The CsrA-FliW network controls polar localization of the dual-function flagellin mRNA in Campylobacter jejuni

The CsrA protein binds to and represses translation of certain bacterial mRNAs. Here, Dugar et al. show for the human pathogen Campylobacter jejunithat the major flagellin mRNA acts as both a target and a regulatory 'sponge' for CsrA, and is localized at the cell poles in a translation-dep...

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Autores principales: Gaurav Dugar, Sarah L. Svensson, Thorsten Bischler, Sina Wäldchen, Richard Reinhardt, Markus Sauer, Cynthia M. Sharma
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/3be9406422e4440bb0325020fd9d1cf9
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Sumario:The CsrA protein binds to and represses translation of certain bacterial mRNAs. Here, Dugar et al. show for the human pathogen Campylobacter jejunithat the major flagellin mRNA acts as both a target and a regulatory 'sponge' for CsrA, and is localized at the cell poles in a translation-dependent manner.