhang
Thomas Sparso
Kevin L. Grove
Gregory J. Morton
Birgitte R. Kornum
José-Manuel García-Verdugo
Anna Secher
Rasmus Jorgensen
Michael W. Schwartz
Tune H. Pers
Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission
description In rodent models of type 2 diabetes, sustained remission of hyperglycemia can be induced by FGF1 action in the mediobasal hypothalamus. Here, the authors show that FGF1-injection is followed by marked changes in glial cell populations and that the sustained glycemic response is dependent on intact melanocortin signaling.
format article
author Marie A. Bentsen
Dylan M. Rausch
Zaman Mirzadeh
Kenjiro Muta
Jarrad M. Scarlett
Jenny M. Brown
Vicente Herranz-Pérez
Arian F. Baquero
Jonatan Thompson
Kimberly M. Alonge
Chelsea L. Faber
Karl J. Kaiyala
Camdin Bennett
Charles Pyke
Cecilia Ratner
Kristoffer L. Egerod
Birgitte Holst
Thomas H. Meek
Burak Kutlu
Yu Zhang
Thomas Sparso
Kevin L. Grove
Gregory J. Morton
Birgitte R. Kornum
José-Manuel García-Verdugo
Anna Secher
Rasmus Jorgensen
Michael W. Schwartz
Tune H. Pers
author_facet Marie A. Bentsen
Dylan M. Rausch
Zaman Mirzadeh
Kenjiro Muta
Jarrad M. Scarlett
Jenny M. Brown
Vicente Herranz-Pérez
Arian F. Baquero
Jonatan Thompson
Kimberly M. Alonge
Chelsea L. Faber
Karl J. Kaiyala
Camdin Bennett
Charles Pyke
Cecilia Ratner
Kristoffer L. Egerod
Birgitte Holst
Thomas H. Meek
Burak Kutlu
Yu Zhang
Thomas Sparso
Kevin L. Grove
Gregory J. Morton
Birgitte R. Kornum
José-Manuel García-Verdugo
Anna Secher
Rasmus Jorgensen
Michael W. Schwartz
Tune H. Pers
author_sort Marie A. Bentsen
title Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission
title_short Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission
title_full Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission
title_fullStr Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission
title_full_unstemmed Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission
title_sort transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/3be801c6633040a49c4814f636359746
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